烏腳病病患及盛行地區健康對照下泌尿道癌之長期世代追蹤研究

Translated title of the contribution: A Cohort Study on Lower Urinary Tract Cancers in the Endemic Area of Blackfoot Disease

Kuen Fu Liaw, Shon-Fa Horng, Li Ju Lin, Yu-Mei Hsueh, Hung-Yi Chiou, Ming-His Chiang, Chien Jen Chen

Research output: Contribution to journalArticle

Abstract

This prospective study was followed-up BFD-control cohort including 257 blackfoot disease cases and 753 age-sex-residence matched healthy controls. This study was carried out to examine the relationship between long-term exposure to ingested inorganic arsenic and lower urinary tract cancers.
This cohort had a significantly higher age-sex-standardized mortality ratio (SMR) from bladder cancer than the general population in Taiwan. Compared with the general population in Taiwan as the standard population (SMR=100), the SMR from bladder cancer was 4897 for the BFD cases.
Cox's proportional hazards regression analyses of multiple risk facters associated with bladder cancer showed a statistically significiant association between arsenic exposure and risk of lower urinary tract cancers. A significant dose-response relationship was observed between lower urinary track cancers and arsenic exposure indices including duration of residing in the BFD-endemic area, duration of consuming artesian well water, and cumulative arsenic exposure dose in ppm-years. BFD patients had a significantly increased risk of lower urinary tract cancers than non-BFD controls with age-sex-adjusted relative risk of 5.40. Patients affected with arsenic related skin lesions including hyperpigmentation, hyperkeratosis and skin cancers also had an increased lower urinary tract cancers risk showing an age-sex-adjusted relative risk of 2.61 compared with unaffected controls.
None of cigarette smoking, alcohol drinking, tea drinking, vegetable consumption frequency and occupation was significantly associated with the risk of lower urinary tract cancers.
Original languageTraditional Chinese
Pages (from-to)23-31
Number of pages9
JournalTaiwan Journal of Public Health
Volume14
Issue number1
DOIs
Publication statusPublished - 1995

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