A community-based RCT for oral cancer screening with toluidine blue

W. W Y Su, A. M F Yen, S. Y H Chiu, T. H H Chen

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a total of 7975 individuals, aged 15 years or older and with high-risk oral habits, to either the toluidine-blue-screened (TBS) group or the visual screening group. Results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the TBS group than in the control group. After a five-year follow-up ascertaining oral cancer development through linkage to the National Cancer Registry, the incidence rate in the TBS group (28.0 x 10-5) was non-significantly 21% lower than that in the control group (35.4 × 10-5).

Original languageEnglish
Pages (from-to)933-937
Number of pages5
JournalJournal of Dental Research
Volume89
Issue number9
DOIs
Publication statusPublished - Sep 2010
Externally publishedYes

Keywords

  • oral cancer
  • oral premalignant and malignant lesions
  • randomized controlled trial
  • screening
  • toluidine blue

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

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