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  • Yun Yen
2013

Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle

Eliasof, S., Lazarus, D., Peters, C. G., Case, R. I., Cole, R. O., Hwang, J., Schluep, T., Chao, J., Lin, J., Yen, Y., Han, H., Wiley, D. T., Zuckerman, J. E. & Davis, M. E., Sep 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 37, p. 15127-15132 6 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)
2016

Polymeric nanoparticles and cancer: Lessons learnt from CRLX101

Gritli, I., Garmey, E., Eliasof, S., Tellez, A., Davis, M. E. & Yun, Y., 2016, Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation. 51 ed. Royal Society of Chemistry, Vol. 2016-January. p. 199-232 34 p. (RSC Drug Discovery Series; vol. 2016-January, no. 51).

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)
2014

MiR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis

Fu, X., Meng, Z., Liang, W., Tian, Y., Wang, X., Han, W., Lou, G., Wang, X., Lou, F., Yen, Y., Yu, H., Jove, R. & Huang, W., Aug 21 2014, In : Oncogene. 33, 34, p. 4296-4306 11 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2011
1 Citation (Scopus)

A phase II study of the antisense oligonucleotide GTI-2040 plus docetaxel and prednisone as first-line treatment in castration-resistant prostate cancer

Sridhar, S. S., Canil, C. M., Chi, K. N., Hotte, S. J., Ernst, S., Wang, L., Chen, E. X., Juhasz, A., Yen, Y., Murray, P., Zwiebel, J. A. & Moore, M. J., Apr 1 2011, In : Cancer Chemotherapy and Pharmacology. 67, 4, p. 927-933 7 p.

Research output: Contribution to journalArticle

18 Citations (Scopus)
2014

Hepatobiliary cancers, version 2.2014

Benson, A. B., D'Angelica, M. I., Abrams, T. A., Are, C., Bloomston, P. M., Chang, D. T., Clary, B. M., Covey, A. M., Ensminger, W. D., Iyer, R., Kelley, R. K., Linehan, D., Malafa, M. P., Meranze, S. G., Park, J. O., Pawlik, T., Posey, J. A., Scaife, C., Schefter, T., Sigurdson, E. R. & 8 others, Tian, G. G., Vauthey, J. N., Venook, A. P., Yen, Y., Zhu, A. X., Hoffmann, K. G., McMillian, N. R. & Sundar, H., Aug 1 2014, In : JNCCN Journal of the National Comprehensive Cancer Network. 12, 8, p. 1152-1182 31 p.

Research output: Contribution to journalReview article

44 Citations (Scopus)
2012

Identification of an AAA ATPase VPS4B-dependent pathway that modulates epidermal growth factor receptor abundance and signaling during hypoxia

Lin, H. H., Li, X., Chen, J. L., Sun, X., Cooper, F. N., Chen, Y. R., Zhang, W., Chung, Y., Li, A., Cheng, C. T., Yang, L., Deng, X. T., Liu, X., Yen, Y., Johnson, D. L., Shih, H. M., Yang, A. & Ann, D. K., Mar 1 2012, In : Molecular and Cellular Biology. 32, 6, p. 1124-1138 15 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

Emerging role of autophagy during ischemia-hypoxia and reperfusion in hepatocellular carcinoma

Du, H., Yang, W., Chen, L., Shen, B., Peng, C., Li, H., Ann, D. K., Yen, Y. & Qiu, W., Jun 1 2012, In : International Journal of Oncology. 40, 6, p. 2049-2057 9 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)

ROS1 as a 'druggable' receptor tyrosine kinase: Lessons learned from inhibiting the ALK pathway

Ou, S. H. I., Tan, J., Yen, Y. & Soo, R. A., Apr 2012, In : Expert Review of Anticancer Therapy. 12, 4, p. 447-456 10 p.

Research output: Contribution to journalArticle

96 Citations (Scopus)
2015

Primary Cutaneous Anaplastic Large Cell Lymphoma With Positive ALK Expression and a Rapidly Progressive Cutaneous Nodule

Xue, D., Li, X., Ren, Y., Liu, Q., Yen, Y. & Xue, L., Jun 3 2015, In : International Journal of Surgical Pathology. 23, 4, p. 333-335 3 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Correction: HP1β is a biomarker for breast cancer prognosis and PARP inhibitor therapy(PLoS ONE (2015) 10:3 (e0121207) 10.1371/journal.pone.0121207)

Lee, Y. H., Liu, X., Qiu, F., O'Connor, T. R., Yen, Y. & Ann, D. K., Apr 13 2015, In : PLoS One. 10, 4, 0124853.

Research output: Contribution to journalArticle

HP1 βis α biomarker for breast cancer prognosis and PARP inhibitor therapy

Lee, Y. H., Liu, X., Qiu, F., O'Connor, T. R., Yen, Y. & Ann, D. K., Mar 13 2015, In : PLoS One. 10, 3, e0121207.

Research output: Contribution to journalArticle

2012

The utility of tumor-specifically internalizing peptides for targeted siRNA delivery into human solid tumors

Un, F., Zhou, B. & Yen, Y., Nov 1 2012, In : Anticancer Research. 32, 11, p. 4685-4690 6 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2014

Identification of a distinct small cell population from human bone marrow reveals its multipotency in vivo and in vitro

Wang, J., Guo, X., Lui, M., Chu, P. J., Yoo, J., Chang, M. & Yen, Y., Jan 17 2014, In : PLoS One. 9, 1, e85112.

