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  • Ray-Jade Chen
2019

Upregulation of IGF-IIRα intensifies doxorubicin-induced cardiac damage

Pandey, S., Kuo, W. W., Ho, T. J., Yeh, Y. L., Shen, C. Y., Chen, R. J., Chang, R. L., Pai, P. Y., Padma, V. V., Huang, C. Y. & Huang, C. Y., Jan 1 2019, In : Journal of Cellular Biochemistry. 120, 10, p. 16956-16966 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2016

Alpinate Oxyphyllae Fructus Inhibits IGFII-Related Signaling Pathway to Attenuate Ang II-Induced Pathological Hypertrophy in H9c2 Cardiomyoblasts

Tsai, C. T., Chang, Y. M., Lin, S. L., Chen, Y. S., Yeh, Y. L., Padma, V. V., Tsai, C. C., Chen, R. J., Ho, T. J. & Huang, C. Y., Mar 1 2016, In : Journal of Medicinal Food. 19, 3, p. 300-309 10 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2019
Open Access
3 Citations (Scopus)
2017

Protective effect of HDL on NADPH oxidase-derived super oxide anion mediates hypoxia-induced cardiomyocyte apoptosis

Wen, S. Y., Tamilselvi, S., Shen, C. Y., Day, C. H., Chun, L. C., Cheng, L. Y., Ou, H. C., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Jun 1 2017, In : PLoS One. 12, 6, e0179492.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

The multifaceted link between inflammation and human diseases

Rajendran, P., Chen, Y. F., Chen, Y. F., Chung, L. C., Tamilselvi, S., Shen, C. Y., Day, C. H., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

28 Citations (Scopus)
2019

Resveratrol increases stem cell function in the treatment of damaged pancreas

Chen, T. S., Kuo, C. H., Day, C. H., Pan, L. F., Chen, R. J., Chen, B. C., Padma, V. V., Lin, Y. M. & Huang, C. Y., Nov 2019, In : Journal of Cellular Physiology. 234, 11, p. 20443-20452 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018
Open Access
2017

High density lipoprotein (HDL) reverses palmitic acid induced energy metabolism imbalance by switching CD36 and GLUT4 signaling pathways in cardiomyocyte

Wen, S. Y., Velmurugan, B. K., Day, C. H., Shen, C. Y., Chun, L. C., Tsai, Y. C., Lin, Y. M., Chen, R. J., Kuo, C. H. & Huang, C. Y., 2017, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018
2 Citations (Scopus)
2019

Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation

Li, J. Y., Chen, R. J., Huang, L. T., Lee, T. Y., Lu, W. J. & Lin, K. H., Oct 18 2019, In : Journal of Clinical Medicine. 8, 10

Research output: Contribution to journalArticle

2018

HSF1 phosphorylation by ERK/GSK3 suppresses RNF126 to sustain IGF-IIR expression for hypertension-induced cardiomyocyte hypertrophy

Huang, C. Y., Lee, F. L., Peng, S. F., Lin, K. H., Chen, R. J., Ho, T. J., Tsai, F. J., Padma, V. V., Kuo, W. W. & Huang, C. Y., Feb 2018, In : Journal of Cellular Physiology. 233, 2, p. 979-989

Research output: Contribution to journalArticle

17 Citations (Scopus)
2019

Deep sea minerals ameliorate diabetic-induced inflammation via inhibition of TNFα signaling pathways

Lu, C. H., Ou, H. C., Day, C. H., Chen, H. I., Pai, P. Y., Lee, C. Y., Chen, R. J., Chang, R. L., PadmaViswanadha, V., Hsieh, D. J. Y. & Huang, C. Y., Jan 1 2019, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

2016

Inhibition of NF-κB and metastasis in irinotecan (CPT-11)-resistant LoVo colon cancer cells by thymoquinone via JNK and p38

Chen, M. C., Lee, N. H., Hsu, H. H., Ho, T. J., Tu, C. C., Chen, R. J., Lin, Y. M., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., 2016, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2018

