A concise paradigm for the construction of amide linker of 2,7-diamidoanthraquinone derivatives as potential telomerase inhibitors

Hsu Shan Huang, Jing J. Lin, Kuo Feng Huang, Cho L. Li

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A series of 2,7-bis(aminoalkanamido)anthraquinones have been synthesized by treatment of the corresponding bis(haloalkanamido) derivatives with appropriate amines. We have previously described a series of 1,4-,1,5-,1,8- and 2,6-difunctionalized anthraquinones, which exhibit different spectra of potency, together with human telomerase evaluation. A representative compounds in the series have been examined by their NMR spectroscopic study and some indications of structural identification have been discerned. The present study details the preparation of further, distinct series of symmetrical substituent on the 2,7-position regioisomeric difunctionalized amidoanthraquinone and SAR optimization will be reported in due course.

Original languageEnglish
Pages (from-to)179-187
Number of pages9
JournalTaiwan Pharmaceutical Journal
Volume59
Issue number4
Publication statusPublished - Dec 2007
Externally publishedYes

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Keywords

  • 1H-13C 2D chemical shift correlation
  • Amide linker
  • Amidoanthraquinone
  • SAR optimization
  • Telomerase inhibitors
  • Telomeric G-quadruplex structure
  • Topoisomerase II

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science

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