A concise synthesis of denbinobin is described via an intramolecular free radical cyclization and Fremy's salt mediated oxidation as a key reactions. A seven-step process starting from commercially available 3,5-dimethoxybenzyl bromide (6) and 2-bromoisovanillin (5) effectively constructs the natural product denbinobin (1).

Original languageEnglish
Pages (from-to)8103-8104
Number of pages2
JournalTetrahedron Letters
Issue number47
Publication statusPublished - Nov 21 2005


  • Free radical cyclization
  • Fremy's salt oxidation
  • Natural product

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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