A facile method for the synthesis of glaucine and norglaucine from boldine

Wei Jan Huang, Chung Hsiung Chen, Om V. Singh, Su Lin Lee, Shoei Sheng Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)


A large-scale preparation of glaucine was achieved by reacting boldine with trimethylphenylammonium chloride and potassium t-butoxide in high yield. Treatment of glaucine with 30% H202, subsequent with hydrated ferrous sulfate, afforded norglaucine in an overall yield of 40%.

Original languageEnglish
Pages (from-to)3681-3686
Number of pages6
JournalSynthetic Communications
Issue number23
Publication statusPublished - 2002
Externally publishedYes



  • Glaucine
  • Large-scale preparation
  • Norglaucine

ASJC Scopus subject areas

  • Organic Chemistry

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