A comparison of the effect of carbomer-, cellulose-, and mineral oil-based artificial tear formulations

I. Jong Wang, I. C. Lin, Y. C. Hou, F. R. Hu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

PURPOSE. To compare the efficacy, safety, and local tolerance between carbomer-based artificial tears, cellulose-, and mineral oil-based artificial tears. METHODS. A randomized, open-label, parallel-group comparative 28-day study was designed for 67 patients who were randomized into three treatment groups. Measurements included the scoring of total subjective symptoms and objective signs, Schirmer-Jones test values, and tear break-up time (BUT) at baseline, and after 2 and 4 weeks of treatment. Safety of study treatment was also assessed. Outcomes measured at baseline and 2 and 4 weeks follow-up included the scoring of total subjective symptoms and objective signs, Schirmer-Jones test values, and tear BUT, subjective assessments, and safety. RESULTS. There were no differences regarding total scores, Schirmer-Jones test, or tear BUT at baseline among these three groups at 2 and 4 weeks. Patients in all three treatment groups experienced a significant improvement from baseline in total scores and Schirmer-Jones test values after treatment. Subjective assessment was better with carbomer-based treatment. CONCLUSIONS. Each artificial tear formulation successfully relieved symptoms and signs of keratoconjunctivitis sicca. The tolerance of carbomer-based artificial tears was comparable to that of cellulose- and mineral oil-based artificial tears.

Original languageEnglish
Pages (from-to)151-159
Number of pages9
JournalEuropean Journal of Ophthalmology
Volume17
Issue number2
Publication statusPublished - Mar 2007
Externally publishedYes

Keywords

  • Carbomer-based artificial tears
  • Cellulose-based artificial tears
  • Keratoconjunctivitis sicca
  • Mineral oil-based artificial tears

ASJC Scopus subject areas

  • Ophthalmology

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