A case-control study on the association between bladder cancer and prior bladder calculus

Shiu Dong Chung, Ming Chieh Tsai, Ching Chun Lin, Herng Ching Lin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Bladder calculus is associated with chronic irritation and inflammation. As there is substantial documentation that inflammation can play a direct role in carcinogenesis, to date the relationship between stone formation and bladder cancer (BC) remains unclear. This study aimed to examine the association between BC and prior bladder calculus using a population-based dataset.Methods: This case-control study included 2,086 cases who had received their first-time diagnosis of BC between 2001 and 2009 and 10,430 randomly selected controls without BC. Conditional logistic regressions were employed to explore the association between BC and having been previously diagnosed with bladder calculus.Results: Of the sampled subjects, bladder calculus was found in 71 (3.4%) cases and 105 (1.1%) controls. Conditional logistic regression analysis revealed that the odds ratio (OR) of having been diagnosed with bladder calculus before the index date for cases was 3.42 (95% CI = 2.48-4.72) when compared with controls after adjusting for monthly income, geographic region, hypertension, diabetes, coronary heart disease, and renal disease, tobacco use disorder, obesity, alcohol abuse, and schistosomiasis, bladder outlet obstruction, and urinary tract infection. We further analyzed according to sex and found that among males, the OR of having been previously diagnosed with bladder calculus for cases was 3.45 (95% CI = 2.39-4.99) that of controls. Among females, the OR was 3.05 (95% CI = 1.53-6.08) that of controls.Conclusions: These results add to the evidence surrounding the conflicting reports regarding the association between BC and prior bladder calculus and highlight a potential target population for bladder cancer screening.

Original languageEnglish
Article number117
JournalBMC Cancer
Volume13
DOIs
Publication statusPublished - Mar 15 2013

Fingerprint

Urinary Bladder Calculi
Urinary Bladder Neoplasms
Case-Control Studies
Odds Ratio
Logistic Models
Inflammation
Urinary Bladder Neck Obstruction
Tobacco Use Disorder
Health Services Needs and Demand
Schistosomiasis
Early Detection of Cancer
Urinary Tract Infections
Documentation
Alcoholism
Coronary Disease
Carcinogenesis
Obesity
Regression Analysis
Hypertension
Kidney

Keywords

  • Bladder calculus
  • Bladder cancer
  • Case-control study

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Genetics

Cite this

A case-control study on the association between bladder cancer and prior bladder calculus. / Chung, Shiu Dong; Tsai, Ming Chieh; Lin, Ching Chun; Lin, Herng Ching.

In: BMC Cancer, Vol. 13, 117, 15.03.2013.

Research output: Contribution to journalArticle

Chung, Shiu Dong ; Tsai, Ming Chieh ; Lin, Ching Chun ; Lin, Herng Ching. / A case-control study on the association between bladder cancer and prior bladder calculus. In: BMC Cancer. 2013 ; Vol. 13.
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abstract = "Background: Bladder calculus is associated with chronic irritation and inflammation. As there is substantial documentation that inflammation can play a direct role in carcinogenesis, to date the relationship between stone formation and bladder cancer (BC) remains unclear. This study aimed to examine the association between BC and prior bladder calculus using a population-based dataset.Methods: This case-control study included 2,086 cases who had received their first-time diagnosis of BC between 2001 and 2009 and 10,430 randomly selected controls without BC. Conditional logistic regressions were employed to explore the association between BC and having been previously diagnosed with bladder calculus.Results: Of the sampled subjects, bladder calculus was found in 71 (3.4{\%}) cases and 105 (1.1{\%}) controls. Conditional logistic regression analysis revealed that the odds ratio (OR) of having been diagnosed with bladder calculus before the index date for cases was 3.42 (95{\%} CI = 2.48-4.72) when compared with controls after adjusting for monthly income, geographic region, hypertension, diabetes, coronary heart disease, and renal disease, tobacco use disorder, obesity, alcohol abuse, and schistosomiasis, bladder outlet obstruction, and urinary tract infection. We further analyzed according to sex and found that among males, the OR of having been previously diagnosed with bladder calculus for cases was 3.45 (95{\%} CI = 2.39-4.99) that of controls. Among females, the OR was 3.05 (95{\%} CI = 1.53-6.08) that of controls.Conclusions: These results add to the evidence surrounding the conflicting reports regarding the association between BC and prior bladder calculus and highlight a potential target population for bladder cancer screening.",
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