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• Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers

  Chi, J. Y., Hsiao, Y. W., Li, C. F., Lo, Y. C., Lin, Z. Y., Hong, J. Y., Liu, Y. M., Han, X., Wang, S. M., Chen, B. K., Tsai, K-C. & Wang, J. M., 2015, In: Oncotarget. 6, 27, p. 23987-24001 15 p.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Targeting c-Myc as a novel approach for hepatocellular carcinoma

  Lin, C. P., Liu, C. R., Lee, C. N., Chan, T. S. & Liu, H. E., 2010, In: World Journal of Hepatology. 2, 1, p. 16-20 5 p.

  Research output: Contribution to journal › Article › peer-review
  93 Citations (Scopus)

• Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis

  Lee, Y. C., Jin, J. K., Cheng, C. J., Huang, C. F., Song, J. H., Huang, M., Brown, W. S., Zhang, S., Yu-Lee, L. Y., Yeh, E. T., McIntyre, B. W., Logothetis, C. J., Gallick, G. E. & Lin, S. H., Apr 2013, In: Molecular Cancer Research. 11, 4, p. 405-417 13 p.

  Research output: Contribution to journal › Article › peer-review
  63 Citations (Scopus)

• Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model

  Bisanz, K., Yu, J., Edlund, M., Spohn, B., Hung, M. C., Chung, L. W. K. & Hsieh, C. L., Oct 2005, In: Molecular Therapy. 12, 4, p. 634-643 10 p.

  Research output: Contribution to journal › Article › peer-review
  73 Citations (Scopus)

• Targeting efficiency and biodistribution of biotinylated-EGF-conjugated gelatin nanoparticles administered via aerosol delivery in nude mice with lung cancer

  Tseng, C. L., Wu, S. Y. H., Wang, W. H., Peng, C. L., Lin, F. H., Lin, C. C., Young, T. H. & Shieh, M. J., Jul 2008, In: Biomaterials. 29, 20, p. 3014-3022 9 p.

  Research output: Contribution to journal › Article › peer-review
  118 Citations (Scopus)

• Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis

  Lin, S. L., Chang, F. C., Schrimpf, C., Chen, Y. T., Wu, C. F., Wu, V. C., Chiang, W. C., Kuhnert, F., Kuo, C. J., Chen, Y. M., Wu, K. D., Tsai, T. J. & Duffield, J. S., Feb 2011, In: American Journal of Pathology. 178, 2, p. 911-923 13 p.

  Research output: Contribution to journal › Article › peer-review
  190 Citations (Scopus)

• Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator

  Lee, K. H., Hsu, E. C., Guh, J. H., Yang, H. C., Wang, D., Kulp, S. K., Shapiro, C. L. & Chen, C. S., Nov 11 2011, In: Journal of Biological Chemistry. 286, 45, p. 39247-39258 12 p.

  Research output: Contribution to journal › Article › peer-review
  80 Citations (Scopus)

• Targeting epidermal growth factor receptor in lung cancer: Perspective from the Asia-Pacific region

  Liu, H. E., Lim, K. H., Huang, M. J. & Huang, B. S., Mar 2006, In: Asia-Pacific Journal of Clinical Oncology. 2, 1, p. 22-31 10 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Targeting FAT1 inhibits carcinogenesis, induces oxidative stress and enhances cisplatin sensitivity through deregulation of LRP5/WNT2/GSS signaling axis in oral squamous cell carcinoma

  Hsu, T. N., Huang, C. M., Huang, C. S., Huang, M. S., Yeh, C. T., Chao, T. Y. & Bamodu, O. A., Dec 2019, In: Cancers. 11, 12, 1883.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Citations (Scopus)

• Targeting fibrinogen-like protein 1 is a novel therapeutic strategy to combat obesity

  Wu, H. T., Chen, S. C., Fan, K. C., Kuo, C. H., Lin, S. Y., Wang, S. H., Chang, C. J. & Li, H. Y., Feb 1 2020, In: FASEB Journal. 34, 2, p. 2958-2967 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• Targeting galectin-1 impairs castration-resistant prostate cancer progression and invasion

  Shih, T-C., Liu, R., Wu, C-T., Li, X., Xiao, W., Deng, X., Kiss, S., Wang, T., Chen, X-J., Carney, R., Kung, H-J., Duan, Y., Ghosh, P. M. & Lam, K. S., 2018, In: Clinical Cancer Research. 24, 17, p. 4319-4331 13 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression

  Wu, M. H., Hong, H. C., Hong, T. M., Chiang, W. F., Jin, Y. T. & Chen, Y. L., Mar 15 2011, In: Clinical Cancer Research. 17, 6, p. 1306-1316 11 p.

