A cohort study to evaluate the effectiveness of laparoscopic-guided local injection of etoposide in the management of women with unruptured tubal pregnancy

Ching Hui Chen, Wen Ling Lee, Li Hsuan Chiu, Hsu Dong Sun, Wei-Min Liu, Peng Hui Wang

Research output: Contribution to journalArticle

15 Citations (Scopus)


Objective: To assess the feasibility of laparoscopic-guided local injection of etoposide or methotrexate (MTX) in the management of unruptured tubal pregnancy and compare the effectiveness of the two regimens. Design: Retrospective cohort study. Setting: Medical center. Patient(s): Thirty-one women with laparoscopically diagnosed unruptured tubal pregnancy. Intervention(s): A regimen of etoposide 50 mg via laparoscopic-guided local injection (n = 17) compared with a conventional MTX 50 mg regimen (n = 11), after 3 patients were excluded (2 refusals and 1 with salpingostomy). Main Outcome Measure(s): Serial serum β-hCG levels and the success rate in both groups. Result(s): General characteristics of the patients were similar in both groups. The overall success rate was 96.4% (27 of 28). The duration between treatment and nadir of serum β-hCG level (

Original languageEnglish
Pages (from-to)654-658
Number of pages5
JournalFertility and Sterility
Issue number3
Publication statusPublished - Sep 2011



  • β-human chorionic gonadotropin
  • conservative treatment
  • etoposide
  • laparoscopic-guided local injection
  • methotrexate

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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