A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children

Yu Lung Lau, S. J.Rupert Vessey, Ivan S.F. Chan, Tsz Leung Lee, Li Min Huang, Chin Yun Lee, Tzou-Yien Lin, Bee Wah Lee, Kow Kwan, Siti M. Kasim, Christina Y. Chan, Karen M. Kaplan, Daniel J. Distefano, Anna L. Harmon, Amy Golie, Jonathan Hartzel, Jin Xu, Shu Li, Holly Matthews, Jerald C. SadoffAlan Shaw

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

This study compared safety, tolerability, and immunogenicity of the Oka/Merck varicella vaccine and VARILRIX™ [Oka-RIT strain SmithKline Beecham Biologicals] in healthy children 12-24 months of age. Subjects were randomized in this double blind study to receive either a single dose of Oka/Merck varicella vaccine, (∼50,000 plaque forming units (PFU), Group A or ∼16,000PFU, Group B) or 1 dose of VARILRIX™, (∼40,000PFU/dose, Group C). Safety profiles in each treatment group were similar. The proportions of subjects achieving a 6-week postvaccination titer ≥5 gpELISA units in Groups A, B or C were 97.1, 95.2 and 85.6%, respectively.

Original languageEnglish
Pages (from-to)2942-2949
Number of pages8
JournalVaccine
Volume20
Issue number23-24
DOIs
Publication statusPublished - Jul 26 2002
Externally publishedYes

Keywords

  • Immunogenicity
  • Varicella vaccination
  • Varicella zoster virus

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Lau, Y. L., Vessey, S. J. R., Chan, I. S. F., Lee, T. L., Huang, L. M., Lee, C. Y., Lin, T-Y., Lee, B. W., Kwan, K., Kasim, S. M., Chan, C. Y., Kaplan, K. M., Distefano, D. J., Harmon, A. L., Golie, A., Hartzel, J., Xu, J., Li, S., Matthews, H., ... Shaw, A. (2002). A comparison of safety, tolerability and immunogenicity of Oka/Merck varicella vaccine and VARILRIX™ in healthy children. Vaccine, 20(23-24), 2942-2949. https://doi.org/10.1016/S0264-410X(02)00245-1