  Research output: Contribution to journal › Article › peer-review
  95 Citations (Scopus)

• Targeting heat shock factor 1 as an antiviral strategy against dengue virus replication in vitro and in vivo

  Tsai, T. T., Chen, C. L., Tsai, C. C. & Lin, C. F., Sep 1 2017, In: Antiviral Research. 145, p. 44-53 10 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Targeting histone deacetylases: A novel therapeutic strategy for atrial fibrillation

  Lkhagva, B., Kao, Y. H., Chen, Y. C., Chao, T. F., Chen, S. A. & Chen, Y. J., 2016, In: European Journal of Pharmacology. 781, p. 250-257 8 p.

  Research output: Contribution to journal › Review article › peer-review
  14 Citations (Scopus)

• Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21

  Chen, S. M., Lin, T. K., Tseng, Y. Y., Tu, C. H., Lui, T. N., Huang, S. F., Hsieh, L. L. & Li, Y. Y., Aug 2018, In: Cancer Medicine. 7, 8, p. 3988-4003 16 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer

  Wang, H. H., Wang, Y. C., Wu, D-W., Hung, C. S., Chen, C. Y. & Lee, H., Apr 1 2017, In: Tumor Biology. 39, 4

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Targeting Interleukin 15 protects brain from cerebral ischemia-reperfusion injury

  Lee, G-A., Lin, T. N. & Liao, N. S., Jun 2018.

  Research output: Contribution to conference › Paper › peer-review

• Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castrationresistant prostate cancer

  Wu, M. J., Chen, C. J., Lin, T. Y., Liu, Y. Y., Tseng, L. L., Cheng, M. L., Chuu, C. P., Tsai, H. K., Kuo, W. L., Kung, H. J. & Wang, W. C., 2021, In: Theranostics. 11, 16, p. 7779-7796 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Targeting L1 cell adhesion molecule expression using liposomeencapsulated siRNA suppresses prostate cancer bone metastasis and growth

  Sung, S. Y., Wu, I. H., Chuang, P. H., Petros, J. A., Wu, H. C., Zeng, H. J., Huang, W. C., Chung, L. W. K. & Hsieh, C. L., 2014, In: Oncotarget. 5, 20, p. 9911-9929 19 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Targeting L1 cell adhesion molecule using lentivirus-mediated short hairpin RNA interference reverses aggressiveness of oral squamous cell carcinoma

  Hung, S. C., Wu, I. H., Hsue, S. S., Liao, C. H., Wang, H. C., Chuang, P. H., Sung, S. Y. & Hsieh, C. L., Dec 6 2010, In: Molecular Pharmaceutics. 7, 6, p. 2312-2323 12 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Targeting LncRNA HOTAIR suppresses cancer stemness and metastasis in oral carcinomas stem cells through modulation of EMT

  Lu, M. Y., Liao, Y. W., Chen, P. Y., Hsieh, P. L., Fang, C. Y., Wu, C. Y., Yen, M. L., Peng, B. Y., Wang, D. P., Cheng, H. C., Wu, C. Z., Shih, Y. H., Wang, D. J., Yu, C. C. & Tsai, L. L., Jan 1 2017, In: Oncotarget. 8, 58, p. 98542-98552 11 p.

  Research output: Contribution to journal › Article › peer-review
  48 Citations (Scopus)

• Targeting Mac-1-mediated leukocyte–RBC interactions uncouples the benefits for acute vaso-occlusion and chronic organ damage

  Chen, G. S., Chang, J-S., Zhang, D., Pinho, S., Jang, J. E. & Frenette, P. S., Oct 1 2016, In: Experimental Hematology. 44, 10, p. 940-946 7 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Targeting mammalian target of rapamycin (mTOR) for health and diseases

  Tsang, C. K., Qi, H., Liu, L. F. & Zheng, X. F. S., Feb 2007, In: Drug Discovery Today. 12, 3-4, p. 112-124 13 p.

  Research output: Contribution to journal › Review article › peer-review
  336 Citations (Scopus)

• Targeting mitochondrial oxphos and their regulatory signals in prostate cancers

  Chen, C. L., Lin, C. Y. & Kung, H. J., Dec 1 2021, In: International journal of molecular sciences. 22, 24, 13435.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Targeting myotonic dystrophy by preimplantation genetic diagnosis-karyomapping

  Wang, C. W., Liu, Y. L. & Chen, C. H., Jan 1 2019, (Accepted/In press) In: Taiwanese Journal of Obstetrics and Gynecology.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Targeting neuropilin 1 as an antitumor strategy in lung cancer

  Hong, T. M., Chen, Y. L., Wu, Y. Y., Yuan, A., Chao, Y. C., Chung, Y. C., Wu, M. H., Yang, S. C., Pan, S. H., Shih, J. Y., Chan, W. K. & Yang, P. C., Aug 15 2007, In: Clinical Cancer Research. 13, 16, p. 4759-4768 10 p.

