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• Downregulation of tumor suppressor MBP-1 by microRNA-363 in gastric carcinogenesis

  Hsu, K. W., Wang, A. M., Ping, Y. H., Huang, K. H., Huang, T. T., Lee, H. C., Lo, S. S., Chi, C. W. & Tsai, T-S., Jan 2014, In: Carcinogenesis. 35, 1, p. 208-217 10 p.

  Research output: Contribution to journal › Article › peer-review
  43 Citations (Scopus)

• Down-regulation of the prostate specific antigen promoter by p53 in human prostate cancer cells

  Tsui, K. H., Chang, P. L., Lin, H. T. & Juang, H. H., Nov 2004, In: Journal of Urology. 172, 5 I, p. 2035-2039 5 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Down-Regulation of the Oncogene PTTG1 via the KLF6 Tumor Suppressor during Induction of Myeloid Differentiation

  Chen, P. Y., Yen, J. H., Kao, R. H. & Chen, J. H., Aug 16 2013, In: PLoS One. 8, 8, e71282.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Downregulation of the integrin α_v signaling pathway in uterine leiomyomas

  Tsai, F-C., Liu, W-M., Pai, M-H., Hsieh, M-S., Lin, J. Y. & Chou, C-M., Mar 2011, In: Gynecologic and Obstetric Investigation. 71, 2, p. 129-135 7 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Downregulation of testosterone production through luteinizing hormone receptor regulation in male rats exposed to 17α-ethynylestradiol

  Lin, P. H., Kuo, T. H., Chen, C. C., Jian, C. Y., Chen, C. W., Wang, K. L., Kuo, Y. C., Shen, H. Y., Hsia, S. M., Wang, P. S., Lieu, F. K. & Wang, S. W., Jan 31 2020, In: Scientific Reports. 10, 1, p. 1576 1576.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Citations (Scopus)

• Down-regulation of superoxide dismutase gene expression in cultured rat aortic smooth muscle cells (A7r5) after long-term incubation with vitamin C

  Liu, J. C., Chow, J. M., Tsai, M. F., Hsieh, M. H., Chen, Y. J. & Chan, P., 2000, In: Acta Cardiologica Sinica. 16, 4, p. 209-216 8 p.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Downregulation of superoxide dismutase activity and gene expression in cultured rat brain astrocytes after incubation with vitamin C

  Kao, P. F., Lee, W. S., Liu, J. C., Chan, P., Tsai, J. C., Hsu, Y. H., Chang, W. Y., Cheng, T-H. & Liao, S. S., 2003, In: Pharmacology. 69, 1, p. 1-6 6 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Downregulation of SUN2, a novel tumor suppressor, mediates miR-221/222-induced malignancy in central nervous system embryonal tumors

  Hsieh, T. H., Chien, C. L., Lee, Y. H., Lin, C. I., Hsieh, J. Y., Chao, M. E., Liu, D. J., Chu, S. S., Chen, W., Lin, S. C., Ho, D. M. T., Liu, R. S., Lin, C. H., Wong, T-T. & Wang, H. W., Jan 1 2014, In: Carcinogenesis. 35, 10, p. 2164-2174 11 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Downregulation of STK4 promotes colon cancer invasion/migration through blocking β-catenin degradation

  Lin, C. H., Hsu, T. I., Chiou, P. Y., Hsiao, M., Wang, W. C., Chen, Y. C., Lin, J. T., Wang, J. Y., Lin, P. C., Lin, F. C., Tseng, Y. K., Cheng, H. C., Chen, C. L. & Lu, P. J., Oct 1 2020, In: Molecular Oncology. 14, 10, p. 2574-2588 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Downregulation of Sirt1 as aging change in advanced heart failure

  Lu, T. M., Tsai, J. Y., Chen, Y. C., Huang, C. Y., Hsu, H. L., Weng, C. F., Shih, C. C. & Hsu, C. P., Jun 9 2014, In: Journal of Biomedical Science. 21, 1, 57.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  74 Citations (Scopus)

