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• Targeted delivery of paclitaxel and doxorubicin to cancer xenografts via the nanoparticle of nano-diamino-tetrac

  Sudha, T., Bharali, D. J., Yalcin, M., Darwish, N. H. E., Coskun, M. D., Keating, K. A., Lin, H. Y., Davis, P. J. & Mousa, S. A., Feb 15 2017, In: International Journal of Nanomedicine. 12, p. 1305-1315 11 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• Targeted delivery system for juxtacrine signaling growth factor based on rhBMP-2-mediated carrier-protein conjugation

  Liu, H. W., Chen, C. H., Tsai, C. L. & Hsiue, G. H., Oct 2006, In: Bone. 39, 4, p. 825-836 12 p.

  Research output: Contribution to journal › Article › peer-review
  40 Citations (Scopus)

• Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice

  Wu, L. S., Cheng, W. C. & Shen, C. K. J., Aug 10 2012, In: Journal of Biological Chemistry. 287, 33, p. 27335-27344 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  106 Citations (Scopus)

• Targeted Disruption in Mice of a Neural Stem Cell-Maintaining, KRAB-Zn Finger-Encoding Gene That Has Rapidly Evolved in the Human Lineage

  Chien, H. C., Wang, H. Y., Su, Y. N., Lai, K. Y., Lu, L. C., Chen, P. C., Tsai, S. F., Wu, C. I., Hsieh, W. S. & Shen, C. K. J., Oct 10 2012, In: PLoS ONE. 7, 10, e47481.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  10 Citations (Scopus)

• Targeted disruption of nebulette protein expression alters cardiac myofibril assembly and function

  Moncman, C. L. & Wang, K., 2002, In: Experimental Cell Research. 273, 2, p. 204-218 15 p.

  Research output: Contribution to journal › Article › peer-review
  44 Citations (Scopus)

• Targeted gene delivery to alveolar macrophages via Fc receptor-mediated endocytosis

  Rojanasakul, Y., Wang, L. Y., Malanga, C. J., Ma, J. K. H. & Liaw, J., 1994, In: Pharmaceutical Research. 11, 12, p. 1731-1736 6 p.

  Research output: Contribution to journal › Article › peer-review
  38 Citations (Scopus)

• Targeted gene delivery via the folate receptor in Polymeric Gene Delivery

  Chiu, S-J. & Lee, J-A., 2004, Polymeric Gene Delivery: Principles and Applications. CRC Press/Balkema, p. 523-536 14 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Targeted mass CPR training for families of cardiac patients - Experience in Taipei city

  Cheng, Y. C., Hu, S. C., Yen, D., Kao, W. F. & Lee, C. H., 1997, In: Tzu Chi Medical Journal. 9, 4, p. 273-278 6 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Targeted methylation of CMV and E1A viral promoters

  Hsu, C. C., Li, H. P., Hung, Y. H., Leu, Y. W., Wu, W. H., Wang, F. S., Lee, K. D., Chang, P. J., Wu, C. S., Lu, Y. J., Huang, T. H. M., Chang, Y. S. & Hsiao, S. H., Nov 12 2010, In: Biochemical and Biophysical Research Communications. 402, 2, p. 228-234 7 p.

  Research output: Contribution to journal › Article › peer-review
  49 Citations (Scopus)

• Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells

  Teng, I. W., Hou, P. C., Lee, K. D., Chu, P. Y., Yeh, K. T., Jin, V. X., Tseng, M. J., Tsai, S. J., Chang, Y. S., Wu, C. S., Sun, H. S., Tsai, K. D., Jeng, L. B., Nephew, K. P., Huang, T. H. M., Hsiao, S. H. & Leu, Y. W., Jul 1 2011, In: Cancer Research. 71, 13, p. 4653-4663 11 p.

