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  • Ray-Jade Chen
2018

Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p-JNK mediated hypertrophy and enhancing P-IGF1R, p-akt, and p-Badser136 activity and by fortifying NRF2 antioxidation system

Shibu, M. A., Kuo, C. H., Chen, B. C., Ju, D. T., Chen, R. J., Lai, C. H., Huang, P. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Feb 1 2018, In : Environmental Toxicology. 33, 2, p. 220-233

Research output: Contribution to journalArticle

14 Citations (Scopus)
2017

Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy

Chen, Y. F., Lee, N. H., Pai, P. Y., Chung, L. C., Shen, C. Y., Rajendran, P., Chen, Y. F., Chen, R. J., Padma Viswanadha, V., Kuo, W. W. & Huang, C. Y., Sep 3 2017, In : Journal of Receptors and Signal Transduction. 37, 5, p. 493-499 7 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018
9 Citations (Scopus)
2017
4 Citations (Scopus)
2020

A population-based cohort study of mortality of intensive care unit patients with liver cirrhosis

Huang, Y. F., Lin, C. S., Cherng, Y. G., Yeh, C. C., Chen, R. J., Chen, T. L. & Liao, C. C., Jan 16 2020, In : BMC Gastroenterology. 20, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
2016

Lactobacillus reuteri GMNL-263 reduces hyperlipidaemia and the heart failure process in high-calorie diet-fed induced heart dysfunction in rats

Liao, P. H., Kuo, W. W., Kuo, C. H., Yeh, Y. L., Shen, C. Y., Chen, Y. H., Chen, R. J., Padma, V. V., Chen, Y. H. & Huang, C. Y., Jan 1 2016, In : Journal of Functional Foods. 20, p. 226-235 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2018

GABA tea attenuates cardiac apoptosis in spontaneously hypertensive rats (SHR) by enhancing PI3K/Akt-mediated survival pathway and suppressing Bax/Bak dependent apoptotic pathway

Chen, B. C., Hung, M. Y., Wang, H. F., Yeh, L. J., Pandey, S., Chen, R. J., Chang, R. L., Viswanadha, V. P., Lin, K. H. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Suppression of isoproterenol-induced apoptosis in H9c2 cardiomyoblast cells by daidzein through activation of Akt

Hu, W. S., Lin, Y. M., Kuo, W. W., Pan, L. F., Yeh, Y. L., Li, Y. H., Kuo, C. H., Chen, R. J., Vijaya Padma, V., Chen, T. S. & Huang, C. Y., 2016, In : Chinese Journal of Physiology. 59, 6, p. 323-330 8 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2017

Tanshinone IIA inhibits β-catenin nuclear translocation and IGF-2R activation via estrogen receptors to suppress angiotensin II-induced H9c2 cardiomyoblast cell apoptosis

Chen, Y. F., Day, C. H., Lee, N. H., Chen, Y. F., Yang, J. J., Lin, C. H., Chen, R. J., Rajendran, P., Viswanadha, V. P. & Huang, C. Y., Sep 30 2017, In : International Journal of Medical Sciences. 14, 12, p. 1284-1291 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2019

Protective effect of Fisetin against angiotensin II-induced apoptosis by activation of IGF-IR-PI3K-Akt signaling in H9c2 cells and spontaneous hypertension rats

Chen, Y. P., Sivalingam, K., Shibu, M. A., Peramaiyan, R., Day, C. H., Shen, C. Y., Lai, C. H., Chen, R. J., Viswanadha, V. P., Chen, Y. F. & Huang, C. Y., Apr 1 2019, In : Phytomedicine. 57, p. 1-8 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2017

Interleukin 15 activates Akt to protect astrocytes from oxygen glucose deprivation-induced cell death

Lee, G. A., Lai, Y. G., Chen, R. J. & Liao, N. S., Apr 1 2017, In : Cytokine. 92, p. 68-74 7 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2016

Therapeutic effectiveness of percutaneous drainage and factors for performing an interval appendectomy in pediatric appendiceal abscess

Luo, C. C., Cheng, K. F., Huang, C. S., Lo, H-C., Wu, S. M., Huang, H. C., Chien, W. K. & Chen, R. J., Oct 18 2016, In : BMC Surgery. 16, 1, 72.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2019

CHIP attenuates lipopolysaccharide-induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation

Chao, C. N., Lai, C. H., Badrealam, K. F., Lo, J. F., Shen, C. Y., Chen, C. H., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Nov 1 2019, In : Journal of Cellular Physiology. 234, 11, p. 20128-20138 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Mechanism of Taiwan Mingjian Oolong Tea to Inhibit Isoproterenol-Induced Hypertrophy and Apoptosis in Cardiomyoblasts

