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• 3-Methylcholanthrene, an AhR agonist, caused cell-cycle arrest by histone deacetylation through a RhoA-dependent recruitment of HDAC1 and pRb2 to E2F1 complex

  Chang, C. C., Sue, Y. M., Yang, N. J., Lee, Y-H. & Juan, S. H., Mar 21 2014, In: PLoS One. 9, 3, e92793.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• 3-Methylcholanthrene/Aryl-Hydrocarbon Receptor-Mediated Hypertension Through eNOS Inactivation

  Chang, C-C., Hsu, Y-H., Chou, H-C., Lee, Y-C. G. & Juan, S-H., May 1 2017, In: Journal of Cellular Physiology. 232, 5, p. 1020-1029

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• 3-Nitrobenzanthrone promotes malignant transformation in human lung epithelial cells through the epiregulin-signaling pathway

  Chen, K. Y., Tseng, C. H., Feng, P. H., Sun, W. L., Ho, S. C., Lin, C. W., Van Hiep, N., Luo, C. S., Tseng, Y. H., Chen, T. T., Liu, W. T., Lee, K. Y. & Wu, S. M., 2021, (Accepted/In press) In: Cell Biology and Toxicology.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• 3-OH flavone inhibition of epidermal growth factor-induced proliferaton through blocking prostaglandin E₂ production

  Shen, S. C., Ko, C. H., Hsu, K. C. & Chen, Y. C., Feb 4 2004, In: International Journal of Cancer. 108, 4, p. 502-510 9 p.

  Research output: Contribution to journal › Article › peer-review
  35 Citations (Scopus)

• 3-O-methylquercetin more selectively inhibits phosphodiesterase subtype 3

  Ko, W. C., Chen, M. C., Wang, S. H., Lai, Y. H., Chen, J. H. & Lin, C. N., Apr 1 2003, In: Planta Medica. 69, 4, p. 310-315 6 p.

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• 3p Deletion and Small Cell Lung Carcinoma

  Whang-Peng, J., Jan 1 1989, In: Mayo Clinic Proceedings. 64, 2, p. 256-260 5 p.

  Research output: Contribution to journal › Editorial › peer-review
  7 Citations (Scopus)

• 3′UTR polymorphisms of carbonic anhydrase IX determine the miR-34a targeting efficiency and prognosis of hepatocellular carcinoma

  Hua, K. T., Liu, Y. F., Hsu, C. L., Cheng, T. Y., Yang, C. Y., Chang, J. S., Lee, W. J., Hsiao, M., Juan, H. F., Chien, M. H. & Yang, S. F., Dec 1 2017, In: Scientific Reports. 7, 1, 4466.

  Research output: Contribution to journal › Article › peer-review
  40 Citations (Scopus)

• 4,6-Diaryl/heteroarylpyrimidin-2(1H)-ones as a new class of xanthine oxidase inhibitors

  Shukla, S., Kumar, D., Ojha, R., Gupta, M. K., Nepali, K. & Bedi, P. M. S., Jan 1 2014, In: Archiv der Pharmazie. 347, 7, p. 486-495 10 p.

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• 4,6-diaryl pyrimidones as constrained chalcone analogues: Design, synthesis and evaluation as antiproliferative agents

  Kumar, D., Nepali, K., Bedi, P. M. S., Kumar, S., Malik, F. & Jain, S., Jul 1 2015, In: Anti-Cancer Agents in Medicinal Chemistry. 15, 6, p. 793-803 11 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• 4~8歲過動兒與正常兒童飲食攝取之比較

  Translated title of the contribution: Dietary intakes of 4~8 years old children with attention-deficit hyperactivity disorderYang, S-C., Chiu, W-C., Chen, J-R., Lee, J. C. & Hsieh, M-C., 1999, In: Nutritional Sciences Journal. 24, 2, p. 153-165 13 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma

  Chung, C. J., Pu, Y. S., Shiue, H. S., Lee, H. L., Lin, P., Yang, H. Y., Su, C-T. & Hsueh, Y-M., Jan 2013, In: Toxicology Letters. 216, 1, p. 16-22 7 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone is correlated with 8-hydroxy-2'-deoxyguanosine in humans after exposure to environmental tobacco smoke

  Chiang, H. C., Huang, Y. K., Chen, P. F., Chang, C. C., Wang, C. J., Lin, P. & Lee, H. L., Jan 1 2012, In: Science of the Total Environment. 414, p. 134-139 6 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• 45-60歲婦女之更年期症狀與生活品質相關因素研究

  Huang, H-M., 趙湘台(Hsiang-Tai C, 林寬佳(Kuan-Chia L, Cheng, S-Y. & Liao, Y-M., 2010, In: 新臺北護理期刊. 12, 1, p. 7-20 14 p.

