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  • Yun Yen
2016

Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells

Chen, Y. R., Tsou, B., Hu, S., Ma, H., Liu, X., Yen, Y. & Ann, D. K., Jan 1 2016, In : Oncotarget. 7, 2, p. 1984-1999 16 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

Precision Medicine and Pancreatic Cancer

Farrell, J. J., Moughan, J., Wong, J. L., Regine, W. F., Schaefer, P., Benson, A. B., Macdonald, J. S., Liu, X., Yen, Y., Lai, R., Zheng, Z., Bepler, G., Guha, C. & Elsaleh, H., Nov 1 2016, In : Pancreas. 45, 10, p. 1485-1493 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2019

Novel Common Genetic Susceptibility Loci for Colorectal Cancer

Schmit, S. L., Edlund, C. K., Schumacher, F. R., Gong, J., Harrison, T. A., Huyghe, J. R., Qu, C., Melas, M., Van Den Berg, D. J., Wang, H., Tring, S., Plummer, S. J., Albanes, D., Alonso, M. H., Amos, C. I., Anton, K., Aragaki, A. K., Arndt, V., Barry, E. L., Berndt, S. I. & 30 others, Bezieau, S., Bien, S., Bloomer, A., Boehm, J., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buchanan, D. D., Butterbach, K., Caan, B. J., Campbell, P. T., Carlson, C. S., Castelao, J. E., Chan, A. T., Chang-Claude, J., Chanock, S. J., Cheng, I., Cheng, Y. W., Chin, L. S., Church, J. M., Church, T., Coetzee, G. A., Cotterchio, M., Cruz Correa, M., Curtis, K. R., Duggan, D., Lin, Y., Liu, Y. R., Yen, Y. & Hsu, L., Feb 1 2019, In : Journal of the National Cancer Institute. 111, 2, p. 146-157 12 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2018

Tyrosine kinase inhibitors for advanced or metastatic thyroid cancer: a meta-analysis of randomized controlled trials

Liu, J. W., Chen, C., Loh, E. W., Chu, C. C., Wang, M. Y., Ouyang, H. J., Chang, Y. T., Zhuang, W. Z., Chou, C. W., Huang, D. J., Lee, C. H., Yen, Y. & Tam, K. W., 2018, In : Current Medical Research and Opinion. p. 1-9 9 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Global DNA methylation analysis reveals miR-214-3p contributes to cisplatin resistance in pediatric intracranial nongerminomatous malignant germ cell tumors

Hsieh, T. H., Liu, Y. R., Chang, T. Y., Liang, M. L., Chen, H. H., Wang, H. W., Yen, Y. & Wong, T-T., Mar 27 2018, In : Neuro-Oncology. 20, 4, p. 519-530 12 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2020

Astragalus membranaceus-Derived Anti-Programmed Death-1 Monoclonal Antibodies with Immunomodulatory Therapeutic Effects against Tumors

Chang, F. L., Tsai, K. C., Lin, T. Y., Yang, T. W., Lo, Y. N., Chen, W. C., Chang, J. H., Lu, M. K., Chiou, C. T., Chen, P. H., Yen, Y., Pan, S. L. & Lee, Y. C., Jan 1 2020, In : BioMed Research International. 2020, 3415471.

Research output: Contribution to journalArticle

Open Access
2016

Observation of polarization and thickness dependent third-harmonic generation in multilayer black phosphorus

Wu, H. Y., Yen, Y. & Liu, C. H., Dec 26 2016, In : Applied Physics Letters. 109, 26, 261902.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Proton pump inhibitors and risk of periampullary cancers - A nested case-control study

Chien, L-N., Huang, Y. J., Shao, Y-H., Chang, C. J., Chuang, M. T., Chiou, H-Y. & Yen, Y., Mar 15 2016, In : International Journal of Cancer. 138, 6, p. 1401-1409 9 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)
2019

Cancers in Taiwan: Practical insight from epidemiology, treatments, biomarkers, and cost

Kuo, C. N., Liao, Y. M., Kuo, L. N., Tsai, H. J., Chang, W. C. & Yen, Y., Jan 1 2019, (Accepted/In press) In : Journal of the Formosan Medical Association.

Research output: Contribution to journalReview article

Open Access
3 Citations (Scopus)
2017

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Huang, Y. J., Yang, C. K., Wei, P. L., Huynh, T. T., Whang-Peng, J., Meng, T. C., Hsiao, M., Tzeng, Y. M., Wu, A. T. & Yen, Y., Feb 28 2017, In : Journal of hematology & oncology. 10, 1, p. 60 1 p.

