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  Targeting efficiency and biodistribution of biotinylated-EGF-conjugated gelatin nanoparticles administered via aerosol delivery in nude mice with lung cancer

  Tseng, C. L., Wu, S. Y. H., Wang, W. H., Peng, C. L., Lin, F. H., Lin, C. C., Young, T. H. & Shieh, M. J., Jul 2008, In: Biomaterials. 29, 20, p. 3014-3022 9 p.

  Research output: Contribution to journal › Article › peer-review
  125 Citations (Scopus)

• Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis

  Lin, S. L., Chang, F. C., Schrimpf, C., Chen, Y. T., Wu, C. F., Wu, V. C., Chiang, W. C., Kuhnert, F., Kuo, C. J., Chen, Y. M., Wu, K. D., Tsai, T. J. & Duffield, J. S., Feb 2011, In: American Journal of Pathology. 178, 2, p. 911-923 13 p.

  Research output: Contribution to journal › Article › peer-review
  202 Citations (Scopus)

• Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator

  Lee, K. H., Hsu, E. C., Guh, J. H., Yang, H. C., Wang, D., Kulp, S. K., Shapiro, C. L. & Chen, C. S., Nov 11 2011, In: Journal of Biological Chemistry. 286, 45, p. 39247-39258 12 p.

  Research output: Contribution to journal › Article › peer-review
  85 Citations (Scopus)

• Targeting epidermal growth factor receptor in lung cancer: Perspective from the Asia-Pacific region

  Liu, H. E., Lim, K. H., Huang, M. J. & Huang, B. S., Mar 2006, In: Asia-Pacific Journal of Clinical Oncology. 2, 1, p. 22-31 10 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Targeting FAT1 inhibits carcinogenesis, induces oxidative stress and enhances cisplatin sensitivity through deregulation of LRP5/WNT2/GSS signaling axis in oral squamous cell carcinoma

  Hsu, T. N., Huang, C. M., Huang, C. S., Huang, M. S., Yeh, C. T., Chao, T. Y. & Bamodu, O. A., Dec 2019, In: Cancers. 11, 12, 1883.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  16 Citations (Scopus)

• Targeting fibrinogen-like protein 1 is a novel therapeutic strategy to combat obesity

  Wu, H. T., Chen, S. C., Fan, K. C., Kuo, C. H., Lin, S. Y., Wang, S. H., Chang, C. J. & Li, H. Y., Feb 1 2020, In: FASEB Journal. 34, 2, p. 2958-2967 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  19 Citations (Scopus)

• Targeting galectin-1 impairs castration-resistant prostate cancer progression and invasion

  Shih, T-C., Liu, R., Wu, C-T., Li, X., Xiao, W., Deng, X., Kiss, S., Wang, T., Chen, X-J., Carney, R., Kung, H-J., Duan, Y., Ghosh, P. M. & Lam, K. S., 2018, In: Clinical Cancer Research. 24, 17, p. 4319-4331 13 p.

  Research output: Contribution to journal › Article › peer-review
  24 Citations (Scopus)

• Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression

  Wu, M. H., Hong, H. C., Hong, T. M., Chiang, W. F., Jin, Y. T. & Chen, Y. L., Mar 15 2011, In: Clinical Cancer Research. 17, 6, p. 1306-1316 11 p.

  Research output: Contribution to journal › Article › peer-review
  105 Citations (Scopus)

• Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers (TNBC)

  Hong, J., Shen, Y. A., Hsu, C. Y., Huang, P., Tomaszewski, A., Gabrielson, E., Shih, I. M., Gaillard, S. & Wang, T. L., 2022, (Accepted/In press) In: Genes and Diseases. 9, 6, p. 1408-1411 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Targeting heat shock factor 1 as an antiviral strategy against dengue virus replication in vitro and in vivo

  Tsai, T. T., Chen, C. L., Tsai, C. C. & Lin, C. F., Sep 1 2017, In: Antiviral Research. 145, p. 44-53 10 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells

  Cheung, C. H. A., Chen, H. H., Cheng, L. T., Lyu, K. W., Kanwar, J. R. & Chang, J. Y., Apr 2010, In: Molecular Cancer. 9, 77.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  43 Citations (Scopus)

• Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21

  Chen, S. M., Lin, T. K., Tseng, Y. Y., Tu, C. H., Lui, T. N., Huang, S. F., Hsieh, L. L. & Li, Y. Y., Aug 2018, In: Cancer Medicine. 7, 8, p. 3988-4003 16 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer

  Wang, H. H., Wang, Y. C., Wu, D-W., Hung, C. S., Chen, C. Y. & Lee, H., Apr 1 2017, In: Tumor Biology. 39, 4

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells

  Wu, P-H., Onodera, Y., Ichikawa, Y., Rankin, E. B., Giaccia, A. J., Watanabe, Y., Qian, W., Hashimoto, T., Shirato, H. & Nam, J-M., 2017, In: International Journal of Nanomedicine. 12, p. 5069-5085 17 p.