  Research output: Contribution to journal › Article › peer-review
  81 Citations (Scopus)

• Targeted PARP Inhibition Combined with FGFR1 Blockade is Synthetically Lethal to Malignant Cells in Patients with Pancreatic Cancer

  Lai, S. W., Bamodu, O. A., Chen, J. H., Wu, A. T., Lee, W. H., Chao, T. Y. & Yeh, C. T., Apr 8 2020, In: Cells. 9, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• Targeted temperature management in severe middle cerebral artery infarction-related out-of-hospital cardiac arrest

  Wang, A. Y., Wu, T. H., Kao, Y. T. & Huang, C. Y., Jun 1 2019, In: Journal of the Formosan Medical Association. 118, 6, p. 1073-1075 3 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

• Targeted treatment of primary aldosteronism – The consensus of Taiwan Society of Aldosteronism

  TAIPAI, Taiwan Primary Aldosteronism Investigator, Jan 2019, In: Journal of the Formosan Medical Association. 118, 1P1, p. 72-82 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Citations (Scopus)

• Targeting annexin A2 reduces tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma

  Chen, C. Y., Lin, Y-S., Chen, C. L., Chao, P. Z., Chiou, J. F., Kuo, C. C., Lee, F. P., Lin, Y. F., Sung, Y. H., Lin, Y. T., Li, C. F., Chen, Y. J. & Chen, C. H., 2015, In: Oncotarget. 6, 29, p. 26946-26959 14 p.

  Research output: Contribution to journal › Article › peer-review
  31 Citations (Scopus)

• Targeting Autophagy Augments BBR-Mediated Cell Death in Human Hepatoma Cells Harboring Hepatitis C Virus RNA

  Tai, C. J., Jassey, A., Liu, C. H., Tai, C. J., Richardson, C. D., Wong, S. H. & Lin, L. T., Apr 8 2020, In: Cells. 9, 4

  Research output: Contribution to journal › Article › peer-review

  Open Access
  5 Citations (Scopus)

• Targeting autophagy by MPT0L145, a highly potent pik3c3 inhibitor, provides synergistic interaction to targeted or chemotherapeutic agents in cancer cells

  Chen, C. H., Hsieh, T. H., Lin, Y. C., Liu, Y. R., Liou, J. P. & Yen, Y., Sep 2019, In: Cancers. 11, 9, 1345.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• Targeting autophagy overcomes Enzalutamide resistance in castration-resistant prostate cancer cells and improves therapeutic response in a xenograft model

  Nguyen, H. G., Yang, J. C., Kung, H. J., Shi, X. B., Tilki, D., Lara, P. N., Devere White, R. W., Gao, A. C. & Evans, C. P., Sep 4 2014, In: Oncogene. 33, 36, p. 4521-4530 10 p.

  Research output: Contribution to journal › Article › peer-review
  117 Citations (Scopus)

• Targeting BC200/miR218-5p Signaling Axis for Overcoming Temozolomide Resistance and Suppressing Glioma Stemness

  Su, Y. K., Lin, J. W., Shih, J. W., Chuang, H. Y., Fong, I. H., Yeh, C-T. & Lin, C-M., Aug 8 2020, In: Cells. 9, 8

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Citations (Scopus)

• Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor

  Guo, W., Liu, R., Bhardwaj, G., Yang, J. C., Changou, C., Ma, A. H., Mazloom, A., Chintapalli, S., Xiao, K., Xiao, W., Kumaresan, P., Sanchez, E., Yeh, C. T., Evans, C. P., Patterson, R., Lam, K. S. & Kung, H. J., Jan 1 2014, In: Cell Death and Disease. 5, 9, e1409.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Targeting cancer stem cells from a metabolic perspective

  Shen, Y. A., Pan, S. C., Chu, I., Lai, R. Y. & Wei, Y. H., Mar 1 2020, In: Experimental Biology and Medicine. 245, 5, p. 465-476 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  9 Citations (Scopus)

• Targeting cancer stem cells in breast cancer: Potential anticancer properties of 6-shogaol and pterostilbene

  Wu, C. H., Hong, B. H., Ho, C. T. & Yen, G. C., 2015, In: Journal of Agricultural and Food Chemistry. 63, 9, p. 2432-2441 10 p.

