A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension

Paul Chan, Brian Tomlinson, Yi Jen Chen, Ju Chi Liu, Ming Hsiung Hsieh, Juei Tang Cheng

Research output: Contribution to journalArticle

158 Citations (Scopus)

Abstract

Aims: Stevioside is a natural plant glycoside isolated from the plant Stevia rebaudiana which has been commercialized as a sweetener in Japan for more than 20 years. Previous animal studies have shown that stevioside has an antihypertensive effect. This study was to designed to evaluate the effect of stevioside in human hypertension. Methods: A multicentre, randomized, double-blind, placebo-controlled study was undertaken. This study group consisted of 106 Chinese hypertensive subjects with diastolic blood pressure between 95 and 110 mmHg and ages ranging from 28 to 75 years with 60 subjects (men 34, women 26; mean ± s.d, 54.1±3.8 years) allocated to active treatment and 46 (men 19, women 27; mean ±s.d, 53.7±4.1 years) to placebo treatment. Each subject was given capsules containing stevioside (250 mg) or placebo thrice daily and followed-up at monthly intervals for 1 year. Results: After 3 months, the systolic and diastolic blood pressure of the stevioside group decreased significantly (systolic: 166.0±9.4-152.6±6.8 mmHg; diastolic: 104.7±5.2-90.3±3.6 mmHg, P

Original languageEnglish
Pages (from-to)215-220
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Volume50
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

Placebos
Hypertension
Blood Pressure
Stevia
Sweetening Agents
Glycosides
Antihypertensive Agents
Capsules
Japan
stevioside
Therapeutics

Keywords

  • Compliance
  • Hypertension
  • Stevioside

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. / Chan, Paul; Tomlinson, Brian; Chen, Yi Jen; Liu, Ju Chi; Hsieh, Ming Hsiung; Cheng, Juei Tang.

In: British Journal of Clinical Pharmacology, Vol. 50, No. 3, 2000, p. 215-220.

Research output: Contribution to journalArticle

@article{40e9ba34b6154c048f4f7f69d81be856,
title = "A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension",
abstract = "Aims: Stevioside is a natural plant glycoside isolated from the plant Stevia rebaudiana which has been commercialized as a sweetener in Japan for more than 20 years. Previous animal studies have shown that stevioside has an antihypertensive effect. This study was to designed to evaluate the effect of stevioside in human hypertension. Methods: A multicentre, randomized, double-blind, placebo-controlled study was undertaken. This study group consisted of 106 Chinese hypertensive subjects with diastolic blood pressure between 95 and 110 mmHg and ages ranging from 28 to 75 years with 60 subjects (men 34, women 26; mean ± s.d, 54.1±3.8 years) allocated to active treatment and 46 (men 19, women 27; mean ±s.d, 53.7±4.1 years) to placebo treatment. Each subject was given capsules containing stevioside (250 mg) or placebo thrice daily and followed-up at monthly intervals for 1 year. Results: After 3 months, the systolic and diastolic blood pressure of the stevioside group decreased significantly (systolic: 166.0±9.4-152.6±6.8 mmHg; diastolic: 104.7±5.2-90.3±3.6 mmHg, P",
keywords = "Compliance, Hypertension, Stevioside",
author = "Paul Chan and Brian Tomlinson and Chen, {Yi Jen} and Liu, {Ju Chi} and Hsieh, {Ming Hsiung} and Cheng, {Juei Tang}",
year = "2000",
doi = "10.1046/j.1365-2125.2000.00260.x",
language = "English",
volume = "50",
pages = "215--220",
journal = "British Journal of Clinical Pharmacology",
issn = "0306-5251",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension

AU - Chan, Paul

AU - Tomlinson, Brian

AU - Chen, Yi Jen

AU - Liu, Ju Chi

AU - Hsieh, Ming Hsiung

AU - Cheng, Juei Tang

PY - 2000

Y1 - 2000

N2 - Aims: Stevioside is a natural plant glycoside isolated from the plant Stevia rebaudiana which has been commercialized as a sweetener in Japan for more than 20 years. Previous animal studies have shown that stevioside has an antihypertensive effect. This study was to designed to evaluate the effect of stevioside in human hypertension. Methods: A multicentre, randomized, double-blind, placebo-controlled study was undertaken. This study group consisted of 106 Chinese hypertensive subjects with diastolic blood pressure between 95 and 110 mmHg and ages ranging from 28 to 75 years with 60 subjects (men 34, women 26; mean ± s.d, 54.1±3.8 years) allocated to active treatment and 46 (men 19, women 27; mean ±s.d, 53.7±4.1 years) to placebo treatment. Each subject was given capsules containing stevioside (250 mg) or placebo thrice daily and followed-up at monthly intervals for 1 year. Results: After 3 months, the systolic and diastolic blood pressure of the stevioside group decreased significantly (systolic: 166.0±9.4-152.6±6.8 mmHg; diastolic: 104.7±5.2-90.3±3.6 mmHg, P

AB - Aims: Stevioside is a natural plant glycoside isolated from the plant Stevia rebaudiana which has been commercialized as a sweetener in Japan for more than 20 years. Previous animal studies have shown that stevioside has an antihypertensive effect. This study was to designed to evaluate the effect of stevioside in human hypertension. Methods: A multicentre, randomized, double-blind, placebo-controlled study was undertaken. This study group consisted of 106 Chinese hypertensive subjects with diastolic blood pressure between 95 and 110 mmHg and ages ranging from 28 to 75 years with 60 subjects (men 34, women 26; mean ± s.d, 54.1±3.8 years) allocated to active treatment and 46 (men 19, women 27; mean ±s.d, 53.7±4.1 years) to placebo treatment. Each subject was given capsules containing stevioside (250 mg) or placebo thrice daily and followed-up at monthly intervals for 1 year. Results: After 3 months, the systolic and diastolic blood pressure of the stevioside group decreased significantly (systolic: 166.0±9.4-152.6±6.8 mmHg; diastolic: 104.7±5.2-90.3±3.6 mmHg, P

KW - Compliance

KW - Hypertension

KW - Stevioside

UR - http://www.scopus.com/inward/record.url?scp=0033818478&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033818478&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2125.2000.00260.x

DO - 10.1046/j.1365-2125.2000.00260.x

M3 - Article

C2 - 10971305

AN - SCOPUS:0033818478

VL - 50

SP - 215

EP - 220

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

SN - 0306-5251

IS - 3

ER -