The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model mice

Lin, K. H., Chiu, C. H., Kuo, W. W., Ju, D. T., Shen, C. Y., Chen, R. J., Lin, C. C., Viswanadha, V. P., Liu, J. S., Huang, R. F. S. & Huang, C. Y., Jan 2018, In : Environmental Toxicology. 33, 1, p. 83-92

Research output: Contribution to journalArticle

6 Citations (Scopus)
2017
2019

Lessons learned from isolated blunt major pancreatic injury: Surgical experience in one trauma centre

Lin, B. C., Chen, R. J. & Hwang, T. L., Jan 1 2019, In : Injury.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2017

Identification of epidermal growth factor receptor-positive glioblastoma using lipid-encapsulated targeted superparamagnetic iron oxide nanoparticles in vitro

Chen, H. L., Hsu, F. T., Kao, Y. C. J., Liu, H. S., Huang, W. Z., Lu, C. F., Tsai, P. H., Ali, A. A. A., Lee, G. A., Chen, R. J. & Chen, C. Y., Nov 22 2017, In : Journal of Nanobiotechnology. 15, 1, 86.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

Suppression of isoproterenol-induced apoptosis in H9c2 cardiomyoblast cells by daidzein through activation of Akt

Hu, W. S., Lin, Y. M., Kuo, W. W., Pan, L. F., Yeh, Y. L., Li, Y. H., Kuo, C. H., Chen, R. J., Vijaya Padma, V., Chen, T. S. & Huang, C. Y., 2016, In : Chinese Journal of Physiology. 59, 6, p. 323-330 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

E2/ER β enhances calcineurin protein degradation and PI3k/Akt/MDM2 signal transduction to inhibit ISO-induced myocardial cell apoptosis

Lin, K. H., Kuo, W. W., Shibu, M. A., Day, C. H., Hsieh, Y. L., Chung, L. C., Chen, R. J., Wen, S. Y., Viswanadha, V. P. & Huang, C. Y., Apr 24 2017, In : International Journal of Molecular Sciences. 18, 4, 892.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2018

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

Huang, C. Y., Kuo, C. H., Pai, P. Y., Ho, T. J., Lin, Y. M., Chen, R. J., Tsai, F. J., Vijaya Padma, V., Kuo, W. W. & Huang, C. Y., Feb 1 2018, In : Data in Brief. 16, p. 521-526 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts

Feng, C. C., Pandey, S., Lin, C. Y., Shen, C. Y., Chang, R. L., Chang, T. T., Chen, R. J., Viswanadha, V. P., Lin, Y. M. & Huang, C. Y., Jan 1 2018, In : Biomedicine and Pharmacotherapy. 97, p. 880-885 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Development of benzimidazole derivatives as novel anti-platelet drugs

Yao, W. C., Yuan, L. T., Yang, W. B., Hsia, C. H., Huang, L. T., Lee, T. Y., Sheu, J. R., Lu, W-J., Jayakumar, T. & Chen, R. J., Jan 1 2017, In : Current Pharmaceutical Biotechnology. 18, 7, p. 594-605 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
7 Citations (Scopus)
2016

Mechanism of Taiwan Mingjian Oolong Tea to Inhibit Isoproterenol-Induced Hypertrophy and Apoptosis in Cardiomyoblasts

Yeh, Y. L., Tsai, H. I., Cheng, S. M., Pai, P., Ho, T. J., Chen, R. J., Lai, C. H., Huang, P. J., Padma, V. V. & Huang, C. Y., Feb 1 2016, In : American Journal of Chinese Medicine. 44, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2017

Prostaglandin E2-induced COX-2 expressions via EP2 and EP4 signaling pathways in human LoVo colon cancer cells

Hsu, H. H., Lin, Y. M., Shen, C. Y., Shibu, M. A., Li, S. Y., Chang, S. H., Lin, C. C., Chen, R. J., Viswanadha, V. P., Shih, H. N. & Huang, C. Y., Jun 1 2017, In : International Journal of Molecular Sciences. 18, 6, A1132.