  Research output: Contribution to journal › Article › peer-review
  55 Citations (Scopus)

• Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers

  Chi, J. Y., Hsiao, Y. W., Li, C. F., Lo, Y. C., Lin, Z. Y., Hong, J. Y., Liu, Y. M., Han, X., Wang, S. M., Chen, B. K., Tsai, K-C. & Wang, J. M., 2015, In: Oncotarget. 6, 27, p. 23987-24001 15 p.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Targeting c-Myc as a novel approach for hepatocellular carcinoma

  Lin, C. P., Liu, C. R., Lee, C. N., Chan, T. S. & Liu, H. E., 2010, In: World Journal of Hepatology. 2, 1, p. 16-20 5 p.

  Research output: Contribution to journal › Article › peer-review
  93 Citations (Scopus)

• Targeting constitutively activated β1 integrins inhibits prostate cancer metastasis

  Lee, Y. C., Jin, J. K., Cheng, C. J., Huang, C. F., Song, J. H., Huang, M., Brown, W. S., Zhang, S., Yu-Lee, L. Y., Yeh, E. T., McIntyre, B. W., Logothetis, C. J., Gallick, G. E. & Lin, S. H., Apr 2013, In: Molecular Cancer Research. 11, 4, p. 405-417 13 p.

  Research output: Contribution to journal › Article › peer-review
  63 Citations (Scopus)

• Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model

  Bisanz, K., Yu, J., Edlund, M., Spohn, B., Hung, M. C., Chung, L. W. K. & Hsieh, C. L., Oct 2005, In: Molecular Therapy. 12, 4, p. 634-643 10 p.

  Research output: Contribution to journal › Article › peer-review
  73 Citations (Scopus)

• Targeting efficiency and biodistribution of biotinylated-EGF-conjugated gelatin nanoparticles administered via aerosol delivery in nude mice with lung cancer

  Tseng, C. L., Wu, S. Y. H., Wang, W. H., Peng, C. L., Lin, F. H., Lin, C. C., Young, T. H. & Shieh, M. J., Jul 2008, In: Biomaterials. 29, 20, p. 3014-3022 9 p.

  Research output: Contribution to journal › Article › peer-review
  118 Citations (Scopus)

• Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis

  Lin, S. L., Chang, F. C., Schrimpf, C., Chen, Y. T., Wu, C. F., Wu, V. C., Chiang, W. C., Kuhnert, F., Kuo, C. J., Chen, Y. M., Wu, K. D., Tsai, T. J. & Duffield, J. S., Feb 2011, In: American Journal of Pathology. 178, 2, p. 911-923 13 p.

  Research output: Contribution to journal › Article › peer-review
  190 Citations (Scopus)

• Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator

  Lee, K. H., Hsu, E. C., Guh, J. H., Yang, H. C., Wang, D., Kulp, S. K., Shapiro, C. L. & Chen, C. S., Nov 11 2011, In: Journal of Biological Chemistry. 286, 45, p. 39247-39258 12 p.

  Research output: Contribution to journal › Article › peer-review
  80 Citations (Scopus)

• Targeting epidermal growth factor receptor in lung cancer: Perspective from the Asia-Pacific region

  Liu, H. E., Lim, K. H., Huang, M. J. & Huang, B. S., Mar 2006, In: Asia-Pacific Journal of Clinical Oncology. 2, 1, p. 22-31 10 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• Targeting FAT1 inhibits carcinogenesis, induces oxidative stress and enhances cisplatin sensitivity through deregulation of LRP5/WNT2/GSS signaling axis in oral squamous cell carcinoma

