A 10-year follow-up of triple-negative breast cancer patients in Taiwan

Che Lin, Su Yu Chien, Shou Jen Kuo, Li Sheng Chen, Shou Tung Chen, Hung Wen Lai, Tsai Wang Chang, Dar Ren Chen

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7 Citations (Scopus)

Abstract

Objective: This study aimed to investigate whether triple-negative breast cancer has a worse prognosis; here, we present the 10-year follow-up results of triple-negative breast cancer patients in Taiwan. Methods: We identified 2858 breast cancer patients in Taiwan, of whom 416 (14.6%) had triple-negative breast cancer. Data used for analysis were derived from those breast cancer patients who were diagnosed between January 1996 and December 2006. Results: In the Kaplan-Meier analysis, tumor subgroup (triple-negative breast cancer vs. non-triple-negative breast cancer) was a prognostic factor related to 10-year breast cancer death-specific survival and disease-free survival. The results of univariate analysis showed that tumor subgroup was a significant factor related to 10-year disease-free survival and breast cancer death-specific survival, as well as menopausal status, tumor size, lymph node, metastasis, grade, stage, estrogen receptor status, progesterone receptor status and her2/neu gene expression status. Similarly, the multivariate analysis also revealed that tumor subgroup was a significant factor related to 10-year breast cancer death-specific survival and disease-free survival, in addition to tumor size, lymph node, metastasis and grade. Conclusions: It was suggested that triple-negative breast cancer patients in Taiwan have worse 10-year survival. Notably, in node-positive patients, triple-negative breast cancer played a prognostic role in 10-year breast cancer death-specific survival.

Original languageEnglish
Article numberhyr196
Pages (from-to)161-167
Number of pages7
JournalJapanese Journal of Clinical Oncology
Volume42
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Estrogen receptor
  • HER2
  • Progesterone receptor
  • Survival
  • Triple-negative breast cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Lin, C., Chien, S. Y., Kuo, S. J., Chen, L. S., Chen, S. T., Lai, H. W., Chang, T. W., & Chen, D. R. (2012). A 10-year follow-up of triple-negative breast cancer patients in Taiwan. Japanese Journal of Clinical Oncology, 42(3), 161-167. [hyr196]. https://doi.org/10.1093/jjco/hyr196