A new synthesis of antihyperlipoproteinemic agent 2,2‐dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β‐lactone 6, prepared from [2+2] cycloaddition of 3‐(2,5‐dimethylphenoxy)propanal with dimethylketene. The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industrial scale of production.
- 2,2‐DimethyI‐5‐(2,5‐dimethylphenoxy)‐3‐hydroxypentanoic acid β‐lactone
- 2,2‐Dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid
- [2+2] cycloaddition
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