  Hsu, T. N., Huang, C. M., Huang, C. S., Huang, M. S., Yeh, C. T., Chao, T. Y. & Bamodu, O. A., Dec 2019, In: Cancers. 11, 12, 1883.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Citations (Scopus)

• Targeting fibrinogen-like protein 1 is a novel therapeutic strategy to combat obesity

  Wu, H. T., Chen, S. C., Fan, K. C., Kuo, C. H., Lin, S. Y., Wang, S. H., Chang, C. J. & Li, H. Y., Feb 1 2020, In: FASEB Journal. 34, 2, p. 2958-2967 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• Targeting galectin-1 impairs castration-resistant prostate cancer progression and invasion

  Shih, T-C., Liu, R., Wu, C-T., Li, X., Xiao, W., Deng, X., Kiss, S., Wang, T., Chen, X-J., Carney, R., Kung, H-J., Duan, Y., Ghosh, P. M. & Lam, K. S., 2018, In: Clinical Cancer Research. 24, 17, p. 4319-4331 13 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression

  Wu, M. H., Hong, H. C., Hong, T. M., Chiang, W. F., Jin, Y. T. & Chen, Y. L., Mar 15 2011, In: Clinical Cancer Research. 17, 6, p. 1306-1316 11 p.

  Research output: Contribution to journal › Article › peer-review
  95 Citations (Scopus)

• Targeting heat shock factor 1 as an antiviral strategy against dengue virus replication in vitro and in vivo

  Tsai, T. T., Chen, C. L., Tsai, C. C. & Lin, C. F., Sep 1 2017, In: Antiviral Research. 145, p. 44-53 10 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• Targeting histone deacetylases: A novel therapeutic strategy for atrial fibrillation

  Lkhagva, B., Kao, Y. H., Chen, Y. C., Chao, T. F., Chen, S. A. & Chen, Y. J., 2016, In: European Journal of Pharmacology. 781, p. 250-257 8 p.

  Research output: Contribution to journal › Review article › peer-review
  14 Citations (Scopus)

• Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21

  Chen, S. M., Lin, T. K., Tseng, Y. Y., Tu, C. H., Lui, T. N., Huang, S. F., Hsieh, L. L. & Li, Y. Y., Aug 2018, In: Cancer Medicine. 7, 8, p. 3988-4003 16 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Targeting insulin-like growth factor-binding protein-3 by microRNA-125b promotes tumor invasion and poor outcomes in non-small-cell lung cancer

  Wang, H. H., Wang, Y. C., Wu, D-W., Hung, C. S., Chen, C. Y. & Lee, H., Apr 1 2017, In: Tumor Biology. 39, 4

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• Targeting Interleukin 15 protects brain from cerebral ischemia-reperfusion injury

  Lee, G-A., Lin, T. N. & Liao, N. S., Jun 2018.

  Research output: Contribution to conference › Paper › peer-review

• Targeting KDM4B that coactivates c-Myc-regulated metabolism to suppress tumor growth in castrationresistant prostate cancer

  Wu, M. J., Chen, C. J., Lin, T. Y., Liu, Y. Y., Tseng, L. L., Cheng, M. L., Chuu, C. P., Tsai, H. K., Kuo, W. L., Kung, H. J. & Wang, W. C., 2021, In: Theranostics. 11, 16, p. 7779-7796 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• Targeting L1 cell adhesion molecule expression using liposomeencapsulated siRNA suppresses prostate cancer bone metastasis and growth

  Sung, S. Y., Wu, I. H., Chuang, P. H., Petros, J. A., Wu, H. C., Zeng, H. J., Huang, W. C., Chung, L. W. K. & Hsieh, C. L., 2014, In: Oncotarget. 5, 20, p. 9911-9929 19 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Targeting L1 cell adhesion molecule using lentivirus-mediated short hairpin RNA interference reverses aggressiveness of oral squamous cell carcinoma