Yeh, Y. L., Tsai, H. I., Cheng, S. M., Pai, P., Ho, T. J., Chen, R. J., Lai, C. H., Huang, P. J., Padma, V. V. & Huang, C. Y., Feb 1 2016, In : American Journal of Chinese Medicine. 44, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2018

Acute hypoxic preconditioning prevents palmitic acid-induced cardiomyocyte apoptosis via switching metabolic GLUT4-glucose pathway back to CD36-fatty acid dependent

Chen, Y. P., Kuo, W. W., Baskaran, R., Day, C. H., Chen, R. J., Wen, S. Y., Ho, T. J., Padma, V. V., Kuo, C. H. & Huang, C. Y., Apr 1 2018, In : Journal of Cellular Biochemistry. 119, 4, p. 3363-3372 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Data supporting the angiotensin II activates MEL18 to deSUMOylate HSF2 for hypertension-related heart failure

Huang, C. Y., Kuo, C. H., Pai, P. Y., Ho, T. J., Lin, Y. M., Chen, R. J., Tsai, F. J., Vijaya Padma, V., Kuo, W. W. & Huang, C. Y., Feb 1 2018, In : Data in Brief. 16, p. 521-526 6 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Overexpression of IGF-IIRα regulates cardiac remodeling and aggravates high salt induced apoptosis and fibrosis in transgenic rats

Chang, R. L., Nithiyanantham, S., Kuo, W. W., Pai, P. Y., Chang, T. T., Lai, C. H., Chen, R. J., Vijaya Padma, V., Huang, C. Y. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The preventive effects of edible folic acid on cardiomyocyte apoptosis and survival in early onset triple-transgenic Alzheimer's disease model mice

Lin, K. H., Chiu, C. H., Kuo, W. W., Ju, D. T., Shen, C. Y., Chen, R. J., Lin, C. C., Viswanadha, V. P., Liu, J. S., Huang, R. F. S. & Huang, C. Y., Jan 2018, In : Environmental Toxicology. 33, 1, p. 83-92

Research output: Contribution to journalArticle

6 Citations (Scopus)

Fenofibrate induced PPAR alpha expression was attenuated by oestrogen receptor alpha overexpression in Hep3B cells

Jeng, L. B., Velmurugan, B. K., Hsu, H. H., Wen, S. Y., Shen, C. Y., Lin, C. H., Lin, Y. M., Chen, R. J., Kuo, W. W. & Huang, C. Y., Feb 1 2018, In : Environmental Toxicology. 33, 2, p. 234-247 14 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Developing a scalable, cross-facility-based therapeutic decision reminder engine

Yang, C. Y., Tsai, M. C., Chen, R. J., Lo, Y. S., Kang, L. Y. & Liu, C. T., 2016, WCECS 2016 - World Congress on Engineering and Computer Science 2016. Newswood Limited, Vol. 2225. p. 201-207 7 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2017

High density lipoprotein (HDL) reverses palmitic acid induced energy metabolism imbalance by switching CD36 and GLUT4 signaling pathways in cardiomyocyte

Wen, S. Y., Velmurugan, B. K., Day, C. H., Shen, C. Y., Chun, L. C., Tsai, Y. C., Lin, Y. M., Chen, R. J., Kuo, C. H. & Huang, C. Y., 2017, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

3 Citations (Scopus)
2019

Tid1-S attenuates LPS-induced cardiac hypertrophy and apoptosis through ER-a mediated modulation of p-PI3K/p-Akt signaling cascade

Chao, C. N., Lo, J. F., Khan, F. B., Day, C. H., Lai, C. H., Chen, C. H., Chen, R. J., Viswanadha, V. P., Kuo, C. H. & Huang, C. Y., Jan 1 2019, In : Journal of Cellular Biochemistry. 120, 10, p. 16703-16710 8 p.

Research output: Contribution to journalArticle

2018

Lupeol alters ER stress-signaling pathway by downregulating ABCG2 expression to induce Oxaliplatin-resistant LoVo colorectal cancer cell apoptosis

Chen, M. C., Hsu, H. H., Chu, Y. Y., Cheng, S. F., Shen, C. Y., Lin, Y. J., Chen, R. J., Viswanadha, V. P., Lin, Y. M. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2017

How motorcycle helmets affect trauma mortality: Clinical and policy implications

Lee, J. L., Chen, T. C., Huang, H. C. & Chen, R. J., Aug 18 2017, In : Traffic Injury Prevention. 18, 6, p. 666-671 6 p.

