A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process

Tushar Harishchandra Punde, Wen Hao Wu, Pei Chun Lien, Po Chen Shih, Margaret Dah Tsyr Chang, Kang Yun Lee, Han Pin Kuo, Cheng Hsien Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report a 3D biomimetic microsystem which mimics lung microenvironment for monitoring the role of chemokine induced lung inflammation. The extravasation of fibrocytes in response to eosinophil cationic protein (ECP)-stimulated bronchial epithelial cells induced lung inflammation was mimicked on the micro-fluidic chip system for monitoring the microenvironmental changes.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1021-1023
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012
Externally publishedYes
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: Oct 28 2012Nov 1 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period10/28/1211/1/12

Keywords

  • Biomimetics
  • Bronchial asthma
  • Eosinophil cationic protein
  • Fibrocytes
  • Microfluidic chip

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Punde, T. H., Wu, W. H., Lien, P. C., Shih, P. C., Chang, M. D. T., Lee, K. Y., Kuo, H. P., & Liu, C. H. (2012). A bronchial epithelium-mimetic microfluidic chip system for investigating microenvironmental change-induced inflammatory process. In Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 (pp. 1021-1023). Chemical and Biological Microsystems Society.