  Hung, S. C., Wu, I. H., Hsue, S. S., Liao, C. H., Wang, H. C., Chuang, P. H., Sung, S. Y. & Hsieh, C. L., Dec 6 2010, In: Molecular Pharmaceutics. 7, 6, p. 2312-2323 12 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Targeting LncRNA HOTAIR suppresses cancer stemness and metastasis in oral carcinomas stem cells through modulation of EMT

  Lu, M. Y., Liao, Y. W., Chen, P. Y., Hsieh, P. L., Fang, C. Y., Wu, C. Y., Yen, M. L., Peng, B. Y., Wang, D. P., Cheng, H. C., Wu, C. Z., Shih, Y. H., Wang, D. J., Yu, C. C. & Tsai, L. L., Jan 1 2017, In: Oncotarget. 8, 58, p. 98542-98552 11 p.

  Research output: Contribution to journal › Article › peer-review
  48 Citations (Scopus)

• Targeting Mac-1-mediated leukocyte–RBC interactions uncouples the benefits for acute vaso-occlusion and chronic organ damage

  Chen, G. S., Chang, J-S., Zhang, D., Pinho, S., Jang, J. E. & Frenette, P. S., Oct 1 2016, In: Experimental Hematology. 44, 10, p. 940-946 7 p.

  Research output: Contribution to journal › Article › peer-review
  11 Citations (Scopus)

• Targeting mammalian target of rapamycin (mTOR) for health and diseases

  Tsang, C. K., Qi, H., Liu, L. F. & Zheng, X. F. S., Feb 2007, In: Drug Discovery Today. 12, 3-4, p. 112-124 13 p.

  Research output: Contribution to journal › Review article › peer-review
  335 Citations (Scopus)

• Targeting mitochondrial oxphos and their regulatory signals in prostate cancers

  Chen, C. L., Lin, C. Y. & Kung, H. J., Dec 1 2021, In: International journal of molecular sciences. 22, 24, 13435.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Targeting myotonic dystrophy by preimplantation genetic diagnosis-karyomapping

  Wang, C. W., Liu, Y. L. & Chen, C. H., Jan 1 2019, (Accepted/In press) In: Taiwanese Journal of Obstetrics and Gynecology.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Targeting neuropilin 1 as an antitumor strategy in lung cancer

  Hong, T. M., Chen, Y. L., Wu, Y. Y., Yuan, A., Chao, Y. C., Chung, Y. C., Wu, M. H., Yang, S. C., Pan, S. H., Shih, J. Y., Chan, W. K. & Yang, P. C., Aug 15 2007, In: Clinical Cancer Research. 13, 16, p. 4759-4768 10 p.

  Research output: Contribution to journal › Article › peer-review
  148 Citations (Scopus)

• Targeting of multiple oncogenic signaling pathways by Hsp90 inhibitor alone or in combination with berberine for treatment of colorectal cancer

  Su, Y-H., Tang, W. C., Cheng, Y. W., Sia, P., Huang, C. C., Lee, Y. C., Jiang, H. Y., Wu, M. H., Lai, I. L., Lee, J. W. & Lee, K. H., Oct 1 2015, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1853, 10, p. 2261-2272 12 p.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)

• Targeting of Topoisomerase I for Prognoses and Therapeutics of Camptothecin-Resistant Ovarian Cancer

  Lee, Y. C., Lee, C. H., Tsai, H. P., An, H. W., Lee, C-M., Wu, J. C., Chen, C. S., Huang, S. H., Hwang, J., Cheng, K. T., Leiw, P. L., Chen, C. L. & Lin, C. M., Jul 24 2015, In: PLoS ONE. 10, 7, e0132579.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Targeting PML-RARα and oncogenic signaling pathways by Chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells

  Lai, T-I., Yao, C. J., Yang, C. M., Chuang, S. E., Yan, J. L., Liu, C. Y., Chen, S. W., Yan, K. H. & Lai, G. M., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 984154.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)