• Downregulation of signaling-active IGF-1 by dipeptidyl peptidase IV (DPP-IV)

  Lin, C. T., Tang, H. Y., Han, Y. S., Liu, H. P., Huang, S. F., Chien, C. H., Shyy, J., Chiu, J. J. & Chen, X., Dec 1 2010, In: International Journal of Biomedical Science. 6, 4, p. 301-309 9 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Downregulation of PU.1 leads to decreased expression of Dectin-1 in alveolar macrophages during Pneumocystis pneumonia

  Zhang, C., Wang, S-H., Liao, C-P., Shao, S., Lasbury, M. E., Durant, P. J. & Lee, C-H., Mar 2010, In: Infection and Immunity. 78, 3, p. 1058-65 8 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Downregulation of progesterone biosynthesis in rat granulosa cells by adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) bran extracts

  Hsia, S. M., Chiang, W., Kuo, Y. H. & Wang, P. S., May 2006, In: International Journal of Impotence Research. 18, 3, p. 264-274 11 p.

  Research output: Contribution to journal › Article › peer-review
  24 Citations (Scopus)

• Downregulation of phospholipase C δ3 by cAMP and calcium

  Lin, F. G., Cheng, H. F., Lee, I. F., Kao, H. J., Loh, S. H. & Lee, W. H., 2001, In: Biochemical and Biophysical Research Communications. 286, 2, p. 274-280 7 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• Down-regulation of Notch-1 expression decreases PU.1-mediated myeloid differentiation signaling in acute myeloid leukemia

  Chen, P. M., Yen, C. C., Wang, W. S., Lin, Y. J., Chu, C. J., Chiou, T. J., Liu, J. H. & Yang, M. H., Jun 2008, In: International Journal of Oncology. 32, 6, p. 1335-1341 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  28 Citations (Scopus)

• Down-regulation of miR-29c promotes the progression of oral submucous fibrosis through targeting tropomyosin-1

  Yang, P. Y., Ho, D. C. Y., Chen, S. H., Hsieh, P. L., Liao, Y. W., Tsai, L. L., Yu, C. C. & Fang, C. Y., Jun 2022, In: Journal of the Formosan Medical Association.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells

  Yu, P. N., Yan, M. D., Lai, H-C., Huang, R. L., Chou, Y. C., Lin, W. C., Yeh, L. T. & Lin, Y. W., 2013, In: International Journal of Cancer. 134, 3, p. 542-551 10 p.

  Research output: Contribution to journal › Article › peer-review
  97 Citations (Scopus)

• Downregulation of miR-137 and miR-6500-3p promotes cell proliferation in pediatric high-grade gliomas

  Liang, M. L., Hsieh, T. H., Ng, K. H., Tsai, Y. N., Tsai, C. F., Chao, M. E., Liu, D. J., Chu, S. S., Chen, W., Liu, Y. R., Liu, R. S., Lin, S. C., Ho, D. M. T., Wong, T. T., Yang, M. H. & Wang, H. W., Apr 12 2016, In: Oncotarget. 7, 15, p. 19723-19737 15 p.

  Research output: Contribution to journal › Article › peer-review
  56 Citations (Scopus)

• Down-regulation of membrane glycoprotein in amoeboid microglia transforming into ramified microglia in postnatal rat brain

  Wu, C. H., Wen, C. Y., Shieh, J. Y. & Ling, E. A., Apr 1994, In: Journal of Neurocytology. 23, 4, p. 258-269 12 p.

  Research output: Contribution to journal › Article › peer-review
  32 Citations (Scopus)

• Down-regulation of matriptase by overexpression of bikunin attenuates cell invasion in prostate carcinoma cells

  Tsui, K. H., Chang, P. L., Feng, T. H., Chung, L. C., Hsu, S. Y. & Juang, H. H., Jul 2008, In: Anticancer Research. 28, 4 A, p. 1977-1983 7 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Down-regulation of Manganese Superoxide Dismutase Gene Expression by Vitamin C in Cultured Pheochromocytoma Cells

  Hsu, Y-H., Liu, J-C. & Chan, P., 2000, In: New Taipei Journal of Medicine. 2, 4, p. 245-250 6 p.