Research output: Contribution to journalArticle

21 Citations (Scopus)

β-Catenin overexpression causes an increase in inflammatory cytokines and NF-kB activation in cardiomyocytes

Lin, J. C., Chang, R. L., Chen, Y. F., Yang, J. J., Baskaran, R., Chung, L. C., Chen, R. J., Day, C. H., Vijaya Padma, V. & Huang, C. Y., 2017, In : Cellular and Molecular Biology. 63, 1, p. 17-22 6 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018

Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats

Chen, W. K., Tsai, Y. L., Shibu, M. A., Shen, C. Y., Chang-Lee, S. N., Chen, R. J., Yao, C. H., Ban, B., Kuo, W. W. & Huang, C. Y., Dec 1 2018, In : Aging. 10, 12, p. 4166-4174 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2017

Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration

Chang, Y. M., Chang, H. H., Tsai, C. C., Lin, H. J., Ho, T. J., Ye, C. X., Chiu, P. L., Chen, Y. S., Chen, R. J., Huang, C. Y. & Lin, C. C., Mar 31 2017, In : BMC Complementary and Alternative Medicine. 17, 1, 184.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2018

C-terminus of Hsc70-interacting protein (CHIP) enhances stemness properties of human Wharton’s jelly mesenchymal stem cell

Yang, C. K., Feng, C. C., Lo, J. F., Chen, J. W., Padma, V. V., Lai, C. H., Chen, T. S., Chen, R. J., Liao, P. H. & Huang, C. Y., Nov 17 2018, In : Biotechnic and Histochemistry. 93, 8, p. 632-639 8 p.

Research output: Contribution to journalArticle

Epithelioid Angiomyolipoma of the Liver

Huang, Y. M., Wei, P. L. & Chen, R. J., Jan 1 2018, In : Journal of Gastrointestinal Surgery. 22, 1, p. 175-176 2 p.

Research output: Contribution to journalArticle

2017

Interleukin 15 activates Akt to protect astrocytes from oxygen glucose deprivation-induced cell death

Lee, G. A., Lai, Y. G., Chen, R. J. & Liao, N. S., Apr 1 2017, In : Cytokine. 92, p. 68-74 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets

Lu, W. J., Chung, C. L., Chen, R. J., Huang, L. T., Lien, L. M., Chang, C. C., Lin, K. H. & Sheu, J. R., Nov 14 2018, In : Journal of Clinical Medicine. 7, 11

Research output: Contribution to journalArticle

2019

Insulin-like growth factor II receptor-α is a novel stress-inducible contributor to cardiac damage underpinning doxorubicin-induced oxidative stress and perturbed mitochondrial autophagy

Pandey, S., Kuo, W. W., Shen, C. Y., Yeh, Y. L., Ho, T. J., Chen, R. J., Chang, R. L., Pai, P. Y., Viswanadha, V. P., Huang, C. Y. & Huang, C. Y., Aug 2019, In : American Journal of Physiology - Cell Physiology. 317, 2, p. C235-C243

Research output: Contribution to journalArticle

4 Citations (Scopus)

Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats

Chen, Y. P., Sivalingam, K., Shibu, M. A., Peramaiyan, R., Day, C. H., Shen, C. Y., Lai, C. H., Chen, R. J., Viswanadha, V. P., Chen, Y. F. & Huang, C. Y., Apr 1 2019, In : Phytomedicine. 57, p. 1-8 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2018

Alpinate Oxyphyllae extracts enhance the longevity and homing of mesenchymal stem cells and augment their protection against senescence in H9c2 cells

Chang, Y. M., Asokan Shibu, M., Tsai, C. T., Tsai, C. C., Lin, S. L., Chang, C. C., Viswanadha, V. P., Chen, R. J., Chang, J. H. M. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation

Chao, C. N., Lai, C. H., Badrealam, K. F., Lo, J. F., Shen, C. Y., Chen, C. H., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Nov 1 2019, In : Journal of Cellular Physiology. 234, 11, p. 20128-20138 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Corrigendum to "Early changes of the anemia phenomenon in male 100-km ultramarathoners" [J Chin Med Assoc, 78, (2015), 108-113] Doi: 10.1016/j.jcma.2014.09.004

Chiu, Y. H., Lai, J. I., Wang, S. H., How, C. K., Li, L. H., Kao, W. F., Yang, C. C. & Chen, R. J., Feb 1 2016, In : Journal of the Chinese Medical Association. 79, 2, p. 101 1 p.

Research output: Contribution to journalArticle

2019

Tid1-S attenuates LPS-induced cardiac hypertrophy and apoptosis through ER-a mediated modulation of p-PI3K/p-Akt signaling cascade

Chao, C. N., Lo, J. F., Khan, F. B., Day, C. H., Lai, C. H., Chen, C. H., Chen, R. J., Viswanadha, V. P., Kuo, C. H. & Huang, C. Y., Jan 1 2019, In : Journal of Cellular Biochemistry. 120, 10, p. 16703-16710 8 p.

Research output: Contribution to journalArticle

2017
4 Citations (Scopus)
2018
9 Citations (Scopus)
2019

Synergistic cardiac pathological hypertrophy induced by high-salt diet in IGF-IIRα cardiac-specific transgenic rats

Chang, R. L., Nithiyanantham, S., Huang, C. Y., Pai, P. Y., Chang, T. T., Hu, L. C., Chen, R. J., VijayaPadma, V., Kuo, W. W. & Huang, C. Y., Jun 1 2019, In : PLoS ONE. 14, 6, e0216285.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2016
31 Citations (Scopus)

GABA tea attenuates cardiac apoptosis in spontaneously hypertensive rats (SHR) by enhancing PI3K/Akt-mediated survival pathway and suppressing Bax/Bak dependent apoptotic pathway

Chen, B. C., Hung, M. Y., Wang, H. F., Yeh, L. J., Pandey, S., Chen, R. J., Chang, R. L., Viswanadha, V. P., Lin, K. H. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Overexpression of IGF-IIRα regulates cardiac remodeling and aggravates high salt induced apoptosis and fibrosis in transgenic rats

Chang, R. L., Nithiyanantham, S., Kuo, W. W., Pai, P. Y., Chang, T. T., Lai, C. H., Chen, R. J., Vijaya Padma, V., Huang, C. Y. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2016

Taiwanin E inhibits cell migration in human LoVo colon cancer cells by suppressing MMP-2/9 expression via p38 MAPK pathway

Hsu, H. H., Kuo, W. W., Day, C. H., Shibu, M. A., Li, S. Y., Chang, S. H., Shih, H. N., Chen, R. J., Viswanadha, V. P., Kuo, Y. H. & Huang, C. Y., 2016, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2017

Trends in diagnostic approaches for pediatric appendicitis: Nationwide population-based study

Luo, C. C., Chien, W. K., Huang, C. S., Lo, H. C., Wu, S. M., Huang, H. C., Chen, R. J. & Chao, H. C., Nov 3 2017, In : BMC Pediatrics. 17, 1, 188.

Research output: Contribution to journalArticle

2016
8 Citations (Scopus)

Nobiletin, a Polymethoxylated Flavone, Inhibits Glioma Cell Growth and Migration via Arresting Cell Cycle and Suppressing MAPK and Akt Pathways

Lien, L. M., Wang, M. J., Chen, R. J., Chiu, H. C., Wu, J. L., Shen, M. Y., Chou, D. S., Sheu, J. R., Lin, K. H. & Lu, W-J., Feb 1 2016, In : Phytotherapy Research. 30, 2, p. 214-221 8 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)