  Research output: Contribution to journal › Article › peer-review

• 4-Acetylantrocamol LT3 Inhibits Glioblastoma Cell Growth and Downregulates DNA Repair Enzyme O⁶-Methylguanine-DNA Methyltransferase

  Lee, S. Y., Yen, I. C., Lin, J. C., Chung, M. C. & Liu, W. H., 2021, In: American Journal of Chinese Medicine. 49, 4, p. 983-999 17 p.

  Research output: Contribution to journal › Article › peer-review

• 4-acetyl-antroquinonol b improves the sensitization of cetuximab on both kras mutant and wild type colorectal cancer by modulating the expression of Ras/Raf/miR-193a-3p signaling axis

  Chu, Y. C., Tsai, T. Y., Yadav, V. K., Deng, L., Huang, C. C., Tzeng, Y. M., Yeh, C. T. & Chen, M. Y., Jul 2 2021, In: International journal of molecular sciences. 22, 14, 7508.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• 4-Acetylantroquinonol B induced DNA damage response signaling and apoptosis via suppressing CDK2/CDK4 expression in triple negative breast cancer cells

  Satriyo, P. B., Su, C. M., Ong, J. R., Huang, W. C., Fong, I. H., Lin, C. C., Aryandono, T., Haryana, S. M., Deng, L., Huang, C. C., Tzeng, Y. M., Chao, T. Y., Liu, H. W. & Yeh, C. T., Jul 1 2021, In: Toxicology and Applied Pharmacology. 422, 115493.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• 4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype

  Chang, T. C., Yeh, C-T., Adebayo, B. O., Lin, Y-C., Deng, L., Rao, Y. K., Huang, C. C., Lee, W. H., Wu, A. T. H., Hsiao, M., Wu, C. H., Wang, L. S. & Tzeng, Y. M., Oct 15 2015, In: Toxicology and Applied Pharmacology. 288, 2, p. 258-268 11 p.

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• 4-Acetylantroquinonol B suppresses autophagic flux and improves cisplatin sensitivity in highly aggressive epithelial cancer through the PI3K/Akt/mTOR/p70S6K signaling pathway

  Liu, M., Bamodu, O. A., Huang, W. C., Zucha, M. A., Lin, Y. K., Wu, A. T. H., Huang, C. C., Lee, W. H., Yuan, C. C., Hsiao, M., Deng, L., Tzeng, Y. M. & Yeh, C. T., Mar 15 2017, In: Toxicology and Applied Pharmacology. 325, p. 48-60 13 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• 4-acetyl-antroquinonol B suppresses SOD2-enhanced cancer stem cell-like phenotypes and chemoresistance of colorectal cancer cells by inducing hsa-miR-324 re-expression

  Bamodu, O. A., Yang, C. K., Cheng, W. H., Tzeng, D. T. W., Kuo, K. T., Huang, C. C., Deng, L., Hsiao, M., Lee, W. H. & Yeh, C. T., Aug 10 2018, In: Cancers. 10, 8, 269.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• 4- And 5-aroylindoles as novel classes of potent antitubulin agents

  Liou, J. P., Wu, C. Y., Hsieh, H. P., Chang, C. Y., Chen, C. M., Kuo, C. C. & Chang, J. Y., Sep 6 2007, In: Journal of Medicinal Chemistry. 50, 18, p. 4548-4552 5 p.

  Research output: Contribution to journal › Article › peer-review
  60 Citations (Scopus)

• 4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy

  Lin, S. Y., Yeh, T. K., Song, J. S., Hung, M. S., Cheng, M. F., Liao, F. Y., Li, A. S., Cheng, S. Y., Lin, L. M., Chiu, C. H., Wu, M. H., Lin, Y. J., Hsiao, W., Sun, M., Wang, Y. H., Huang, C. H., Tang, Y. C., Chang, H. H., Huang, Z. T., Chao, Y. S. & 5 others, Shih, C., Pan, S. L., Wu, S. Y., Kuo, C. C. & Ueng, S. H., Apr 2018, In: Bioorganic Chemistry. 77, p. 600-607 8 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• 4D spatiotemporal modulation of biomolecules distribution in anisotropic corrugated microwrinkles via electrically manipulated microcapsules within hierarchical hydrogel for spinal cord regeneration

  Chiang, M. Y., Cheng, H. W., Lo, Y. C., Wang, W. C., Chang, S. J., Cheng, C. H., Lin, Y. C., Lu, H. E., Sue, M. W., Tsou, N. T., Lo, Y. C., Li, S. J., Kuo, C. H., Chen, Y. Y., Huang, W. C. & Chen, S. Y., Apr 2021, In: Biomaterials. 271, 120762.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• 4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

  Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., Jul 7 2017, In: European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• 4-methoxy sulfonyl paeonol inhibits hepatic stellate cell activation and liver fibrosis by blocking the TGF-β1/Smad, PDGF-BB/MAPK and Akt signaling pathways

  Liao, Y. J., Wang, Y. H., Liu, C. L., Fang, C. C., Hsu, M. H. & Suk, F. M., Sep 1 2020, In: Applied Sciences (Switzerland). 10, 17, 5941.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• 4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds

  Ganzon, J. G., Chen, L. G. & Wang, C. C., 2018, In: Journal of Food and Drug Analysis.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• 4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest

  Yen, C. Y., Chiu, C. C., Chang, F. R., Chen, J. Y., Hwang, C. C., Hseu, Y. C., Yang, H. L., Lee, A. Y. L., Tsai, M. T., Guo, Z. L., Cheng, Y. S., Liu, Y. C., Lan, Y. H., Chang, Y. C., Ko, Y. C., Chang, H. W. & Wu, Y. C., Feb 18 2010, In: BMC Cancer. 10, 46.

  Research output: Contribution to journal › Article › peer-review
  80 Citations (Scopus)

• 5,5-Diphenyl-2-thiohydantoin-N10 (DPTH-N10) suppresses proliferation of cultured colon cancer cell line COLO-205 by inhibiting DNA synthesis and activating apoptosis

  Lee, T. S., Chen, L. C., Liu, Y., Wu, J., Liang, Y. C. & Lee, W. S., Jul 2010, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 382, 1, p. 43-50 8 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• 5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance

  Ruchelman, A. L., Houghton, P. J., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., Feb 10 2005, In: Journal of Medicinal Chemistry. 48, 3, p. 792-804 13 p.

  Research output: Contribution to journal › Article › peer-review
  95 Citations (Scopus)

• 500-Gray γ-Irradiation May Increase Adhesion Strength of Lyophilized Cadaveric Split-Thickness Skin Graft to Wound Bed

  Wei, L. G., Chen, C. F., Wang, C. H., Cheng, Y. C., Li, C. C., Chiu, W. K. & Wang, H-J., 2017, In: Annals of Plastic Surgery. 78, 3

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• 58-kDa microspherule protein (MSP58) is novel brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway

  Hsu, C. C., Lee, Y. C., Yeh, S. H., Chen, C. H., Wu, C. C., Wang, T. Y., Chen, Y. N., Hung, L. Y., Liu, Y. W., Chen, H. K., Hsiao, Y. T., Wang, W. S., Tsou, J. H., Tsou, Y. H., Wu, M. H., Chang, W. C. & Lin, D. Y., Jun 29 2012, In: Journal of Biological Chemistry. 287, 27, p. 22533-22548 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  30 Citations (Scopus)

• 5A/6A polymorphism of the stromelysin-1 gene and angiographic restenosis after coronary artery stenting

  Chiou, K. R., Chung, S. L. & Charng, M. J., Jan 1 2005, In: Journal of the Chinese Medical Association. 68, 11, p. 506-512 7 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• 5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase

  Ji, H-T., Chien, L-T., Lin, Y-H., Chien, H-F. & Chen, C-T., 2010, In: Molecular Cancer. 9

  Research output: Contribution to journal › Article › peer-review
  59 Citations (Scopus)

• 5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

  Nien, C. Y., Chen, Y. C., Kuo, C. C., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Liou, J. P. & Chang, J. Y., Mar 11 2010, In: Journal of Medicinal Chemistry. 53, 5, p. 2309-2313 5 p.

  Research output: Contribution to journal › Article › peer-review
  72 Citations (Scopus)

• 5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

  Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., Dec 22 2011, In: Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

  Research output: Contribution to journal › Article › peer-review
  45 Citations (Scopus)

• 5-Aminolevulinic acid induced photodynamic inactivation on Staphylococcus aureus and Pseudomonas aeruginosa

  Hsieh, C. M., Huang, Y. H., Chen, C. P., Hsieh, B. C. & Tsai, T., 2014, In: Journal of Food and Drug Analysis. 22, 3, p. 350-355 6 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• 5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

  Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Aug 23 2018, In: Journal of Medicinal Chemistry. 61, 16, p. 7087-7102 16 p.