Research output: Contribution to journalArticle

24 Citations (Scopus)
2016

Prognostic and therapeutic value of mitochondrial serine hydroxyl-methyltransferase 2 as a breast cancer biomarker

Zhang, L., Chen, Z., Xue, D., Zhang, Q., Liu, X., Luh, F., Hong, L., Zhang, H., Pan, F., Liu, Y., Chu, P., Zheng, S., Lou, G. & Yen, Y., Nov 1 2016, In : Oncology Reports. 36, 5, p. 2489-2500 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)
2017

Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers

Ding, J., Kuo, M. L., Su, L., Xue, L., Luh, F., Zhang, H., Wang, J., Lin, T. G., Zhang, K., Chu, P., Zheng, S., Liu, X. & Yen, Y., May 1 2017, In : Carcinogenesis. 38, 5, p. 519-531 13 p., bgx022.

Research output: Contribution to journalArticle

28 Citations (Scopus)

Overexpression of uridine-cytidine kinase 2 correlates with breast cancer progression and poor prognosis

Shen, G., He, P., Mao, Y., Li, P., Luh, F., Ding, G., Liu, X. & Yen, Y., Jun 1 2017, In : Journal of Breast Cancer. 20, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2019

Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer

Lu, H., Wang, C., Xue, L., Zhang, Q., Luh, F., Wang, J., Lin, T. G., Yen, Y. & Liu, X., Jan 1 2019, In : Journal of Oncology. 2019, 2316237.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2018

Machine learning–based radiomics for molecular subtyping of gliomas

Lu, C-F., Hsu, F-T., Hsieh, KL-C., Kao, Y-CJ., Cheng, S-J., Hsu, JB-K., Tsai, P-H., Chen, R-J., Huang, C-C., Yen, Y. & Chen, C-Y., Sep 15 2018, In : Clinical Cancer Research. 24, 18, p. 4429-4436 8 p.

Research output: Contribution to journalArticle

43 Citations (Scopus)
2016

Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation

Chang, L. C., Chen, T. C., Chen, S. J., Chen, C. L., Lee, C. C., Wu, S. H., Yen, Y., Huang, H. S. & Lin, J. J., Oct 18 2016, In : Oncotarget. 7, 42, p. 67986-68001 16 p.

Research output: Contribution to journalArticle

CRLX101 nanoparticles localize in human tumors and not in adjacent, nonneoplastic tissue after intravenous dosing

Clark, A. J., Wiley, D. T., Zuckerman, J. E., Webster, P., Chao, J., Lin, J., Yen, Y. & Davis, M. E., Apr 5 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 14, p. 3850-3854 5 p.

Research output: Contribution to journalArticle

86 Citations (Scopus)
2017
7 Citations (Scopus)
2019

Design and Evaluation of PEGylated Liposomal Formulation of a Novel Multikinase Inhibitor for Enhanced Chemosensitivity and Inhibition of Metastatic Pancreatic Ductal Adenocarcinoma

Madamsetty, V. S., Pal, K., Dutta, S. K., Wang, E., Thompson, J. R., Banerjee, R. K., Caulfield, T. R., Mody, K., Yen, Y., Mukhopadhyay, D. & Huang, H-S., Oct 4 2019, In : Bioconjugate Chemistry.

Research output: Contribution to journalArticle

1 Citation (Scopus)
2018

A phase I trial of escalating doses of cixutumumab (IMC-A12) and sorafenib in the treatment of advanced hepatocellular carcinoma

El-Khoueiry, A. B., O’Donnell, R., Semrad, T. J., Mack, P., Blanchard, S., Bahary, N., Jiang, Y., Yen, Y., Wright, J., Chen, H., Lenz, H. J. & Gandara, D. R., May 1 2018, In : Cancer Chemotherapy and Pharmacology. 81, 5, p. 957-963 7 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2016

Chemotherapy for advanced biliary tract carcinoma: A meta-analysis of randomized controlled trials

Chen, L., Chen, C., Yen, Y. & Tam, K. W., Aug 1 2016, In : Medicine (United States). 95, 33, 385.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2018

Differences in silencing of mismatched targets by sliced versus diced siRNAs

Sun, G., Wang, J., Huang, Y., Yuan, C. W. Y., Zhang, K., Hu, S., Chen, L., Lin, R. J., Yen, Y. & Riggs, A. D., Jan 1 2018, In : Nucleic Acids Research. 46, 13, p. 6806-6822 17 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer

Luu, T., Kim, K. P., Blanchard, S., Anyang, B., Hurria, A., Yang, L., Beumer, J. H., Somlo, G. & Yen, Y., Jan 1 2018, In : Breast Cancer Research and Treatment. 167, 2, p. 469-478 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2019
Open Access

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2

Chen, H. Y., Lang, Y. D., Lin, H. N., Liu, Y. R., Liao, C. C., Nana, A. W., Yen, Y. & Chen, R. H., Dec 1 2019, In : Scientific Reports. 9, 1, 9687.

