A 10-year follow-up of triple-negative breast cancer patients in Taiwan

Che Lin, Su Yu Chien, Shou Jen Kuo, Li Sheng Chen, Shou Tung Chen, Hung Wen Lai, Tsai Wang Chang, Dar Ren Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: This study aimed to investigate whether triple-negative breast cancer has a worse prognosis; here, we present the 10-year follow-up results of triple-negative breast cancer patients in Taiwan. Methods: We identified 2858 breast cancer patients in Taiwan, of whom 416 (14.6%) had triple-negative breast cancer. Data used for analysis were derived from those breast cancer patients who were diagnosed between January 1996 and December 2006. Results: In the Kaplan-Meier analysis, tumor subgroup (triple-negative breast cancer vs. non-triple-negative breast cancer) was a prognostic factor related to 10-year breast cancer death-specific survival and disease-free survival. The results of univariate analysis showed that tumor subgroup was a significant factor related to 10-year disease-free survival and breast cancer death-specific survival, as well as menopausal status, tumor size, lymph node, metastasis, grade, stage, estrogen receptor status, progesterone receptor status and her2/neu gene expression status. Similarly, the multivariate analysis also revealed that tumor subgroup was a significant factor related to 10-year breast cancer death-specific survival and disease-free survival, in addition to tumor size, lymph node, metastasis and grade. Conclusions: It was suggested that triple-negative breast cancer patients in Taiwan have worse 10-year survival. Notably, in node-positive patients, triple-negative breast cancer played a prognostic role in 10-year breast cancer death-specific survival.

Original languageEnglish
Article numberhyr196
Pages (from-to)161-167
Number of pages7
JournalJapanese Journal of Clinical Oncology
Volume42
Issue number3
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Triple Negative Breast Neoplasms
Taiwan
Breast Neoplasms
Survival
Disease-Free Survival
Neoplasms
Lymph Nodes
Neoplasm Metastasis
erbB-2 Genes
Kaplan-Meier Estimate
Progesterone Receptors
Estrogen Receptors
Multivariate Analysis
Gene Expression

Keywords

  • Estrogen receptor
  • HER2
  • Progesterone receptor
  • Survival
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

Cite this

Lin, C., Chien, S. Y., Kuo, S. J., Chen, L. S., Chen, S. T., Lai, H. W., ... Chen, D. R. (2012). A 10-year follow-up of triple-negative breast cancer patients in Taiwan. Japanese Journal of Clinical Oncology, 42(3), 161-167. [hyr196]. https://doi.org/10.1093/jjco/hyr196

A 10-year follow-up of triple-negative breast cancer patients in Taiwan. / Lin, Che; Chien, Su Yu; Kuo, Shou Jen; Chen, Li Sheng; Chen, Shou Tung; Lai, Hung Wen; Chang, Tsai Wang; Chen, Dar Ren.

In: Japanese Journal of Clinical Oncology, Vol. 42, No. 3, hyr196, 03.2012, p. 161-167.

Research output: Contribution to journalArticle

Lin, C, Chien, SY, Kuo, SJ, Chen, LS, Chen, ST, Lai, HW, Chang, TW & Chen, DR 2012, 'A 10-year follow-up of triple-negative breast cancer patients in Taiwan', Japanese Journal of Clinical Oncology, vol. 42, no. 3, hyr196, pp. 161-167. https://doi.org/10.1093/jjco/hyr196
Lin, Che ; Chien, Su Yu ; Kuo, Shou Jen ; Chen, Li Sheng ; Chen, Shou Tung ; Lai, Hung Wen ; Chang, Tsai Wang ; Chen, Dar Ren. / A 10-year follow-up of triple-negative breast cancer patients in Taiwan. In: Japanese Journal of Clinical Oncology. 2012 ; Vol. 42, No. 3. pp. 161-167.
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