A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population: The Lipid Treatment Assessment Project 2

Raul D. Santos, David D. Waters, Lisa Tarasenko, Michael Messig, J. Wouter Jukema, Cheng Wen Chiang, Jean Ferrieres, Jo Anne M Foody

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objective: This study evaluated the success in attaining non-HDL-cholesterol (non-HDL-C) goals in the multinational L-TAP 2 study. Methods: 9955 patients ≥20 years of age with dyslipidemia on stable lipid-lowering therapy were enrolled from nine countries. Results: Success rates for non-HDL-C goals were 86% in low, 70% in moderate, and 52% in high-risk patients (63% overall). In patients with triglycerides of >200 mg/dL success rates for non-HDL-C goals were 35% vs. 69% in those with ≤200 mg/dL (p <0.0001). Among patients attaining their LDL-C goal, 18% did not attain their non-HDL-C goal. In those with coronary disease and at least two risk factors, only 34% and 30% attained respectively their non-HDL-C and LDL-C goals. Rates of failure in attaining both LDL-C and non-HDL-C goals were highest in Latin America. Conclusions: Non-HDL-C goal attainment lagged behind LDL-C goal attainment; this gap was greatest in higher-risk patients.

Original languageEnglish
Pages (from-to)150-153
Number of pages4
JournalAtherosclerosis
Volume224
Issue number1
DOIs
Publication statusPublished - Sep 2012

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LDL Cholesterol
Cholesterol
Lipids
Population
Therapeutics
Latin America
Dyslipidemias
Coronary Disease
Triglycerides
oxidized low density lipoprotein

Keywords

  • Coronary heart disease
  • LDL-cholesterol
  • Non-HDL cholesterol
  • Risk factors
  • Triglycerides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population : The Lipid Treatment Assessment Project 2. / Santos, Raul D.; Waters, David D.; Tarasenko, Lisa; Messig, Michael; Jukema, J. Wouter; Chiang, Cheng Wen; Ferrieres, Jean; Foody, Jo Anne M.

In: Atherosclerosis, Vol. 224, No. 1, 09.2012, p. 150-153.

Research output: Contribution to journalArticle

Santos, Raul D. ; Waters, David D. ; Tarasenko, Lisa ; Messig, Michael ; Jukema, J. Wouter ; Chiang, Cheng Wen ; Ferrieres, Jean ; Foody, Jo Anne M. / A comparison of non-HDL and LDL cholesterol goal attainment in a large, multinational patient population : The Lipid Treatment Assessment Project 2. In: Atherosclerosis. 2012 ; Vol. 224, No. 1. pp. 150-153.
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