Research output: Contribution to journalArticle

Open Access
5 Citations (Scopus)
2018

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Cheng, C. T., Qi, Y., Wang, Y. C., Chi, K. K., Chung, Y., Ouyang, C., Chen, Y. R., Oh, M. E., Sheng, X., Tang, Y., Liu, Y. R., Lin, H. H., Kuo, C. Y., Schones, D., Vidal, C. M., Chu, J. C. Y., Wang, H. J., Chen, Y. H., Miller, K. M., Chu, P. & 4 others, Yen, Y., Jiang, L., Kung, H. J. & Ann, D. K., Dec 1 2018, In : Communications Biology. 1, 1, 178.

Research output: Contribution to journalArticle

Open Access
9 Citations (Scopus)

The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes

Wang, Y. C., Chang, K. C., Lin, B. W., Lee, J. C., Lai, C. H., Lin, L. J., Yen, Y., Lin, C. S., Yang, S. J., Lin, P. C., Lee, C. T. & Hung, L. Y., Jun 1 2018, In : Experimental and Molecular Medicine. 50, 6, p. 70 70.

Research output: Contribution to journalArticle

2 Citations (Scopus)
2017

Pilot trial of CRLX101 in patients with advanced, chemotherapyrefractory gastroesophageal cancer

Chao, J., Lin, J., Frankel, P., Clark, A. J., Wiley, D. T., Garmey, E., Fakih, M., Lim, D., Chung, V., Luevanos, E., Eliasof, S., Davis, M. E. & Yen, Y., Dec 1 2017, In : Journal of Gastrointestinal Oncology. 8, 6, p. 962-969 8 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2018

Application of bioconjugation chemistry on biosensor fabrication for detection of TAR-DNA binding protein 43

Dai, Y., Wang, C., Chiu, L. Y., Abbasi, K., Tolbert, B. S., Sauvé, G., Yen, Y. & Liu, C. C., Oct 15 2018, In : Biosensors and Bioelectronics. 117, p. 60-67 8 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2020

Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors

Tran, H. M., Wu, K. S., Sung, S. Y., Changou, C. A., Hsieh, T. H., Liu, Y. R., Liu, Y. L., Tsai, M. L., Lee, H. L., Hsieh, K. L. C., Huang, W. C., Liang, M. L., Chen, H. H., Lee, Y. Y., Lin, S. C., Ho, D. M. T., Chang, F. C., Chao, M. E., Chen, W., Chu, S. S. & 4 others, Yu, A. L., Yen, Y., Chang, C. C. & Wong, T. T., Mar 22 2020, In : Cancers. 12, 3, 752.

Research output: Contribution to journalArticle

Open Access
2016

Novel regulators and molecular mechanisms of p53R2 and its disease relevance

Cho, E. C. & Yen, Y., Apr 1 2016, In : Biochimie. 123, p. 81-84 4 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress

Kuo, M. L., Lee, M. B. E., Tang, M., Den Besten, W., Hu, S., Sweredoski, M. J., Hess, S., Chou, C. M., Changou, C. A., Su, M., Jia, W., Su, L. & Yen, Y., Jan 6 2016, In : Scientific Reports. 6, 18846.

Research output: Contribution to journalArticle

25 Citations (Scopus)
11 Citations (Scopus)
2019

The Ambivalent Role of lncRNA Xist in Carcinogenesis

Chen, Y. K. & Yen, Y., Apr 15 2019, In : Stem Cell Reviews and Reports. 15, 2, p. 314-323 10 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., Oct 1 2019, In : Medicine (United States). 98, 40, p. e17461 e17461.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)
2017

Does aspirin use reduce the risk for cancer?

