A combined therapy using stimulating auricular acupoints enhances lower-level atropine eyedrops when used for myopia control in school-aged children evaluated by a pilot randomized controlled clinical trial

Chih Kai Liang, Tin Yun Ho, Tsai Chung Li, Wen-Ming Hsu, Te Mao Li, Yu Chen Lee, Wai Jane Ho, Juei Tang Cheng, Chung Yuh Tzeng, I. Ting Liu, Shih Liang Chang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: This study was designed to compare the reduction in myopia progression in patients treated with atropine eyedrops alone with patients treated with a combined treatment of atropine and stimulation of the auricular acupoints. Methods: This study was a randomized single-blind clinical controlled trial. A total of 71 school-aged children with myopia, who fulfilled the eligibility criteria, were recruited. They were randomly assigned into three groups. These were 22 treated with the 0.25% atropine (0.25A) only, 23 treated with the 0.5% atropine (0.5A) only and 26 treated with 0.25% atropine together with stimulation of the auricular acupoints (0.25A+E). The differences in the post-treatment effects among these three groups were statistically assessed. The primary outcome parameter was myopia progression, which was defined as diopter change per year (D/Y) after cycloplegic refraction measurement. Results: The mean myopia progression of the 0.25A group was 0.38 ± 0.32 D/Y. No significant difference in mean myopia progression was found between the 0.5A (0.15 ± 0.15 D/Y) and 0.25A+E (0.21 ± 0.23 D/Y) groups. However, there was a markedly reduced myopia progression in the 0.25A+E group compared to the 0.25A group (p < 0.05). Furthermore, there was no statistical difference among these three groups in axial length elongation (ALE) of eye during this stage of the investigation. Conclusions: This study demonstrates that there was efficacy in stimulating the auricular acupoints and this enhanced the action of 0.25% atropine as a means of myopia control. The result was an effect almost equal to that of 0.5% atropine alone. There is also a need that the ALE of the eye should be further investigated over a longer period using the combined therapy.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalComplementary Therapies in Medicine
Volume16
Issue number6
DOIs
Publication statusPublished - Dec 1 2008

Fingerprint

Acupuncture Points
Ophthalmic Solutions
Myopia
Atropine
Randomized Controlled Trials
Therapeutics
Eye Axial Length
Mydriatics
Controlled Clinical Trials

Keywords

  • Atropine
  • Auricular acupoint
  • Myopia
  • Randomized controlled clinical trial

ASJC Scopus subject areas

  • Complementary and Manual Therapy
  • Complementary and alternative medicine
  • Advanced and Specialised Nursing

Cite this

A combined therapy using stimulating auricular acupoints enhances lower-level atropine eyedrops when used for myopia control in school-aged children evaluated by a pilot randomized controlled clinical trial. / Liang, Chih Kai; Ho, Tin Yun; Li, Tsai Chung; Hsu, Wen-Ming; Li, Te Mao; Lee, Yu Chen; Ho, Wai Jane; Cheng, Juei Tang; Tzeng, Chung Yuh; Liu, I. Ting; Chang, Shih Liang.

In: Complementary Therapies in Medicine, Vol. 16, No. 6, 01.12.2008, p. 305-310.

Research output: Contribution to journalArticle

Liang, Chih Kai ; Ho, Tin Yun ; Li, Tsai Chung ; Hsu, Wen-Ming ; Li, Te Mao ; Lee, Yu Chen ; Ho, Wai Jane ; Cheng, Juei Tang ; Tzeng, Chung Yuh ; Liu, I. Ting ; Chang, Shih Liang. / A combined therapy using stimulating auricular acupoints enhances lower-level atropine eyedrops when used for myopia control in school-aged children evaluated by a pilot randomized controlled clinical trial. In: Complementary Therapies in Medicine. 2008 ; Vol. 16, No. 6. pp. 305-310.
@article{d2a58de681224dcab79dd4e6f3584967,
title = "A combined therapy using stimulating auricular acupoints enhances lower-level atropine eyedrops when used for myopia control in school-aged children evaluated by a pilot randomized controlled clinical trial",
abstract = "Objective: This study was designed to compare the reduction in myopia progression in patients treated with atropine eyedrops alone with patients treated with a combined treatment of atropine and stimulation of the auricular acupoints. Methods: This study was a randomized single-blind clinical controlled trial. A total of 71 school-aged children with myopia, who fulfilled the eligibility criteria, were recruited. They were randomly assigned into three groups. These were 22 treated with the 0.25{\%} atropine (0.25A) only, 23 treated with the 0.5{\%} atropine (0.5A) only and 26 treated with 0.25{\%} atropine together with stimulation of the auricular acupoints (0.25A+E). The differences in the post-treatment effects among these three groups were statistically assessed. The primary outcome parameter was myopia progression, which was defined as diopter change per year (D/Y) after cycloplegic refraction measurement. Results: The mean myopia progression of the 0.25A group was 0.38 ± 0.32 D/Y. No significant difference in mean myopia progression was found between the 0.5A (0.15 ± 0.15 D/Y) and 0.25A+E (0.21 ± 0.23 D/Y) groups. However, there was a markedly reduced myopia progression in the 0.25A+E group compared to the 0.25A group (p < 0.05). Furthermore, there was no statistical difference among these three groups in axial length elongation (ALE) of eye during this stage of the investigation. Conclusions: This study demonstrates that there was efficacy in stimulating the auricular acupoints and this enhanced the action of 0.25{\%} atropine as a means of myopia control. The result was an effect almost equal to that of 0.5{\%} atropine alone. There is also a need that the ALE of the eye should be further investigated over a longer period using the combined therapy.",
keywords = "Atropine, Auricular acupoint, Myopia, Randomized controlled clinical trial",
author = "Liang, {Chih Kai} and Ho, {Tin Yun} and Li, {Tsai Chung} and Wen-Ming Hsu and Li, {Te Mao} and Lee, {Yu Chen} and Ho, {Wai Jane} and Cheng, {Juei Tang} and Tzeng, {Chung Yuh} and Liu, {I. Ting} and Chang, {Shih Liang}",
year = "2008",
month = "12",
day = "1",
doi = "10.1016/j.ctim.2008.04.007",
language = "English",
volume = "16",
pages = "305--310",
journal = "Complementary Therapies in Medicine",
issn = "0965-2299",
publisher = "Churchill Livingstone",
number = "6",