  Research output: Contribution to journal › Article › peer-review
  148 Citations (Scopus)

• Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer

  Su, Y-H., Tang, W. C., Cheng, Y. W., Sia, P., Huang, C. C., Lee, Y. C., Jiang, H. Y., Wu, M. H., Lai, I. L., Lee, J. W. & Lee, K. H., Oct 1 2015, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2261-2272 12 p.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)

• Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer

  Lee, Y. C., Lee, C. H., Tsai, H. P., An, H. W., Lee, C-M., Wu, J. C., Chen, C. S., Huang, S. H., Hwang, J., Cheng, K. T., Leiw, P. L., Chen, C. L. & Lin, C. M., Jul 24 2015, In: PLoS ONE. 10, 7, e0132579.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Targeting PML-RARα and oncogenic signaling pathways by Chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells

  Lai, T-I., Yao, C. J., Yang, C. M., Chuang, S. E., Yan, J. L., Liu, C. Y., Chen, S. W., Yan, K. H. & Lai, G. M., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 984154.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Targeting ribonucleotide reductase for cancer therapy

  Shao, J., Liu, X., Zhu, L. & Yen, Y., Dec 1 2013, In: Expert Opinion on Therapeutic Targets. 17, 12, p. 1423-1437 15 p.

  Research output: Contribution to journal › Review article › peer-review
  49 Citations (Scopus)

• Targeting ROS and cPLA2/COX2 Expressions Ameliorated Renal Damage in Obese Mice with Endotoxemia

  Chang, J. F., Yeh, J. C., Ho, C. T., Liu, S. H., Hsieh, C. Y., Wang, T. M., Chang, S. W., Lee, I. T., Huang, K. Y., Wang, J. Y. & Lin, W. N., Sep 6 2019, In: International Journal of Molecular Sciences. 20, 18, 4393.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Citations (Scopus)

• Targeting SHP-1-STAT3 signaling: A promising therapeutic approach for the treatment of cholangiocarcinoma

  Hu, M. H., Chen, L. J., Chen, Y. L., Tsai, M. S., Shiau, C. W., Chao, T. I., Liu, C. Y., Kao, J. H. & Chen, K. F., 2017, In: Oncotarget. 8, 39, p. 65077-65089 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  12 Citations (Scopus)

• Targeting spleen tyrosine kinase-bruton's tyrosine kinase axis for immunologically mediated glomerulonephritis

  Chen, J. S., Chang, L. C., Huang, S. J. & Cheng, C. W., 2014, In: BioMed Research International. 2014, 814869.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Targeting the CXCR4/CXCL12 axis in treating epithelial ovarian cancer

  Mao, T. L., Fan, K. F. & Liu, C. L., Oct 1 2017, In: Gene Therapy. 24, 10, p. 621-629 9 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters

  Lin, Y. S., Tungpradit, R., Sinchaikul, S., An, F. M., Liu, D. Z., Phutrakul, S. & Chen, S. T., Dec 11 2008, In: Journal of Medicinal Chemistry. 51, 23, p. 7428-7441 14 p.

  Research output: Contribution to journal › Article › peer-review
  79 Citations (Scopus)

• Targeting the Epigenetic Non-Coding RNA MALAT1/Wnt Signaling Axis as a Therapeutic Approach to Suppress Stemness and Metastasis in Hepatocellular Carcinoma

  Chang, H. L., Bamodu, O. A., Ong, J. R., Lee, W. H., Yeh, C. T. & Tsai, J. T., Apr 20 2020, In: Cells. 9, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access
  13 Citations (Scopus)

• Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer

  Tseng, L. L., Cheng, H. H., Yeh, T. S., Huang, S. C., Syu, Y. Y., Chuu, C. P., Yuh, C. H., Kung, H. J. & Wang, W. C., Oct 6 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 40, p. 24859-24866 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• Targeting the Interplay Between Cancer Fibroblasts, Mesenchymal Stem Cells, and Cancer Stem Cells in Desmoplastic Cancers

  Chan, T. S., Shaked, Y. & Tsai, K. K., Jul 31 2019, In: Frontiers in Oncology. 9, 688.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  43 Citations (Scopus)

• Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders

  Hung, W. L., Ho, C. T. & Pan, M. H., Feb 1 2020, In: Molecular Nutrition and Food Research. 64, 4, 1900550.