Usman, I., Yang, H. C., Jian, W. S., Yen, Y. & Li, Y. C., Feb 1 2017, In : Journal of Investigative Medicine. 65, 2, p. 391-392 2 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Shih, J. W., Chiang, W. F., Wu, A. T. H., Wu, M. H., Wang, L. Y., Yu, Y. L., Hung, Y. W., Wang, W. C., Chu, C. Y., Hung, C. L., Changou, C. A., Yen, Y. & Kung, H. J., Jun 22 2017, In : Nature Communications. 8, 15874.

Research output: Contribution to journalArticle

60 Citations (Scopus)
2019

Host immune response to anti-cancer camptothecin conjugated cyclodextrin-based polymers

Chen, Y. F., Wang, Y. H., Lei, C. S., Changou, C. A., Davis, M. E. & Yen, Y., Oct 23 2019, In : Journal of Biomedical Science. 26, 1, 1 p., 85.

Research output: Contribution to journalReview article

Open Access
1 Citation (Scopus)
2016

Research of StemBios cell therapy on dental implants containing nanostructured surfaces: Biomechanical behaviors, microstructural characteristics, and clinical trial

Ou, K. L., Weng, C. C., Wu, C. C., Lin, Y. H., Chiang, H. J., Yang, T. S., Wang, J., Yen, Y., Cheng, H. Y. & Sugiatno, E., Feb 1 2016, In : Implant Dentistry. 25, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Pu-erh Tea Extract Attenuates Nicotine-Induced Foam Cell Formation in Primary Cultured Monocytes: An in Vitro Mechanistic Study

Tu, S. H., Chen, M. Y., Chen, L. C., Mao, Y. T., Ho, C. H., Lee, W. J., Lin, Y-K., Pan, M. H., Lo, C. Y., Chen, C. L., Yen, Y., Whang-Peng, J., Ho, C. T., Wu, C. H. & Ho, Y. S., Apr 27 2016, In : Journal of Agricultural and Food Chemistry. 64, 16, p. 3186-3195 10 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)
2018

Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer

Xue, L., Liu, X., Wang, Q., Liu, C. Q., Chen, Y., Jia, W., Hsie, R., Chen, Y., Luh, F., Zheng, S. & Yen, Y., Jan 1 2018, In : American Journal of Translational Research. 10, 11, p. 3635-3649 15 p., AJTR0084684.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Web-based platform vs genetic counselors in educating patients about carrier results from exome sequencing

Yen, Y. & Luh, F., Jul 1 2018, In : JAMA Internal Medicine. 178, 7, p. 998-999 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)
2016

Integrin β3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma

Yang, S. H., Lin, H. Y., Changou, C. A., Chen, C. H., Liu, Y. R., Wang, J., Jiang, X., Luh, F. & Yen, Y., Jan 1 2016, In : Oncotarget. 7, 1, p. 362-373 12 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
2018

FDA guidance for next generation sequencing-based testing: balancing regulation and innovation in precision medicine

Luh, F. & Yen, Y., Dec 1 2018, In : npj Genomic Medicine. 3, 1, 28.

Research output: Contribution to journalComment/debate

7 Citations (Scopus)

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., Jan 1 2018, (Accepted/In press) In : European Journal of Medical Genetics.

Research output: Contribution to journalArticle

2016

Polymeric nanoparticles and cancer: Lessons learnt from CRLX101

Gritli, I., Garmey, E., Eliasof, S., Tellez, A., Davis, M. E. & Yun, Y., 2016, Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation. 51 ed. Royal Society of Chemistry, Vol. 2016-January. p. 199-232 34 p. (RSC Drug Discovery Series; vol. 2016-January, no. 51).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)
2019

DHS (trans−4,4′-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2)

Chen, C. W., Li, Y., Hu, S., Zhou, W., Meng, Y., Li, Z., Zhang, Y., Sun, J., Bo, Z., DePamphilis, M. L., Yen, Y., Han, Z. & Zhu, W., Mar 2019, In : Oncogene.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2016

Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer

Wu, J., Zhang, S., Shan, J., Hu, Z., Liu, X., Chen, L., Ren, X., Yao, L., Sheng, H., Li, L., Ann, D., Yen, Y., Wang, J. & Wang, X., Jul 1 2016, In : Cancer Letters. 376, 2, p. 284-292 9 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)
2020

Long-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats

Yang, Y. C. S. H., Chang, H. W., Lin, I. H., Chien, L. N., Wu, M. J., Liu, Y. R., Chu, P. G., Xie, G., Dong, F., Jia, W., Chang, V. H. S. & Yen, Y., Dec 1 2020, In : Scientific Reports. 10, 1, 866.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2019

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)