  Research output: Contribution to journal › Article › peer-review
  73 Citations (Scopus)

• Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castrationresistant prostate cancer

  Wu, M. J., Chen, C. J., Lin, T. Y., Liu, Y. Y., Tseng, L. L., Cheng, M. L., Chuu, C. P., Tsai, H. K., Kuo, W. L., Kung, H. J. & Wang, W. C., 2021, In: Theranostics. 11, 16, p. 7779-7796 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• Targeting L1 cell adhesion molecule expression using liposomeencapsulated siRNA suppresses prostate cancer bone metastasis and growth

  Sung, S. Y., Wu, I. H., Chuang, P. H., Petros, J. A., Wu, H. C., Zeng, H. J., Huang, W. C., Chung, L. W. K. & Hsieh, C. L., 2014, In: Oncotarget. 5, 20, p. 9911-9929 19 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Targeting L1 cell adhesion molecule using lentivirus-mediated short hairpin RNA interference reverses aggressiveness of oral squamous cell carcinoma

  Hung, S. C., Wu, I. H., Hsue, S. S., Liao, C. H., Wang, H. C., Chuang, P. H., Sung, S. Y. & Hsieh, C. L., Dec 6 2010, In: Molecular Pharmaceutics. 7, 6, p. 2312-2323 12 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Targeting LncRNA HOTAIR suppresses cancer stemness and metastasis in oral carcinomas stem cells through modulation of EMT

  Lu, M. Y., Liao, Y. W., Chen, P. Y., Hsieh, P. L., Fang, C. Y., Wu, C. Y., Yen, M. L., Peng, B. Y., Wang, D. P., Cheng, H. C., Wu, C. Z., Shih, Y. H., Wang, D. J., Yu, C. C. & Tsai, L. L., Jan 1 2017, In: Oncotarget. 8, 58, p. 98542-98552 11 p.

  Research output: Contribution to journal › Article › peer-review
  57 Citations (Scopus)

• Targeting lysosomal cysteine protease cathepsin S reveals immunomodulatory therapeutic strategy for oxaliplatin-induced peripheral neuropathy

  Chen, S. J., Chen, L. H., Yeh, Y. M., Lin, C. C. K., Lin, P. C., Huang, H. W., Shen, M. R., Lin, B. W., Lee, J. C., Lee, C. C., Lee, Y. F., Chiang, H. C. & Chang, J. Y., Mar 4 2021, In: Theranostics. 11, 10, p. 4672-4687 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Targeting Mac-1-mediated leukocyte–RBC interactions uncouples the benefits for acute vaso-occlusion and chronic organ damage

  Chen, G. S., Chang, J-S., Zhang, D., Pinho, S., Jang, J. E. & Frenette, P. S., Oct 1 2016, In: Experimental Hematology. 44, 10, p. 940-946 7 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Targeting MAPK/NF-κB pathways in anti-inflammatory potential of rutaecarpine: Impact on Src/FAK-mediated macrophage migration

  Jayakumar, T., Lin, K. C., Chang, C. C., Hsia, C. H., Manubolu, M., Huang, W. C., Sheu, J. R. & Hsia, C. H., Jan 1 2022, In: International journal of molecular sciences. 23, 1, 92.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Targeting mitochondrial oxphos and their regulatory signals in prostate cancers

  Chen, C. L., Lin, C. Y. & Kung, H. J., Dec 1 2021, In: International journal of molecular sciences. 22, 24, 13435.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  5 Citations (Scopus)

• Targeting myotonic dystrophy by preimplantation genetic diagnosis-karyomapping

  Wang, C. W., Liu, Y. L. & Chen, C. H., Nov 2019, In: Taiwanese Journal of Obstetrics and Gynecology. 58, 6, p. 891-894 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Targeting nanoparticle-conjugated microbubbles combined with ultrasound-mediated microbubble destruction for enhanced tumor therapy

  Chen, K. W., Hsu, P. H., Huang, H. L., Liu, H. L., Lin, Y. T., Hsu, C. Y., Lin, J. H. & Lin, Y. H., Dec 2022, In: Pharmacological Research. 186, 106532.

  Research output: Contribution to journal › Article › peer-review

• Targeting neuropilin 1 as an antitumor strategy in lung cancer

  Hong, T. M., Chen, Y. L., Wu, Y. Y., Yuan, A., Chao, Y. C., Chung, Y. C., Wu, M. H., Yang, S. C., Pan, S. H., Shih, J. Y., Chan, W. K. & Yang, P. C., Aug 15 2007, In: Clinical Cancer Research. 13, 16, p. 4759-4768 10 p.

