A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil

Hui‐Po ‐P Wang, On Lee, Chin‐Tsai ‐T Fan, Lain‐Tze ‐T Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A new synthesis of antihyperlipoproteinemic agent 2,2‐dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β‐lactone 6, prepared from [2+2] cycloaddition of 3‐(2,5‐dimethylphenoxy)propanal with dimethylketene. The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industrial scale of production.

Original languageEnglish
Pages (from-to)569-572
Number of pages4
JournalJournal of the Chinese Chemical Society
Volume42
Issue number3
DOIs
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Gemfibrozil
Pentanoic Acids
Hydrogenolysis
Cycloaddition
Lactones
propionaldehyde

Keywords

  • 2,2‐DimethyI‐5‐(2,5‐dimethylphenoxy)‐3‐hydroxypentanoic acid β‐lactone
  • 2,2‐Dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid
  • Dimetnylketene
  • Gemfibrozil
  • [2+2] cycloaddition

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil. / Wang, Hui‐Po ‐P; Lee, On; Fan, Chin‐Tsai ‐T; Lee, Lain‐Tze ‐T.

In: Journal of the Chinese Chemical Society, Vol. 42, No. 3, 1995, p. 569-572.

Research output: Contribution to journalArticle

Wang, Hui‐Po ‐P ; Lee, On ; Fan, Chin‐Tsai ‐T ; Lee, Lain‐Tze ‐T. / A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil. In: Journal of the Chinese Chemical Society. 1995 ; Vol. 42, No. 3. pp. 569-572.
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