A dose-dependent pharmacokinetic study on caffeic acid in rabbits after intravenous administration

Yow Shieng Uang, Kuang Yang Hsu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The dose-dependent pharmacokinetics of caffeic acid (CA) were studied in rabbits. Three different doses (5, 10, and 25mg kg-1) were administered intravenously to six rabbits each. The concentration-time profiles for CA could be fitted by a two-compartment model for each dose. The results showed that total-body clearance and elimination rate constant from the central compartment (k10) after a 5 mg kg-1 dose were greater than those after the other two doses. Furthermore, the terminal elimination half-life (β half-life) and mean residence time (MRT) after a 5 mg kg-1 dose were less than after the other doses. The AUC value increased linearly with dose within the range of 10-25 mg kg-1. Most of the unchanged caffeic acid was excreted in the urine within 2 h. The percentage of unchanged caffeic acid excreted in the urine was 63.4, 60.0, and 55.4% after doses of 5, 10, and 25 mg kg-1, respectively, which was not significantly different. However, significant differences in the renal clearances and renal excretion rate constants were observed with a 5 mg kg-1 dose compared to the other doses. On the other hand, nonrenal clearances and nonrenal excretion rate constants showed no dose-related differences. The differences observed in total-body clearance, k10, β half-life, and MRT between a 5 mg kg-1 dose and the ether doses can be explained on the basis of the differences in renal clearance and renal excretion rate constants.

Original languageEnglish
Pages (from-to)727-736
Number of pages10
JournalBiopharmaceutics and Drug Disposition
Volume18
Issue number8
DOIs
Publication statusPublished - 1997

Fingerprint

Intravenous Administration
Pharmacokinetics
Rabbits
Half-Life
Urine
Metabolic Clearance Rate
Kidney
Ether
Area Under Curve
caffeic acid
Renal Elimination

Keywords

  • Caffeic acid
  • Renal clearance
  • Renal excretion rate constant

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

A dose-dependent pharmacokinetic study on caffeic acid in rabbits after intravenous administration. / Uang, Yow Shieng; Hsu, Kuang Yang.

In: Biopharmaceutics and Drug Disposition, Vol. 18, No. 8, 1997, p. 727-736.

Research output: Contribution to journalArticle

@article{b3fce3ea5fab4d51bc60fc38f7e3f48a,
title = "A dose-dependent pharmacokinetic study on caffeic acid in rabbits after intravenous administration",
abstract = "The dose-dependent pharmacokinetics of caffeic acid (CA) were studied in rabbits. Three different doses (5, 10, and 25mg kg-1) were administered intravenously to six rabbits each. The concentration-time profiles for CA could be fitted by a two-compartment model for each dose. The results showed that total-body clearance and elimination rate constant from the central compartment (k10) after a 5 mg kg-1 dose were greater than those after the other two doses. Furthermore, the terminal elimination half-life (β half-life) and mean residence time (MRT) after a 5 mg kg-1 dose were less than after the other doses. The AUC value increased linearly with dose within the range of 10-25 mg kg-1. Most of the unchanged caffeic acid was excreted in the urine within 2 h. The percentage of unchanged caffeic acid excreted in the urine was 63.4, 60.0, and 55.4{\%} after doses of 5, 10, and 25 mg kg-1, respectively, which was not significantly different. However, significant differences in the renal clearances and renal excretion rate constants were observed with a 5 mg kg-1 dose compared to the other doses. On the other hand, nonrenal clearances and nonrenal excretion rate constants showed no dose-related differences. The differences observed in total-body clearance, k10, β half-life, and MRT between a 5 mg kg-1 dose and the ether doses can be explained on the basis of the differences in renal clearance and renal excretion rate constants.",
keywords = "Caffeic acid, Renal clearance, Renal excretion rate constant",
author = "Uang, {Yow Shieng} and Hsu, {Kuang Yang}",
year = "1997",
doi = "10.1002/(SICI)1099-081X(199711)18:8<727::AID-BDD58>3.0.CO;2-F",
language = "English",
volume = "18",
pages = "727--736",
journal = "Biopharmaceutics and Drug Disposition",
issn = "0142-2782",
publisher = "John Wiley and Sons Ltd",
number = "8",

}

TY - JOUR

T1 - A dose-dependent pharmacokinetic study on caffeic acid in rabbits after intravenous administration

AU - Uang, Yow Shieng

AU - Hsu, Kuang Yang

PY - 1997

Y1 - 1997

N2 - The dose-dependent pharmacokinetics of caffeic acid (CA) were studied in rabbits. Three different doses (5, 10, and 25mg kg-1) were administered intravenously to six rabbits each. The concentration-time profiles for CA could be fitted by a two-compartment model for each dose. The results showed that total-body clearance and elimination rate constant from the central compartment (k10) after a 5 mg kg-1 dose were greater than those after the other two doses. Furthermore, the terminal elimination half-life (β half-life) and mean residence time (MRT) after a 5 mg kg-1 dose were less than after the other doses. The AUC value increased linearly with dose within the range of 10-25 mg kg-1. Most of the unchanged caffeic acid was excreted in the urine within 2 h. The percentage of unchanged caffeic acid excreted in the urine was 63.4, 60.0, and 55.4% after doses of 5, 10, and 25 mg kg-1, respectively, which was not significantly different. However, significant differences in the renal clearances and renal excretion rate constants were observed with a 5 mg kg-1 dose compared to the other doses. On the other hand, nonrenal clearances and nonrenal excretion rate constants showed no dose-related differences. The differences observed in total-body clearance, k10, β half-life, and MRT between a 5 mg kg-1 dose and the ether doses can be explained on the basis of the differences in renal clearance and renal excretion rate constants.

AB - The dose-dependent pharmacokinetics of caffeic acid (CA) were studied in rabbits. Three different doses (5, 10, and 25mg kg-1) were administered intravenously to six rabbits each. The concentration-time profiles for CA could be fitted by a two-compartment model for each dose. The results showed that total-body clearance and elimination rate constant from the central compartment (k10) after a 5 mg kg-1 dose were greater than those after the other two doses. Furthermore, the terminal elimination half-life (β half-life) and mean residence time (MRT) after a 5 mg kg-1 dose were less than after the other doses. The AUC value increased linearly with dose within the range of 10-25 mg kg-1. Most of the unchanged caffeic acid was excreted in the urine within 2 h. The percentage of unchanged caffeic acid excreted in the urine was 63.4, 60.0, and 55.4% after doses of 5, 10, and 25 mg kg-1, respectively, which was not significantly different. However, significant differences in the renal clearances and renal excretion rate constants were observed with a 5 mg kg-1 dose compared to the other doses. On the other hand, nonrenal clearances and nonrenal excretion rate constants showed no dose-related differences. The differences observed in total-body clearance, k10, β half-life, and MRT between a 5 mg kg-1 dose and the ether doses can be explained on the basis of the differences in renal clearance and renal excretion rate constants.

KW - Caffeic acid

KW - Renal clearance

KW - Renal excretion rate constant

UR - http://www.scopus.com/inward/record.url?scp=0030661613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030661613&partnerID=8YFLogxK

U2 - 10.1002/(SICI)1099-081X(199711)18:8<727::AID-BDD58>3.0.CO;2-F

DO - 10.1002/(SICI)1099-081X(199711)18:8<727::AID-BDD58>3.0.CO;2-F

M3 - Article

VL - 18

SP - 727

EP - 736

JO - Biopharmaceutics and Drug Disposition

JF - Biopharmaceutics and Drug Disposition

SN - 0142-2782

IS - 8

ER -