Abstract

Jia-wei-xiao-yao-san (JWXYS) is a traditional Chinese herbal medicine that is widely used to treat neuropsychological disorders. Only a few of the hepatoprotective effects of JWXYS have been studied. The aim of this study was to investigate the hepatoprotective effects of JWXYS on dimethylnitrosamine- (DMN-) induced chronic hepatitis and hepatic fibrosis in rats and to clarify the mechanism through which JWXYS exerts these effects. After the rats were treated with DMN for 3 weeks, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were significantly elevated, whereas the albumin level decreased. Although DMN was continually administered, after the 3 doses of JWXYS were orally administered, the SGOT and SGPT levels significantly decreased and the albumin level was significantly elevated. In addition, JWXYS treatment prevented liver fibrosis induced by DMN. JWXYS exhibited superoxide-dismutase-like activity and dose-dependently inhibited DMN-induced lipid peroxidation and xanthine oxidase activity in the liver of rats. Our findings suggest that JWXYS exerts antifibrotic effects against DMN-induced chronic hepatic injury. The possible mechanism is at least partially attributable to the ability of JWXYS to inhibit reactive-oxygen-species-induced membrane lipid peroxidation.

Original languageEnglish
Article number217525
JournalScientific World Journal
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Dimethylnitrosamine
Herbal Medicine
Rats
serum
Fibrosis
Liver
lipid
hepatitis
Aspartate Aminotransferases
Alanine Transaminase
Lipid Peroxidation
Albumins
membrane
kamisyoyo san
effect
Xanthine Oxidase
Chronic Hepatitis
Membrane Lipids
Serum
Liver Cirrhosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

A Chinese herbal medicine, Jia-Wei-Xiao-Yao-San, prevents dimethylnitrosamine-induced hepatic fibrosis in rats. / Chien, Shu-Chen; Chang, Wei Chiao; Lin, Pu Hua; Chang, Wei Pin; Hsu, Shih Chung; Chang, Jung Chen; Wu, Ya Chieh; Pei, Jin Kuo; Lin, Chia Hsien.

In: Scientific World Journal, Vol. 2014, 217525, 2014.

Research output: Contribution to journalArticle

Chien, Shu-Chen ; Chang, Wei Chiao ; Lin, Pu Hua ; Chang, Wei Pin ; Hsu, Shih Chung ; Chang, Jung Chen ; Wu, Ya Chieh ; Pei, Jin Kuo ; Lin, Chia Hsien. / A Chinese herbal medicine, Jia-Wei-Xiao-Yao-San, prevents dimethylnitrosamine-induced hepatic fibrosis in rats. In: Scientific World Journal. 2014 ; Vol. 2014.
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abstract = "Jia-wei-xiao-yao-san (JWXYS) is a traditional Chinese herbal medicine that is widely used to treat neuropsychological disorders. Only a few of the hepatoprotective effects of JWXYS have been studied. The aim of this study was to investigate the hepatoprotective effects of JWXYS on dimethylnitrosamine- (DMN-) induced chronic hepatitis and hepatic fibrosis in rats and to clarify the mechanism through which JWXYS exerts these effects. After the rats were treated with DMN for 3 weeks, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were significantly elevated, whereas the albumin level decreased. Although DMN was continually administered, after the 3 doses of JWXYS were orally administered, the SGOT and SGPT levels significantly decreased and the albumin level was significantly elevated. In addition, JWXYS treatment prevented liver fibrosis induced by DMN. JWXYS exhibited superoxide-dismutase-like activity and dose-dependently inhibited DMN-induced lipid peroxidation and xanthine oxidase activity in the liver of rats. Our findings suggest that JWXYS exerts antifibrotic effects against DMN-induced chronic hepatic injury. The possible mechanism is at least partially attributable to the ability of JWXYS to inhibit reactive-oxygen-species-induced membrane lipid peroxidation.",
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AU - Lin, Pu Hua

AU - Chang, Wei Pin

AU - Hsu, Shih Chung

AU - Chang, Jung Chen

AU - Wu, Ya Chieh

AU - Pei, Jin Kuo

AU - Lin, Chia Hsien

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