A diet containing grape powder ameliorates the cognitive decline in aged rats with a long-term high-fructose-high-fat dietary pattern

Liang Mao Chou, Ching I. Lin, Yue Hwa Chen, Hsiang Liao, Shyh Hsiang Lin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Research has suggested that the consumption of foods rich in polyphenols is beneficial to the cognitive functions of the elderly. We investigated the effects of grape consumption on spatial learning, memory performance and neurodegeneration-related protein expression in aged rats fed a high-fructose-high-fat (HFHF) diet. Six-week-old Wistar rats were fed an HFHF diet to 66 weeks of age to establish a model of an HFHF dietary pattern, before receiving intervention diets containing different amounts of grape powder for another 12 weeks in the second part of the experiment. Spatial learning, memory performance and cortical and hippocampal protein expression levels were assessed. After consuming the HFHF diet for a year, results showed that the rats fed a high grape powder-containing diet had significantly better spatial learning and memory performance, lower expression of β-amyloid and β-secretase and higher expression of α-secretase than the rats fed a low grape powder-containing diet. Therefore, long-term consumption of an HFHF diet caused a decline in cognitive functions and increased the risk factors for neurodegeneration, which could subsequently be ameliorated by the consumption of a polyphenol-rich diet.

Original languageEnglish
Pages (from-to)52-60
Number of pages9
JournalJournal of Nutritional Biochemistry
Volume34
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Dietary Fats
Vitis
Nutrition
Fructose
Powders
Rats
High Fat Diet
Diet
Amyloid Precursor Protein Secretases
Polyphenols
Fats
Cognition
Data storage equipment
Amyloid
Wistar Rats
Proteins
Cognitive Dysfunction
Food
Research
Spatial Learning

Keywords

  • Amyloid beta
  • Beta-secretase
  • Cognitive functions
  • Grape
  • Neurodegenerations
  • Polyphenols

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

A diet containing grape powder ameliorates the cognitive decline in aged rats with a long-term high-fructose-high-fat dietary pattern. / Chou, Liang Mao; Lin, Ching I.; Chen, Yue Hwa; Liao, Hsiang; Lin, Shyh Hsiang.

In: Journal of Nutritional Biochemistry, Vol. 34, 01.08.2016, p. 52-60.

Research output: Contribution to journalArticle

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