A case-control study of the association of diet and obesity with gout in Taiwan

Li Ching Lyu, Chi Yin Hsu, Ching Ying Yeh, Meei Shyuan Lee, Su Hua Huang, Ching Lan Chen

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Background: Gout has been a significant metabolic disorder for Chinese men in Taiwan; however, there is insufficient information on diet and lifestyle risk factors in this population. Objective: The purpose of this case-control study was to explore potential dietary and lifestyle risk factors associated with gout in Chinese men. Design: Between 1998 and 1999, we recruited and conducted face-to-face interviews with patients from outpatient clinics in Taipei who had incident gout (n = 92) and with their healthy coworkers (controls; n = 92). Results: Systolic blood pressure, diastolic blood pressure, waist-to-hip ratio, waist-to-height ratio, and body mass index were significantly higher in cases than in controls. Family histories of gout and diabetes mellitus were strong risk factors for gout. Frequencies of vegetable and fruit consumption were significantly lower in cases than in controls. Logistic regression analyses showed that high alcohol intake and low intakes of fiber, folate, and vitamin C increased the risk of gout, but no association was found with purine intake. After covariates were controlled for, the adjusted odds ratios for the middle and highest tertiles of waist-to-height ratio (0.50-0.54 and ≥0.55, respectively) were 3.89 (95% CI: 1.32, 11.46) and 4.37 (1.18, 16.22), respectively, but no linear association was found for waist-to-hip ratio and waist circumference. Conclusions: Consumption of alcohol, but not of purine, may be a significant dietary risk factor for gout. Food sources rich in dietary fiber, folate, and vitamin C, such as fruit and vegetables, protect against gout. Waist-to-height ratio, which indicates central obesity, has a significant linear effect on gout occurrence, independent of body mass index.

Original languageEnglish
Pages (from-to)690-701
Number of pages12
JournalAmerican Journal of Clinical Nutrition
Volume78
Issue number4
Publication statusPublished - Oct 2003

Fingerprint

gout
Gout
case-control studies
Taiwan
Case-Control Studies
obesity
Obesity
Diet
diet
risk factors
Blood Pressure
waist-to-hip ratio
Waist-Hip Ratio
purines
Folic Acid
folic acid
Vegetables
Ascorbic Acid
lifestyle
body mass index

Keywords

  • Case-control study
  • Diet
  • Gout
  • Obesity
  • Taiwan
  • Waist-to-height ratio

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Lyu, L. C., Hsu, C. Y., Yeh, C. Y., Lee, M. S., Huang, S. H., & Chen, C. L. (2003). A case-control study of the association of diet and obesity with gout in Taiwan. American Journal of Clinical Nutrition, 78(4), 690-701.

A case-control study of the association of diet and obesity with gout in Taiwan. / Lyu, Li Ching; Hsu, Chi Yin; Yeh, Ching Ying; Lee, Meei Shyuan; Huang, Su Hua; Chen, Ching Lan.

In: American Journal of Clinical Nutrition, Vol. 78, No. 4, 10.2003, p. 690-701.

Research output: Contribution to journalArticle

Lyu, LC, Hsu, CY, Yeh, CY, Lee, MS, Huang, SH & Chen, CL 2003, 'A case-control study of the association of diet and obesity with gout in Taiwan', American Journal of Clinical Nutrition, vol. 78, no. 4, pp. 690-701.
Lyu LC, Hsu CY, Yeh CY, Lee MS, Huang SH, Chen CL. A case-control study of the association of diet and obesity with gout in Taiwan. American Journal of Clinical Nutrition. 2003 Oct;78(4):690-701.
Lyu, Li Ching ; Hsu, Chi Yin ; Yeh, Ching Ying ; Lee, Meei Shyuan ; Huang, Su Hua ; Chen, Ching Lan. / A case-control study of the association of diet and obesity with gout in Taiwan. In: American Journal of Clinical Nutrition. 2003 ; Vol. 78, No. 4. pp. 690-701.
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AU - Huang, Su Hua

AU - Chen, Ching Lan

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AB - Background: Gout has been a significant metabolic disorder for Chinese men in Taiwan; however, there is insufficient information on diet and lifestyle risk factors in this population. Objective: The purpose of this case-control study was to explore potential dietary and lifestyle risk factors associated with gout in Chinese men. Design: Between 1998 and 1999, we recruited and conducted face-to-face interviews with patients from outpatient clinics in Taipei who had incident gout (n = 92) and with their healthy coworkers (controls; n = 92). Results: Systolic blood pressure, diastolic blood pressure, waist-to-hip ratio, waist-to-height ratio, and body mass index were significantly higher in cases than in controls. Family histories of gout and diabetes mellitus were strong risk factors for gout. Frequencies of vegetable and fruit consumption were significantly lower in cases than in controls. Logistic regression analyses showed that high alcohol intake and low intakes of fiber, folate, and vitamin C increased the risk of gout, but no association was found with purine intake. After covariates were controlled for, the adjusted odds ratios for the middle and highest tertiles of waist-to-height ratio (0.50-0.54 and ≥0.55, respectively) were 3.89 (95% CI: 1.32, 11.46) and 4.37 (1.18, 16.22), respectively, but no linear association was found for waist-to-hip ratio and waist circumference. Conclusions: Consumption of alcohol, but not of purine, may be a significant dietary risk factor for gout. Food sources rich in dietary fiber, folate, and vitamin C, such as fruit and vegetables, protect against gout. Waist-to-height ratio, which indicates central obesity, has a significant linear effect on gout occurrence, independent of body mass index.

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