A case of simultaneous multiple gastric cancers with p53 gene mutation.

S. Y. Lin, M. D. Lee, C. K. Wang, Y. J. Chen, J. G. Chang

Research output: Contribution to journalArticle

Abstract

Simultaneous multiple gastric cancers are rarely observed in clinical practice, and its association with p53 gene mutation has not been mentioned in any previous reports. We report a case of advanced gastric cancer with two primary lesions in the stomach who received total gastrectomy. Tumor and surrounding normal tissues from the surgical specimen were studied by using polymerase chain reaction-single strand conformation polymorphism analysis, restriction enzyme digestion method and direct sequencing. Point mutations of p53 gene at codon 248 (CGG-->TGG) were found in both primary tumor foci. The patient developed cancerous peritonitis eight months after the operation and expired six months later. This report suggests that p53 gene mutation can occur at an earlier stage in the tumorigenesis of gastric cancer than previously reported and it might be associated with an unusual clinical and pathological presentation.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalKaohsiung Journal of Medical Sciences
Volume10
Issue number1
Publication statusPublished - Jan 1994
Externally publishedYes

Fingerprint

p53 Genes
Stomach Neoplasms
Mutation
Restriction Mapping
Gastrectomy
Peritonitis
Point Mutation
Codon
Digestion
Neoplasms
Stomach
Carcinogenesis
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lin, S. Y., Lee, M. D., Wang, C. K., Chen, Y. J., & Chang, J. G. (1994). A case of simultaneous multiple gastric cancers with p53 gene mutation. Kaohsiung Journal of Medical Sciences, 10(1), 35-39.

A case of simultaneous multiple gastric cancers with p53 gene mutation. / Lin, S. Y.; Lee, M. D.; Wang, C. K.; Chen, Y. J.; Chang, J. G.

In: Kaohsiung Journal of Medical Sciences, Vol. 10, No. 1, 01.1994, p. 35-39.

Research output: Contribution to journalArticle

Lin, SY, Lee, MD, Wang, CK, Chen, YJ & Chang, JG 1994, 'A case of simultaneous multiple gastric cancers with p53 gene mutation.', Kaohsiung Journal of Medical Sciences, vol. 10, no. 1, pp. 35-39.
Lin, S. Y. ; Lee, M. D. ; Wang, C. K. ; Chen, Y. J. ; Chang, J. G. / A case of simultaneous multiple gastric cancers with p53 gene mutation. In: Kaohsiung Journal of Medical Sciences. 1994 ; Vol. 10, No. 1. pp. 35-39.
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