  Research output: Contribution to journal › Article › peer-review
  163 Citations (Scopus)

• Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer

  Su, Y-H., Tang, W. C., Cheng, Y. W., Sia, P., Huang, C. C., Lee, Y. C., Jiang, H. Y., Wu, M. H., Lai, I. L., Lee, J. W. & Lee, K. H., Oct 1 2015, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2261-2272 12 p.

  Research output: Contribution to journal › Article › peer-review
  47 Citations (Scopus)

• Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer

  Lee, Y. C., Lee, C. H., Tsai, H. P., An, H. W., Lee, C-M., Wu, J. C., Chen, C. S., Huang, S. H., Hwang, J., Cheng, K. T., Leiw, P. L., Chen, C. L. & Lin, C. M., Jul 24 2015, In: PLoS ONE. 10, 7, e0132579.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Targeting PML-RARα and oncogenic signaling pathways by Chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells

  Lai, T-I., Yao, C. J., Yang, C. M., Chuang, S. E., Yan, J. L., Liu, C. Y., Chen, S. W., Yan, K. H. & Lai, G. M., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 984154.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia

  Chang, J. F., Yeh, J. C., Ho, C. T., Liu, S. H., Hsieh, C. Y., Wang, T. M., Chang, S. W., Lee, I. T., Huang, K. Y., Wang, J. Y. & Lin, W. N., Sep 6 2019, In: International Journal of Molecular Sciences. 20, 18, 4393.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Citations (Scopus)

• Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma

  Hu, M. H., Chen, L. J., Chen, Y. L., Tsai, M. S., Shiau, C. W., Chao, T. I., Liu, C. Y., Kao, J. H. & Chen, K. F., 2017, In: Oncotarget. 8, 39, p. 65077-65089 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  14 Citations (Scopus)

• Targeting spleen tyrosine kinase-bruton's tyrosine kinase axis for immunologically mediated glomerulonephritis

  Chen, J. S., Chang, L. C., Huang, S. J. & Cheng, C. W., 2014, In: BioMed Research International. 2014, 814869.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Targeting Src-Hic-5 Signal Cascade for Preventing Migration of Cholangiocarcinoma Cell HuCCT1

  Wu, W. S., Ling, C. H., Lee, M. C., Cheng, C. C., Chen, R. F., Lin, C. F., You, R. I. & Chen, Y. C., May 2022, In: Biomedicines. 10, 5, 1022.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Targeting the CXCR4/CXCL12 axis in treating epithelial ovarian cancer

  Mao, T. L., Fan, K. F. & Liu, C. L., Oct 1 2017, In: Gene Therapy. 24, 10, p. 621-629 9 p.

  Research output: Contribution to journal › Article › peer-review
  38 Citations (Scopus)

• Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters

  Lin, Y. S., Tungpradit, R., Sinchaikul, S., An, F. M., Liu, D. Z., Phutrakul, S. & Chen, S. T., Dec 11 2008, In: Journal of Medicinal Chemistry. 51, 23, p. 7428-7441 14 p.

  Research output: Contribution to journal › Article › peer-review
  87 Citations (Scopus)

• Targeting the Epigenetic Non-Coding RNA MALAT1/Wnt Signaling Axis as a Therapeutic Approach to Suppress Stemness and Metastasis in Hepatocellular Carcinoma

  Chang, H. L., Bamodu, O. A., Ong, J. R., Lee, W. H., Yeh, C. T. & Tsai, J. T., Apr 20 2020, In: Cells. 9, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access
  20 Citations (Scopus)

• Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer

  Tseng, L. L., Cheng, H. H., Yeh, T. S., Huang, S. C., Syu, Y. Y., Chuu, C. P., Yuh, C. H., Kung, H. J. & Wang, W. C., Oct 6 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 40, p. 24859-24866 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b

  Huang, T. C., Chang, H. Y., Hsu, C. H., Kuo, W. H., Chang, K. J. & Juan, H. F., Apr 2008, In: Journal of Proteome Research. 7, 4, p. 1433-1444 12 p.