}

TY - JOUR

T1 - A combined therapy using stimulating auricular acupoints enhances lower-level atropine eyedrops when used for myopia control in school-aged children evaluated by a pilot randomized controlled clinical trial

AU - Liang, Chih Kai

AU - Ho, Tin Yun

AU - Li, Tsai Chung

AU - Hsu, Wen-Ming

AU - Li, Te Mao

AU - Lee, Yu Chen

AU - Ho, Wai Jane

AU - Cheng, Juei Tang

AU - Tzeng, Chung Yuh

AU - Liu, I. Ting

AU - Chang, Shih Liang

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Objective: This study was designed to compare the reduction in myopia progression in patients treated with atropine eyedrops alone with patients treated with a combined treatment of atropine and stimulation of the auricular acupoints. Methods: This study was a randomized single-blind clinical controlled trial. A total of 71 school-aged children with myopia, who fulfilled the eligibility criteria, were recruited. They were randomly assigned into three groups. These were 22 treated with the 0.25% atropine (0.25A) only, 23 treated with the 0.5% atropine (0.5A) only and 26 treated with 0.25% atropine together with stimulation of the auricular acupoints (0.25A+E). The differences in the post-treatment effects among these three groups were statistically assessed. The primary outcome parameter was myopia progression, which was defined as diopter change per year (D/Y) after cycloplegic refraction measurement. Results: The mean myopia progression of the 0.25A group was 0.38 ± 0.32 D/Y. No significant difference in mean myopia progression was found between the 0.5A (0.15 ± 0.15 D/Y) and 0.25A+E (0.21 ± 0.23 D/Y) groups. However, there was a markedly reduced myopia progression in the 0.25A+E group compared to the 0.25A group (p < 0.05). Furthermore, there was no statistical difference among these three groups in axial length elongation (ALE) of eye during this stage of the investigation. Conclusions: This study demonstrates that there was efficacy in stimulating the auricular acupoints and this enhanced the action of 0.25% atropine as a means of myopia control. The result was an effect almost equal to that of 0.5% atropine alone. There is also a need that the ALE of the eye should be further investigated over a longer period using the combined therapy.

AB - Objective: This study was designed to compare the reduction in myopia progression in patients treated with atropine eyedrops alone with patients treated with a combined treatment of atropine and stimulation of the auricular acupoints. Methods: This study was a randomized single-blind clinical controlled trial. A total of 71 school-aged children with myopia, who fulfilled the eligibility criteria, were recruited. They were randomly assigned into three groups. These were 22 treated with the 0.25% atropine (0.25A) only, 23 treated with the 0.5% atropine (0.5A) only and 26 treated with 0.25% atropine together with stimulation of the auricular acupoints (0.25A+E). The differences in the post-treatment effects among these three groups were statistically assessed. The primary outcome parameter was myopia progression, which was defined as diopter change per year (D/Y) after cycloplegic refraction measurement. Results: The mean myopia progression of the 0.25A group was 0.38 ± 0.32 D/Y. No significant difference in mean myopia progression was found between the 0.5A (0.15 ± 0.15 D/Y) and 0.25A+E (0.21 ± 0.23 D/Y) groups. However, there was a markedly reduced myopia progression in the 0.25A+E group compared to the 0.25A group (p < 0.05). Furthermore, there was no statistical difference among these three groups in axial length elongation (ALE) of eye during this stage of the investigation. Conclusions: This study demonstrates that there was efficacy in stimulating the auricular acupoints and this enhanced the action of 0.25% atropine as a means of myopia control. The result was an effect almost equal to that of 0.5% atropine alone. There is also a need that the ALE of the eye should be further investigated over a longer period using the combined therapy.

KW - Atropine

KW - Auricular acupoint

KW - Myopia

KW - Randomized controlled clinical trial

UR - http://www.scopus.com/inward/record.url?scp=56349115823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56349115823&partnerID=8YFLogxK

U2 - 10.1016/j.ctim.2008.04.007

DO - 10.1016/j.ctim.2008.04.007

M3 - Article

C2 - 19028329

AN - SCOPUS:56349115823

VL - 16

SP - 305

EP - 310

JO - Complementary Therapies in Medicine

JF - Complementary Therapies in Medicine

SN - 0965-2299

IS - 6

ER -