A comparison of prognosis between patients with hepatitis B and C virus-related hepatocellular carcinoma undergoing resection surgery

Wei Yu Kao, Chien Wei Su, Gar Yang Chau, Wing Yiu Lui, Chew Wun Wu, Jaw Ching Wu

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Abstract

Background: The impact of viral factors on the prognosis of hepatocellular carcinoma (HCC) remains controversial because of heterogeneous populations included in previous reports. This study aims to compare clinicopathologic features and prognoses between patients with hepatitis B- and hepatitis C-related HCC who underwent resection surgery. Methods: We enrolled 609 patients with positive serum hepatitis B virus (HBV) surface antigen (HBsAg) and negative serum antibody against hepatitis C virus (anti-HCV) as the B-HCC group and 206 patients with negative serum HBsAg and positive anti-HCV as the C-HCC group. The overall survival rates and cumulative recurrence rates were compared between these two groups. Results: B-HCC patients were significantly younger, predominantly male, had better liver functional reserve, but more advanced tumor stage than C-HCC patients. After a median follow-up period of 40.6 months, 427 patients had died. Furthermore, 501 patients had tumor recurrence after surgery. The postoperative overall survival rates (p = 0.640) and recurrence rates (p = 0.387) of the two groups were comparable. However, the overall survival rate was higher in the B-HCC group than in the C-HCC group in the cases of transplantable HCC (p = 0.021) and Barcelona-Clinic Liver Cancer stage A HCC (p = 0.040). Conclusions: Viral etiologies were not apparent in determining outcomes of HCC patients who underwent resection due to heterogeneous studied populations. In early-stage HCC, B-HCC patients had better outcomes than C-HCC patients did because of better liver reserve and less hepatic inflammation.

Original languageEnglish
Pages (from-to)858-867
Number of pages10
JournalWorld Journal of Surgery
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 1 2011
Externally publishedYes

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Hepatitis B virus
Hepacivirus
Hepatocellular Carcinoma
Hepatitis C Antibodies
Survival Rate
Recurrence
Liver
Serum
Surface Antigens
Liver Neoplasms
Hepatitis C
Hepatitis B Surface Antigens
Hepatitis B
Population
Neoplasms

ASJC Scopus subject areas

  • Surgery

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A comparison of prognosis between patients with hepatitis B and C virus-related hepatocellular carcinoma undergoing resection surgery. / Kao, Wei Yu; Su, Chien Wei; Chau, Gar Yang; Lui, Wing Yiu; Wu, Chew Wun; Wu, Jaw Ching.

In: World Journal of Surgery, Vol. 35, No. 4, 01.04.2011, p. 858-867.

Research output: Contribution to journalArticle

Kao, Wei Yu ; Su, Chien Wei ; Chau, Gar Yang ; Lui, Wing Yiu ; Wu, Chew Wun ; Wu, Jaw Ching. / A comparison of prognosis between patients with hepatitis B and C virus-related hepatocellular carcinoma undergoing resection surgery. In: World Journal of Surgery. 2011 ; Vol. 35, No. 4. pp. 858-867.
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