  Research output: Contribution to journal › Article › peer-review
  91 Citations (Scopus)

• Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis

  Chien, M. H., Lin, Y. W., Wen, Y. C., Yang, Y. C., Hsiao, M., Chang, J. L., Huang, H. C. & Lee, W. J., Jun 10 2019, In: Journal of Experimental and Clinical Cancer Research. 38, 1, p. 246 246.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  38 Citations (Scopus)

• Targeting the SREBP-1/Hsa-Mir-497/SCAP/FASN Oncometabolic Axis Inhibits the Cancer Stem-Like and Chemoresistant Phenotype of Non-Small Cell Lung Carcinoma Cells

  Tiong, T. Y., Weng, P. W., Wang, C. H., Setiawan, S. A., Yadav, V. K., Pikatan, N. W., Fong, I. H., Yeh, C. T., Hsu, C. H. & Kuo, K. T., Jul 1 2022, In: International journal of molecular sciences. 23, 13, 7283.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies

  Lin, Y-F., Lai, T. C., Chang, C. K., Chen, C. L., Huang, M. S., Yang, C. J., Liu, H. G., Dong, J. J., Chou, Y. A., Teng, K. H., Chen, S. H., Tian, W. T., Jan, Y. H., Hsiao, M. & Liang, P. H., Sep 3 2013, In: Journal of Clinical Investigation. 123, 9, p. 3861-3875 15 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Targeting to overexpressed glucose-regulated protein 78 in gastric cancer discovered by 2D DIGE improves the diagnostic and therapeutic efficacy of micelles-mediated system

  Cheng, C. C., Lu, N., Peng, C. L., Chang, C. C., Mai, F. D., Chen, L. Y., Liao, M. H., Wang, W. M. & Chang, J., Aug 2012, In: Proteomics. 12, 15-16, p. 2584-2597 14 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer

  Chien, C-W., Hou, P-C., Wu, H-C., Chang, Y-L., Lin, S-C., Lin, S-C., Lin, B-W., Lee, J-C., Chang, Y-J., Sun, H. S. & Tsai, S-J., Nov 10 2016, In: Oncogene. 35, 45, p. 5872-5881 10 p.

  Research output: Contribution to journal › Article › peer-review
  48 Citations (Scopus)

• Targeting Tyrosine Kinases and Autophagy in Prostate Cancer

  Kung, H. J., Feb 1 2011, In: Hormones and Cancer. 2, 1, p. 38-46 9 p.

  Research output: Contribution to journal › Article › peer-review
  38 Citations (Scopus)

• Targeting β-tubulin: CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca²⁺ entry, mitochondrial perturbation and caspase overactivation

  Lin, Y-F., Lee, Y. F. & Liang, P. H., Nov 2012, In: Cell Death and Disease. 3, 11, e434.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Tartrate-Resistant Acid Phosphatase 5a Activity as a Novel Biomarker for Flare of Systemic Lupus Erythematosus

  Chen, J. H., Wu, Y. Y., Huang, T. C., Lu, C. C., Liu, F. C., Janckila, A. J. & Chao, T-Y., Feb 2017, In: Academia Journal of Biotechnology. 5, 2, 6 p.

  Research output: Contribution to journal › Article › peer-review

• Tartrate-resistant acid phosphatase 5a in sarcoidosis: Further evidence for a novel macrophage biomarker in chronic inflammation

  Wu, Y. Y., Janckila, A. J., Slone, S. P., Perng, W. C. & Chao, T. Y., 2014, In: Journal of the Formosan Medical Association = Taiwan yi zhi. 113, 6, p. 364-370 7 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Tartrate-resistant acid phosphatase 5b activity is a useful bone marker for monitoring bone metastases in breast cancer patients after treatment

  Chung, Y. C., Ku, C. H., Chao, T. Y., Yu, J. C., Chen, M. M. & Lee, S. H., Mar 2006, In: Cancer Epidemiology Biomarkers and Prevention. 15, 3, p. 424-428 5 p.

  Research output: Contribution to journal › Article › peer-review
  35 Citations (Scopus)

• Tartrate-resistant acid phosphatase 5b as a serum marker of bone metastasis in breast cancer patients

  Chao, T. Y., Ho, C. L., Lee, S. H., Chen, M. M. J., Janckila, A. & Yam, L. T., 2004, In: Journal of Biomedical Science. 11, 4, p. 511-516 6 p.

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)

• Tartrate-resistant acid phosphatase 5b is a useful serum marker for extensive bone metastasis in breast cancer patients

  Chao, T. Y., Yu, J. C., Ku, C. H., Chen, M. M., Lee, S. H., Janckila, A. J. & Yam, L. T., Jan 15 2005, In: Clinical Cancer Research. 11, 2 I, p. 544-550 7 p.

  Research output: Contribution to journal › Article › peer-review
  52 Citations (Scopus)

• Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex

  Zhang, Z., Zhang, H., Xie, C. M., Zhang, M., Shi, Y., Song, R., Lu, X., Zhang, H., Li, K., Wang, B., Yang, Y., Li, X., Zhu, J., Zhao, Y., Yuan, T. F. & Northoff, G., Jan 2021, In: Science China Life Sciences. 64, 1, p. 96-106 11 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)