A Convenient Synthesis of Antihyperlipoproteinemic Agent Gemfibrozil

Hui‐Po ‐P Wang, On Lee, Chin‐Tsai ‐T Fan, Lain‐Tze ‐T Lee

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2 Citations (Scopus)

Abstract

A new synthesis of antihyperlipoproteinemic agent 2,2‐dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid (gemfibrozil, 1) is developed via hydrogenolysis of a novel β‐lactone 6, prepared from [2+2] cycloaddition of 3‐(2,5‐dimethylphenoxy)propanal with dimethylketene. The mild conditions applied in this process are especially convenient for the preparation of gemfibrozil on an industrial scale of production.

Original languageEnglish
Pages (from-to)569-572
Number of pages4
JournalJournal of the Chinese Chemical Society
Volume42
Issue number3
DOIs
Publication statusPublished - 1995
Externally publishedYes

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Keywords

  • 2,2‐DimethyI‐5‐(2,5‐dimethylphenoxy)‐3‐hydroxypentanoic acid β‐lactone
  • 2,2‐Dimethyl‐5‐(2,5‐dimethylphenoxy)pentanoic acid
  • Dimetnylketene
  • Gemfibrozil
  • [2+2] cycloaddition

ASJC Scopus subject areas

  • Chemistry(all)

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