  Research output: Contribution to journal › Article › peer-review

• Down-regulation of L-type calcium channel and sarcoplasmic reticular Ca²⁺-ATPase mRNA in human atrial fibrillation without significant change in the mRNA of ryanodine receptor, calsequestrin and phospholamban: An insight into the mechanism of atrial electrical remodeling

  Lai, L. P., Su, M. J., Lin, J. L., Lin, F. Y., Tsai, C. H., Chen, Y. S., Huang, S. K. S., Tseng, Y. Z. & Lien, W. P., Apr 1 1999, In: Journal of the American College of Cardiology. 33, 5, p. 1231-1237 7 p.

  Research output: Contribution to journal › Article › peer-review
  179 Citations (Scopus)

• Down-regulation of let-7a-5p predicts lymph node metastasis and prognosis in colorectal cancer: Implications for chemotherapy

  Liu, T. P., Huang, C. C., Yeh, K. T., Ke, T. W., Wei, P. L., Yang, J. R. & Cheng, Y. W., Dec 1 2016, In: Surgical Oncology. 25, 4, p. 429-434

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Downregulation of histone deacetylase 8 (HDAC8) alleviated the progression of oral submucous fibrosis

  Yang, H. W., Sun, Y. H., Fang, C. Y., Ohiro, Y., Liao, H. Y., Liao, Y. W., Kao, Y. H. & Yu, C. C., 2022, (Accepted/In press) In: Journal of Dental Sciences.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Down-regulation of growth arrest DNA damage-inducible gene 45β expression is associated with human hepatocellular carcinoma

  Qiu, W., David, D., Zhou, B., Chu, P. G., Zhang, B., Wu, M., Xiao, J., Han, T., Zhu, Z., Wang, T., Liu, X., Lopez, R., Frankel, P., Jong, A. & Yen, Y., Jun 1 2003, In: American Journal of Pathology. 162, 6, p. 1961-1974 14 p.

  Research output: Contribution to journal › Article › peer-review
  67 Citations (Scopus)

• Down-regulation of gp130 in nasopharyngeal carcinoma

  Lin, Y-S., Lin, L. C., Huang, M. H., Huang, A. J. & Huang, Y. T., Jan 2009, In: American Journal of Rhinology and Allergy. 23, 1, p. 28-32 5 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Downregulation of gap junctional intercellular communication and connexin 43 expression by bisphenol A in human granulosa cells

  Lin, T. C., Wang, K. H., Chuang, K. H., Kao, A. P. & Kuo, T. C., Jun 2021, In: Biotechnology and Applied Biochemistry. 68, 3, p. 676-682 7 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Down-regulation of fatty acid synthase is associated with decreased Akt activation in lovastatin induced apoptosis cells

  Chang, Y. C., Huang, Y. H., Shih, C. M., Wu, J. Y., Liu, C. L., Wang, S. H. & Lin, C. M., Dec 2006, In: Journal of Food and Drug Analysis. 14, 4, p. 340-345 6 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Down-regulation of epidermal growth factor-induced 12-lipoxygenase expression by glucocorticoids in human epidermoid carcinoma A431 cells

  Chang, W. C., Kao, H. C. & Liu, Y. W., Sep 28 1995, In: Biochemical Pharmacology. 50, 7, p. 947-952 6 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Down-regulation of Endogenous Antioxidant Enzymes Gene Expression by Supplement of Vitamin C in Cultured Pheochromocytoma Cells

  Yang, H. Y., Cheng, J. J., Cheng, T-H., Liu, J. C., Chan, P. & Cheng, J. T., Sep 2003, In: Acta Cardiologica Sinica. 19, 3, p. 143-148 6 p.

