A comparison of Q-switched alexandrite laser and intense pulsed light for the treatment of freckles and lentigines in Asian persons

A randomized, physician-blinded, split-face comparative trial

Chia Chen Wang, Yuh Mou Sue, Chih Hsiung Yang, Chih Kang Chen

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Background: Q-switched (QS) pigmented lasers and intense pulsed light (IPL) successfully treat pigment disorders. Objective: We sought to compare efficacy and side effects of QS alexandrite laser (QSAL) and IPL for freckle and lentigo treatment in Asians. Methods: In all, 15 patients with freckles and 17 patients with lentigines were treated randomly with one session QSAL in one cheek and two sessions IPL in the other cheek at 4-week intervals. Efficacy was determined using a new pigmentation area and severity index score. Results: All patients experienced improvement (P <.0001). Postinflammatory hyperpigmentation developed in one patient with freckles and 8 patients with lentigines after QSAL. No postinflammatory hyperpigmentation occurred after IPL. Freckles achieved greater improvement after QSAL than IPL (P = .04). In lentigines, the results after IPL were better than QSAL among those with postinflammatory hyperpigmentation after QSAL. Limitations: Limitations include a small case number and short follow-up period. Conclusion: QSAL was superior to IPL for freckle treatment. IPL should be used for lentigines in Asian persons.

Original languageEnglish
Pages (from-to)804-810
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume54
Issue number5
DOIs
Publication statusPublished - May 2006

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Lentigo
Melanosis
Solid-State Lasers
Lasers
Physicians
Light
Hyperpigmentation
Cheek
Therapeutics
Pigmentation

ASJC Scopus subject areas

  • Dermatology

Cite this

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title = "A comparison of Q-switched alexandrite laser and intense pulsed light for the treatment of freckles and lentigines in Asian persons: A randomized, physician-blinded, split-face comparative trial",
abstract = "Background: Q-switched (QS) pigmented lasers and intense pulsed light (IPL) successfully treat pigment disorders. Objective: We sought to compare efficacy and side effects of QS alexandrite laser (QSAL) and IPL for freckle and lentigo treatment in Asians. Methods: In all, 15 patients with freckles and 17 patients with lentigines were treated randomly with one session QSAL in one cheek and two sessions IPL in the other cheek at 4-week intervals. Efficacy was determined using a new pigmentation area and severity index score. Results: All patients experienced improvement (P <.0001). Postinflammatory hyperpigmentation developed in one patient with freckles and 8 patients with lentigines after QSAL. No postinflammatory hyperpigmentation occurred after IPL. Freckles achieved greater improvement after QSAL than IPL (P = .04). In lentigines, the results after IPL were better than QSAL among those with postinflammatory hyperpigmentation after QSAL. Limitations: Limitations include a small case number and short follow-up period. Conclusion: QSAL was superior to IPL for freckle treatment. IPL should be used for lentigines in Asian persons.",
author = "Wang, {Chia Chen} and Sue, {Yuh Mou} and Yang, {Chih Hsiung} and Chen, {Chih Kang}",
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N2 - Background: Q-switched (QS) pigmented lasers and intense pulsed light (IPL) successfully treat pigment disorders. Objective: We sought to compare efficacy and side effects of QS alexandrite laser (QSAL) and IPL for freckle and lentigo treatment in Asians. Methods: In all, 15 patients with freckles and 17 patients with lentigines were treated randomly with one session QSAL in one cheek and two sessions IPL in the other cheek at 4-week intervals. Efficacy was determined using a new pigmentation area and severity index score. Results: All patients experienced improvement (P <.0001). Postinflammatory hyperpigmentation developed in one patient with freckles and 8 patients with lentigines after QSAL. No postinflammatory hyperpigmentation occurred after IPL. Freckles achieved greater improvement after QSAL than IPL (P = .04). In lentigines, the results after IPL were better than QSAL among those with postinflammatory hyperpigmentation after QSAL. Limitations: Limitations include a small case number and short follow-up period. Conclusion: QSAL was superior to IPL for freckle treatment. IPL should be used for lentigines in Asian persons.

AB - Background: Q-switched (QS) pigmented lasers and intense pulsed light (IPL) successfully treat pigment disorders. Objective: We sought to compare efficacy and side effects of QS alexandrite laser (QSAL) and IPL for freckle and lentigo treatment in Asians. Methods: In all, 15 patients with freckles and 17 patients with lentigines were treated randomly with one session QSAL in one cheek and two sessions IPL in the other cheek at 4-week intervals. Efficacy was determined using a new pigmentation area and severity index score. Results: All patients experienced improvement (P <.0001). Postinflammatory hyperpigmentation developed in one patient with freckles and 8 patients with lentigines after QSAL. No postinflammatory hyperpigmentation occurred after IPL. Freckles achieved greater improvement after QSAL than IPL (P = .04). In lentigines, the results after IPL were better than QSAL among those with postinflammatory hyperpigmentation after QSAL. Limitations: Limitations include a small case number and short follow-up period. Conclusion: QSAL was superior to IPL for freckle treatment. IPL should be used for lentigines in Asian persons.

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