Research output: Contribution to journalArticle

Enhancement of beta-catenin in cardiomyocytes suppresses survival protein expression but promotes apoptosis and fibrosis

Lin, J. C., Kuo, W. W., Baskaran, R., Chen, M. C., Ho, T. J., Chen, R. J., Chen, Y. F., Padma, V. V., Lay, I. S. & Huang, C. Y., 2017, In : Cardiology Journal. 24, 2, p. 195-205 11 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2019

Upregulation of IGF-IIRα intensifies doxorubicin-induced cardiac damage

Pandey, S., Kuo, W. W., Ho, T. J., Yeh, Y. L., Shen, C. Y., Chen, R. J., Chang, R. L., Pai, P. Y., Padma, V. V., Huang, C. Y. & Huang, C. Y., Jan 1 2019, In : Journal of Cellular Biochemistry. 120, 10, p. 16956-16966 11 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Blockchain-enabled iWellChain framework integration with the national medical referral system: Development and usability study

Lo, Y. S., Yang, C. Y., Chien, H. F., Chang, S. S., Lu, C. Y. & Chen, R. J., Jan 1 2019, In : Journal of Medical Internet Research. 21, 12, e13563.

Research output: Contribution to journalArticle

Open Access

Insulin-like growth factor II receptor-α is a novel stress-inducible contributor to cardiac damage underpinning doxorubicin-induced oxidative stress and perturbed mitochondrial autophagy

Pandey, S., Kuo, W. W., Shen, C. Y., Yeh, Y. L., Ho, T. J., Chen, R. J., Chang, R. L., Pai, P. Y., Viswanadha, V. P., Huang, C. Y. & Huang, C. Y., Aug 2019, In : American Journal of Physiology - Cell Physiology. 317, 2, p. C235-C243

Research output: Contribution to journalArticle

3 Citations (Scopus)
2018

Lipoteichoic acid upregulates plasminogen activator inhibitor-1 expression in parapneumonic effusions

Lee, K. L., Chen, W. L., Chen, R. J., Lai, K. S. & Chung, C. L., Jan 1 2018, In : Respirology. 23, 1, p. 89-95 7 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

C-terminus of Hsc70-interacting protein (CHIP) enhances stemness properties of human Wharton’s jelly mesenchymal stem cell

Yang, C. K., Feng, C. C., Lo, J. F., Chen, J. W., Padma, V. V., Lai, C. H., Chen, T. S., Chen, R. J., Liao, P. H. & Huang, C. Y., Nov 17 2018, In : Biotechnic and Histochemistry. 93, 8, p. 632-639 8 p.

Research output: Contribution to journalArticle

2017

Development of benzimidazole derivatives as novel anti-platelet drugs

Yao, W. C., Yuan, L. T., Yang, W. B., Hsia, C. H., Huang, L. T., Lee, T. Y., Sheu, J. R., Lu, W-J., Jayakumar, T. & Chen, R. J., Jan 1 2017, In : Current Pharmaceutical Biotechnology. 18, 7, p. 594-605 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2019

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., Mar 1 2019, In : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

Research output: Contribution to journalArticle

VAS2870 and VAS3947 attenuate platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC

Lu, W. J., Li, J. Y., Chen, R. J., Huang, L. T., Lee, T. Y. & Lin, K. H., Dec 1 2019, In : Scientific Reports. 9, 1, 18852.

Research output: Contribution to journalArticle

Open Access
2017
4 Citations (Scopus)
2017

Identification of epidermal growth factor receptor-positive glioblastoma using lipid-encapsulated targeted superparamagnetic iron oxide nanoparticles in vitro

Chen, H. L., Hsu, F. T., Kao, Y. C. J., Liu, H. S., Huang, W. Z., Lu, C. F., Tsai, P. H., Ali, A. A. A., Lee, G. A., Chen, R. J. & Chen, C. Y., Nov 22 2017, In : Journal of Nanobiotechnology. 15, 1, 86.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2019

Embelin as a Novel Inhibitor of PKC in the Prevention of Platelet Activation and Thrombus Formation

Li, J. Y., Chen, R. J., Huang, L. T., Lee, T. Y., Lu, W. J. & Lin, K. H., Oct 18 2019, In : Journal of Clinical Medicine. 8, 10

Research output: Contribution to journalArticle

2017

Major pancreatic duct continuity is the crucial determinant in the management of blunt pancreatic injury: a pancreatographic classification

Lin, B. C., Wong, Y-C., Chen, R. J., Liu, N. J., Wu, C. H., Hwang, T. L. & Hsu, Y. P., Mar 9 2017, (Accepted/In press) In : Surgical Endoscopy and Other Interventional Techniques. p. 1-10 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2016

Taiwanin E inhibits cell migration in human LoVo colon cancer cells by suppressing MMP-2/9 expression via p38 MAPK pathway

Hsu, H. H., Kuo, W. W., Day, C. H., Shibu, M. A., Li, S. Y., Chang, S. H., Shih, H. N., Chen, R. J., Viswanadha, V. P., Kuo, Y. H. & Huang, C. Y., 2016, (Accepted/In press) In : Environmental Toxicology.