  Research output: Contribution to journal › Review article › peer-review
  16 Citations (Scopus)

• Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin b

  Huang, T. C., Chang, H. Y., Hsu, C. H., Kuo, W. H., Chang, K. J. & Juan, H. F., Apr 2008, In: Journal of Proteome Research. 7, 4, p. 1433-1444 12 p.

  Research output: Contribution to journal › Article › peer-review
  84 Citations (Scopus)

• Targeting the SPOCK1-snail/slug axis-mediated epithelial-to-mesenchymal transition by apigenin contributes to repression of prostate cancer metastasis

  Chien, M. H., Lin, Y. W., Wen, Y. C., Yang, Y. C., Hsiao, M., Chang, J. L., Huang, H. C. & Lee, W. J., Jun 10 2019, In: Journal of Experimental and Clinical Cancer Research. 38, 1, 246.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Citations (Scopus)

• Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies

  Lin, Y-F., Lai, T. C., Chang, C. K., Chen, C. L., Huang, M. S., Yang, C. J., Liu, H. G., Dong, J. J., Chou, Y. A., Teng, K. H., Chen, S. H., Tian, W. T., Jan, Y. H., Hsiao, M. & Liang, P. H., Sep 3 2013, In: Journal of Clinical Investigation. 123, 9, p. 3861-3875 15 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Targeting to overexpressed glucose-regulated protein 78 in gastric cancer discovered by 2D DIGE improves the diagnostic and therapeutic efficacy of micelles-mediated system

  Cheng, C. C., Lu, N., Peng, C. L., Chang, C. C., Mai, F. D., Chen, L. Y., Liao, M. H., Wang, W. M. & Chang, J., Aug 2012, In: Proteomics. 12, 15-16, p. 2584-2597 14 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Targeting TYRO3 inhibits epithelial-mesenchymal transition and increases drug sensitivity in colon cancer

  Chien, C-W., Hou, P-C., Wu, H-C., Chang, Y-L., Lin, S-C., Lin, S-C., Lin, B-W., Lee, J-C., Chang, Y-J., Sun, H. S. & Tsai, S-J., Nov 10 2016, In: Oncogene. 35, 45, p. 5872-5881 10 p.

  Research output: Contribution to journal › Article › peer-review
  40 Citations (Scopus)

• Targeting Tyrosine Kinases and Autophagy in Prostate Cancer

  Kung, H. J., Feb 1 2011, In: Hormones and Cancer. 2, 1, p. 38-46 9 p.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• Targeting β-tubulin: CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca²⁺ entry, mitochondrial perturbation and caspase overactivation

  Lin, Y-F., Lee, Y. F. & Liang, P. H., Nov 2012, In: Cell Death and Disease. 3, 11, e434.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• Tartrate-Resistant Acid Phosphatase 5a Activity as a Novel Biomarker for Flare of Systemic Lupus Erythematosus

  Chen, J. H., Wu, Y. Y., Huang, T. C., Lu, C. C., Liu, F. C., Janckila, A. J. & Chao, T-Y., Feb 2017, In: Academia Journal of Biotechnology. 5, 2, 6 p.

  Research output: Contribution to journal › Article › peer-review

• Tartrate-resistant acid phosphatase 5a in sarcoidosis: Further evidence for a novel macrophage biomarker in chronic inflammation

  Wu, Y. Y., Janckila, A. J., Slone, S. P., Perng, W. C. & Chao, T. Y., 2014, In: Journal of the Formosan Medical Association = Taiwan yi zhi. 113, 6, p. 364-370 7 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• Tartrate-resistant acid phosphatase 5b activity is a useful bone marker for monitoring bone metastases in breast cancer patients after treatment

  Chung, Y. C., Ku, C. H., Chao, T. Y., Yu, J. C., Chen, M. M. & Lee, S. H., Mar 2006, In: Cancer Epidemiology Biomarkers and Prevention. 15, 3, p. 424-428 5 p.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Tartrate-resistant acid phosphatase 5b as a serum marker of bone metastasis in breast cancer patients

  Chao, T. Y., Ho, C. L., Lee, S. H., Chen, M. M. J., Janckila, A. & Yam, L. T., 2004, In: Journal of Biomedical Science. 11, 4, p. 511-516 6 p.

  Research output: Contribution to journal › Article › peer-review
  30 Citations (Scopus)