  Research output: Contribution to journal › Article › peer-review

• Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia

  Cheng, Y. C., Lin, H., Huang, M. J., Chow, J-M., Lin, S. & Liu, H-E., Oct 2007, In: Leukemia Research. 31, 10, p. 1403-1411 9 p.

  Research output: Contribution to journal › Article › peer-review
  48 Citations (Scopus)

• Downregulation of c-Myc determines sensitivity to 2-methoxyestradiol-induced apoptosis in human acute myeloid leukemia

  Chow, J-M., Liu, C. R., Lin, C. P., Lee, C. N., Cheng, Y. C., Lin, S. & Liu, H-E., Feb 2008, In: Experimental Hematology. 36, 2, p. 140-148 9 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Downregulation of Ches1 and other novel genes in oral cancer cells chronically exposed to areca nut extract

  Chen, Y. J., Liao, C. T., Chen, P. J., Lee, L. Y., Li, Y. C., Chen, I. H., Wang, H. M., Chang, J. T., Chen, L. J., Yen, T. C., Tang, C. Y. & Cheng, A. J., Feb 2011, In: Head and Neck. 33, 2, p. 257-266 10 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Down-regulation of CD25 expression on the surface of activated tumor- infiltrating lymphocytes in human cervical carcinoma

  Sheu, B. C., Lin, R. H., Ho, H. N. & Huang, S. C., Aug 1 1997, In: Human Immunology. 56, 1-2, p. 39-48 10 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)

• Downregulation of caveolin-1 in a murine model of acute allergic airway disease

  Chen, C. M., Wu, M. Y., Chou, H. C., Lang, Y. D. & Wang, L-F., Feb 2011, In: Pediatrics and Neonatology. 52, 1, p. 5-10 6 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Downregulation of Cancer Stemness by Novel Diterpenoid Ovatodiolide Inhibits Hepatic Cancer Stem Cell-Like Traits by Repressing Wnt/β-Catenin Signaling

  Liu, M., Bamodu, O. A., Kuo, K. T., Lee, W. H., Lin, Y. K., Wu, A. T. H., M, H., Tzeng, Y. M., Yeh, C. T. & Tsai, J. T., 2018, In: American Journal of Chinese Medicine. 46, 4, p. 891-910 20 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Down regulation of bcl-2 by p53 in nasopharyngeal carcinoma and lack of detection of its specific t(14;18) chromosomal translocation in fixed tissues

  Harn, H. J., Ho, L. I., Liu, C. A., Liu, G. C., Lin, F. G., Lin, J. J., Chang, J. Y. & Lee, W. H., 1996, In: Histopathology. 28, 4, p. 317-323 7 p.

  Research output: Contribution to journal › Article › peer-review
  43 Citations (Scopus)

• Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

  Tsai, C. H., Lee, Y., Li, C. H., Cheng, Y. W. & Kang, J. J., Jun 1 2020, In: Cell Biology and Toxicology. 36, 3, p. 223-242 10 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis

  Huang, C. R., Lee, C. T., Chang, K. Y., Chang, W. C., Liu, Y. W., Lee, J. C. & Chen, B. K., 2015, In: Oncotarget. 6, 13, p. 11530-11546 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  30 Citations (Scopus)

• Down-Regulation of Apoptosis After Left Ventricular Aneurysm Repair

  Hsu, C. P., Huang, C-Y., Wang, J. S., Chiang, H. I. & Shih, C. C., Oct 2007, In: Annals of Thoracic Surgery. 84, 4, p. 1279-1287 9 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Down-regulation of annexin A10 in hepatocellular carcinoma is associated with vascular invasion, early recurrence, and poor prognosis in synergy with p53 mutation

  Liu, S. H., Lin, C-Y., Peng, S. Y., Jeng, Y. M., Pan, H. W., Lai, P. L., Liu, C. L. & Hsu, H. C., 2002, In: American Journal of Pathology. 160, 5, p. 1831-1837 7 p.

