A comparative MR and pathological study on fetal CNS disorders

Wan Yuo Guo, Cheng Yen Chang, Donald M.T. Ho, Tai-Tong Wong, Ming Huei Sheu, Huei Cheng Cheng, Shu Jen Chen, Jeng Hsiu Hung

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Object: We used MR after sonography to help us in prenatal counseling in 58 complicated pregnancies from 1998 to 2000. Methods: All fetal MR examinations were undertaken with a 1.5-T magnet using a body-phased-array coil and an ultrafast imaging technique, half-Fourier single-shot turbo spin-echo (HASTE). Twelve fetuses were found to have major anomalies, and in each of these cases either delivery was induced or the pregnancy was terminated. In 6 of the fetuses, with anomalies of the central nervous system, postmortem examinations were then performed after they failed to survive, and these constitute the patient sample investigated in the current study. The fetal gestational ages in these 6 cases ranged from 24 to 32 weeks. MR imaging demonstrated morphological details of the anomalies. They were: alobar holoprosencephaly in 2, middle interhemispheric fusion in 1, alobar holoprosencephaly with Dandy-Walker malformations in 1, a Dandy-Walker variant in 1 and twin-twin transfusion syndrome with hypoxic-ischemic injury to the brain in 1. Conclusions: Postmortem examinations confirmed the MR diagnoses, and these observations support us in improving our understanding of the pathogenesis of fetal CNS anomalies.

Original languageEnglish
Pages (from-to)512-518
Number of pages7
JournalChild's Nervous System
Volume17
Issue number9
DOIs
Publication statusPublished - Sep 26 2001
Externally publishedYes

Fingerprint

Holoprosencephaly
Gestational Age
Autopsy
Fetus
Dandy-Walker Syndrome
Fetofetal Transfusion
Pregnancy
Magnets
Brain Injuries
Counseling
Ultrasonography
Central Nervous System
Holoprosencephaly 2
Dandy Walker variant

Keywords

  • Central nervous system
  • Comparative study
  • Congenital anomalies
  • Fetal MR
  • Postmortem examination
  • Prenatal counseling

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Guo, W. Y., Chang, C. Y., Ho, D. M. T., Wong, T-T., Sheu, M. H., Cheng, H. C., ... Hung, J. H. (2001). A comparative MR and pathological study on fetal CNS disorders. Child's Nervous System, 17(9), 512-518. https://doi.org/10.1007/s003810100471

A comparative MR and pathological study on fetal CNS disorders. / Guo, Wan Yuo; Chang, Cheng Yen; Ho, Donald M.T.; Wong, Tai-Tong; Sheu, Ming Huei; Cheng, Huei Cheng; Chen, Shu Jen; Hung, Jeng Hsiu.

In: Child's Nervous System, Vol. 17, No. 9, 26.09.2001, p. 512-518.

Research output: Contribution to journalArticle

Guo, WY, Chang, CY, Ho, DMT, Wong, T-T, Sheu, MH, Cheng, HC, Chen, SJ & Hung, JH 2001, 'A comparative MR and pathological study on fetal CNS disorders', Child's Nervous System, vol. 17, no. 9, pp. 512-518. https://doi.org/10.1007/s003810100471
Guo, Wan Yuo ; Chang, Cheng Yen ; Ho, Donald M.T. ; Wong, Tai-Tong ; Sheu, Ming Huei ; Cheng, Huei Cheng ; Chen, Shu Jen ; Hung, Jeng Hsiu. / A comparative MR and pathological study on fetal CNS disorders. In: Child's Nervous System. 2001 ; Vol. 17, No. 9. pp. 512-518.
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