  Research output: Contribution to journal › Article › peer-review
  37 Citations (Scopus)

• 5-Demethylnobiletin and 5-Acetoxy-6,7,8,3′,4′-pentamethoxyflavone Suppress Lipid Accumulation by Activating the LKB1-AMPK Pathway in 3T3-L1 Preadipocytes and High Fat Diet-Fed C57BL/6 Mice

  Tung, Y. C., Li, S., Huang, Q., Hung, W. L., Ho, C. T., Wei, G. J. & Pan, M. H., Apr 27 2016, In: Journal of Agricultural and Food Chemistry. 64, 16, p. 3196-3205 10 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• 5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis

  Ma, N., Lai, C. S., Chung, C. H., Yang, J. M., Hsu, K. C., Chen, C. Y., Chung, T. S., Li, S., Ho, C. T. & Pan, M. H., 2014, In: Journal of Functional Foods. 11, C, p. 528-537 10 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6] naphthyridin-6-ones and related compounds as TOP1-targeting agents: Influence of structure on the ternary cleavable complex formation

  Kerrigan, J. E., Pilch, D. S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L. & LaVoie, E. J., Oct 20 2003, In: Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3395-3399 5 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

  Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X. H., Yang, J. M., Li, T. K., Liu, A., Liu, L. F. & LaVoie, E. J., May 1 2003, In: Bioorganic and Medicinal Chemistry. 11, 9, p. 2061-2073 13 p.

  Research output: Contribution to journal › Article › peer-review
  103 Citations (Scopus)

• 5-HT modulates multiple conductances in immature rat rostral ventrolateral medulla neurones in vitro

  Hwang, L. L. & Dun, N. J., May 15 1999, In: Journal of Physiology. 517, 1, p. 217-228 12 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• 5-Hydroxytryptamine responses in immature rat rostral ventrolateral medulla neurons in vitro

  Hwang, L-L. & Dun, N. J., Sep 1998, In: Journal of Neurophysiology. 80, 3, p. 1033-1041 9 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• 5′CpG island hypermethylation and aberrant transcript splicing both contribute to the inactivation of the FHIT gene in resected non-small cell lung cancer

  Tzao, C., Tsai, H. Y., Chen, J. T., Chen, C. Y. & Wang, Y. C., Sep 2004, In: European Journal of Cancer. 40, 14, p. 2175-2183 9 p.

  Research output: Contribution to journal › Article › peer-review
  24 Citations (Scopus)

• 5-氟尿嘧啶單獨或併用遊離輻射治療人類結腸直腸癌細胞之效果

  Translated title of the contribution: Combined Treatment Effect of 5-Fluorouracil with Ionizing Radiation on Human Colorectal Carcinoma Cells黃正仲, 陳柏元, 鄧文炳, 黃家瑜, 林冠如, 吳國海, 傅秉三 & 林芳仁, 1999, In: 放射治療與腫瘤學. 6, 2, p. 73-82 10 p.

  Research output: Contribution to journal › Article › peer-review

• 5色美人餐：聰明吃，改善體質真簡單

  Yang, S-H. & 黃淑惠, Apr 2 2004, 三味文化事業有限公司. 120 p.

  Research output: Book/Report › Book

• 6,7-dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway

  Chiu, C. F., Lai, G. Y., Chen, C. H., Chiu, C. C., Hung, S. W. & Chang, C. F., Jan 1 2019, In: Drug Design, Development and Therapy. 13, p. 1609-1621 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  5 Citations (Scopus)

• ⁶⁰Co contamination in recycled steel resulting in elevated civilian radiation doses: Causes and challenges

  Chang, W. P., Chan, C. C. & Wang, J. D., Sep 1997, In: Health Physics. 73, 3, p. 465-472 8 p.

  Research output: Contribution to journal › Article › peer-review
  48 Citations (Scopus)

• 677TT polymorphism of methelenetetrahydrofolate reductase in combination with low serum vitamin B12 is associated with coronary in-stent restenosis

  Chung, S. L., Chiou, K. R. & Charng, M. J., Mar 1 2006, In: Catheterization and Cardiovascular Interventions. 67, 3, p. 349-355 7 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• 6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents

  Lin, C. M., Huang, S. T., Lee, F. W., Kuo, H-S. & Lin, M. H., Jul 1 2006, In: Bioorganic and Medicinal Chemistry. 14, 13, p. 4402-4409 8 p.

  Research output: Contribution to journal › Article › peer-review
  73 Citations (Scopus)

• 6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to trail-induced apoptosis via reactive oxygen species-mediated increase of dr5

  Chen, C. Y., Tai, C. J., Cheng, J. T., Zheng, J. J., Chen, Y. Z., Liu, T. Z., Yiin, S. J. & Chern, C. L., May 12 2010, In: Journal of Agricultural and Food Chemistry. 58, 9, p. 5604-5611 8 p.

  Research output: Contribution to journal › Article › peer-review
  24 Citations (Scopus)