  Research output: Contribution to journal › Article › peer-review
  74 Citations (Scopus)

• Downregulation of angiotensin converting enzyme II is associated with pacing-induced sustained atrial fibrillation

  Pan, C. H., Lin, J. L., Lai, L. P., Chen, C. L., Stephen Huang, S. K. & Lin, C. S., Feb 6 2007, In: FEBS Letters. 581, 3, p. 526-534 9 p.

  Research output: Contribution to journal › Article › peer-review
  44 Citations (Scopus)

• Downregulation of alpha-fetoprotein expression by LHX4: A critical role in hepatocarcinogenesis

  Hung, T. M., Hu, R. H., Ho, C. M., Chiu, Y. L., Lee, J. L., Jeng, Y. M., Shih, T-B. & Lee, P. H., Dec 2011, In: Carcinogenesis. 32, 12, p. 1815-1823 9 p., bgr219.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses

  Chang, J. H., Cheng, C. W., Yang, Y. C., Chen, W. S., Hung, W. Y., Chow, J. M., Chen, P. S., Hsiao, M., Lee, W. J. & Chien, M. H., Aug 22 2018, In: Journal of Experimental and Clinical Cancer Research. 37, 1, p. 199 199.

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)

• Downregulated myocardial connexin 43 and suppressed contractility in rabbits subjected to a cholesterol-enriched diet

  Lin, L. C., Wu, C. C., Yeh, H. I., Lu, L. S., Liu, Y. B., Lin, S. F. & Lee, Y. T., Oct 2005, In: Laboratory Investigation. 85, 10, p. 1224-1237 14 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Downregulated MTAP expression in myxofibrosarcoma: A characterization of inactivating mechanisms, tumor suppressive function, and therapeutic relevance

  Li, C. F., Fang, F. M., Kung, H. J., Chen, L. T., Wang, J. W., Tsai, J. W., Yu, S. C., Wang, Y. H., Li, S. H. & Huang, H. Y., Jan 1 2014, In: Oncotarget. 5, 22, p. 11428-11441 14 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Downregulated miR329 and miR410 promote the proliferation and invasion of oral squamous cell carcinoma by targeting Wnt-7b

  Shiah, S. G., Hsiao, J. R., Chang, W. M., Chen, Y. W., Jin, Y. T., Wong, T. Y., Huang, J. S., Tsai, S. T., Hsu, Y. M., Chou, S. T., Yen, Y. C., Jiang, S. S., Shieh, Y. S., Chang, I. S., Hsiao, M. & Chang, J. Y., Dec 15 2014, In: Cancer Research. 74, 24, p. 7560-7572 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  96 Citations (Scopus)

• Downexpression of Matriptase-2 Correlates with Tumor Progression and Clinical Prognosis in Oral Squamous-Cell Carcinoma

  Cheng, M. F., Lin, L. H., Huang, M. S., Lee, H. S., Ji, D. D., Lin, C. S. & Hsia, K. T., 2017, In: Applied Immunohistochemistry and Molecular Morphology. 25, 7, p. 481-488 8 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status

  Gaur, S., Chen, L., Ann, V., Lin, W. C., Wang, Y., Chang, V. H. S., Hsu, N. Y., Shia, H. S. & Yen, Y., Feb 4 2014, In: Molecular Cancer. 13, 1, 21.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Dovitinib Acts As a Novel Radiosensitizer in Hepatocellular Carcinoma by Targeting SHP-1/STAT3 Signaling

  Huang, C. Y., Tai, W. T., Wu, S-Y., Shih, C. T., Chen, M. H., Tsai, M. H., Kuo, C. W., Shiau, C. W., Hung, M. H. & Chen, K. F., Jun 1 2016, In: International Journal of Radiation Oncology Biology Physics. 95, 2, p. 761-71 11 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)