Research output: Contribution to journalArticle

11 Citations (Scopus)
2017

Prostaglandin E2-induced COX-2 expressions via EP2 and EP4 signaling pathways in human LoVo colon cancer cells

Hsu, H. H., Lin, Y. M., Shen, C. Y., Shibu, M. A., Li, S. Y., Chang, S. H., Lin, C. C., Chen, R. J., Viswanadha, V. P., Shih, H. N. & Huang, C. Y., Jun 1 2017, In : International Journal of Molecular Sciences. 18, 6, A1132.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2016

Palmitic acid interferes with energy metabolism balance by adversely switching the SIRT1-CD36-fatty acid pathway to the PKC-GLUT4-glucose pathway in cardiomyoblasts

Chen, Y. P., Tsai, C. W., Shen, C. Y., Day, C. H., Yeh, Y. L., Chen, R. J., Ho, T. J., Padma, V. V., Kuo, W. W. & Huang, C. Y., May 1 2016, In : Journal of Nutritional Biochemistry. 31, p. 137-149 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2018

Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy

Huang, C. Y., Kuo, C. H., Pai, P. Y., Ho, T. J., Lin, Y. M., Chen, R. J., Tsai, F. J., Vijaya Padma, V., Kuo, W. W. & Huang, C. Y., Apr 15 2018, In : International Journal of Cardiology. 257, p. 283-290

Research output: Contribution to journalArticle

10 Citations (Scopus)
2019

Synergistic cardiac pathological hypertrophy induced by high-salt diet in IGF-IIRα cardiac-specific transgenic rats

Chang, R. L., Nithiyanantham, S., Huang, C. Y., Pai, P. Y., Chang, T. T., Hu, L. C., Chen, R. J., VijayaPadma, V., Kuo, W. W. & Huang, C. Y., Jun 1 2019, In : PLoS ONE. 14, 6, e0216285.

Research output: Contribution to journalArticle

Open Access
2017

Elevated Phosphate Levels Trigger Autophagy-Mediated Cellular Apoptosis in H9c2 Cardiomyoblasts

Liu, Y. L., Lin, K. H., Tamilselvi, S., Chen, W. K., Shen, C. Y., Chen, R. J., Day, C. H., Wu, H. C., Viswanadha, V. P. & Huang, C. Y., Sep 30 2017, (Accepted/In press) In : CardioRenal Medicine. p. 31-40 10 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2018

Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts

Feng, C. C., Pandey, S., Lin, C. Y., Shen, C. Y., Chang, R. L., Chang, T. T., Chen, R. J., Viswanadha, V. P., Lin, Y. M. & Huang, C. Y., Jan 1 2018, In : Biomedicine and Pharmacotherapy. 97, p. 880-885 6 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)
2016

Anti-apoptotic and pro-survival effect of alpinate oxyphyllae fructus (AOF) in a D-galactose-induced aging heart

Chang, Y. M., Chang, H. H., Kuo, W. W., Lin, H. J., Yeh, Y. L., Viswanadha, V. P., Tsai, C. C., Chen, R. J., Chang, H. N. & Huang, C. Y., Mar 29 2016, In : International Journal of Molecular Sciences. 17, 4, 466.

Research output: Contribution to journalArticle

19 Citations (Scopus)
2018

E4BP4 inhibits AngII-induced apoptosis in H9c2 cardiomyoblasts by activating the PI3K-Akt pathway and promoting calcium uptake

Chen, B. C., Shibu, M. A., Kuo, C. H., Shen, C. Y., Chang-Lee, S. N., Lai, C. H., Chen, R. J., Yao, C. H., Viswanadha, V. P., Liu, J. S., Chen, W. K. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Experimental Cell Research.

Research output: Contribution to journalArticle

3 Citations (Scopus)

The multifaceted link between inflammation and human diseases

Rajendran, P., Chen, Y. F., Chen, Y. F., Chung, L. C., Tamilselvi, S., Shen, C. Y., Day, C. H., Chen, R. J., Viswanadha, V. P., Kuo, W. W. & Huang, C. Y., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2019

Lessons learned from isolated blunt major pancreatic injury: Surgical experience in one trauma centre

Lin, B. C., Chen, R. J. & Hwang, T. L., Jan 1 2019, In : Injury.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2016

Corrigendum to "Early changes of the anemia phenomenon in male 100-km ultramarathoners" [J Chin Med Assoc, 78, (2015), 108-113] Doi: 10.1016/j.jcma.2014.09.004

Chiu, Y. H., Lai, J. I., Wang, S. H., How, C. K., Li, L. H., Kao, W. F., Yang, C. C. & Chen, R. J., Feb 1 2016, In : Journal of the Chinese Medical Association. 79, 2, p. 101 1 p.

Research output: Contribution to journalArticle