Research output: Contribution to journalArticle

8 Citations (Scopus)
2015

Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA

Sun, G., Yeh, S. Y., Yuan, C. W. Y., Chiu, M. J. Y., Yung, B. S. H. & Yen, Y., Jan 27 2015, In : Molecular Therapy - Nucleic Acids. 4, 1, p. e221 e221.

Research output: Contribution to journalArticle

14 Citations (Scopus)
2019

Randomized trial of oral cyclophosphamide versus oral cyclophosphamide with celecoxib for recurrent epithelial ovarian, fallopian tube, and primary peritoneal cancer

Gupta, R., Cristea, M., Frankel, P., Ruel, C., Chen, C., Wang, Y., Morgan, R., Leong, L., Chow, W., Koczywas, M., Koehler, S., Lim, D., Luu, T., Martel, C., McNamara, M., Somlo, G., Twardowski, P., Yen, Y., Idorenyi, A., Raechelle, T. & 2 others, Carroll, M. & Chung, V., Jan 1 2019, In : Cancer Treatment and Research Communications. 21, 100155.

Research output: Contribution to journalArticle

2012

Bortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NFκB signaling, and synergizes with an ERK inhibitor

Yang, F., Jove, V., Chang, S., Hedvat, M., Liu, L., Buettner, R., Tian, Y., Scuto, A., Wen, W., Yip, M. L. R., Van Meter, T. E., Yen, Y. & Jove, R., Apr 1 2012, In : Cancer Biology and Therapy. 13, 6, p. 349-357 9 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
2020

Cybersecurity in Science and Medicine: Threats and Challenges

Luh, F. & Yen, Y., 2020, (Accepted/In press) In : Trends in Biotechnology.

Research output: Contribution to journalShort survey

2011

p53R2 inhibits the proliferation of human cancer cells in association with cell-cycle arrest

Zhang, K., Wu, J., Wu, X., Wang, X., Wang, Y., Zhou, N., Kuo, M. L., Liu, X., Zhou, B., Chang, L., Ann, D. & Yen, Y., Feb 2011, In : Molecular Cancer Therapeutics. 10, 2, p. 269-278 10 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels

Kretzner, L., Scuto, A., Dino, P. M., Kowolik, C. M., Wu, J., Ventura, P., Jove, R., Forman, S. J., Yen, Y. & Kirschbaum, M. H., Jun 1 2011, In : Cancer Research. 71, 11, p. 3912-3920 9 p.

Research output: Contribution to journalArticle

78 Citations (Scopus)
2020
Open Access
2013

Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma

Zhang, K., Chu, K., Wu, X., Gao, H., Wang, J., Yuan, Y. C., Loera, S., Ho, K., Wang, Y., Chow, W., Un, F., Chu, P. & Yen, Y., Jan 15 2013, In : Cancer Research. 73, 4, p. 1298-1307 10 p.

Research output: Contribution to journalArticle

54 Citations (Scopus)
2012

Ribonucleotide reductase and non-small cell lung cancer

Hsu, N. Y., Lee, H., Cheng, Y. W. & Yen, Y., Jan 1 2012, In : Chinese Journal of Lung Cancer. 15, 11, p. 619-623 5 p.

Research output: Contribution to journalArticle

2016

Precision Medicine and Pancreatic Cancer

Farrell, J. J., Moughan, J., Wong, J. L., Regine, W. F., Schaefer, P., Benson, A. B., Macdonald, J. S., Liu, X., Yen, Y., Lai, R., Zheng, Z., Bepler, G., Guha, C. & Elsaleh, H., Nov 1 2016, In : Pancreas. 45, 10, p. 1485-1493 9 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)
2012

RRM2B suppresses activation of the oxidative stress pathway and is Up-regulated by P53 during senescence

Kuo, M. L., Sy, A. J., Xue, L., Chi, M., Michelle, M. T., Yen, T., Chiang, M. I., Chang, L., Chu, P. & Yen, Y., Nov 22 2012, In : Scientific Reports. 2, 822.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2016

The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells

Chen, C. W., Tsao, N., Huang, L. Y., Yen, Y., Liu, X., Lehman, C., Wang, Y. H., Tseng, M. C., Chen, Y. J., Ho, Y. C., Chen, C. F. & Chang, Z. F., Aug 2 2016, In : Cell Reports. 16, 5, p. 1287-1299 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2014

Frequent overexpression of HMGA2 in human atypical teratoid/rhabdoid tumor and its correlation with let-7a3/let-7b miRNA

Zhang, K., Gao, H., Wu, X., Wang, J., Zhou, W., Sun, G., Wang, J., Wang, Y., Mu, B., Kim, C., Chu, P., Ho, D. M., Ann, D. K., Wong, T. T. & Yen, Y., 2014, In : Clinical Cancer Research. 20, 5, p. 1179-1189 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers

Zhang, H., Liu, X., Warden, C. D., Huang, Y., Loera, S., Xue, L., Zhang, S., Chu, P., Zheng, S. & Yen, Y., Sep 11 2014, In : BMC Cancer. 14, 1, 664.

Research output: Contribution to journalArticle

23 Citations (Scopus)
2012

De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer

Wu, X., Somlo, G., Yu, Y., Palomares, M. R., Li, A. X., Zhou, W., Chow, A., Yen, Y., Rossi, J. J., Gao, H., Wang, J., Yuan, Y. C., Frankel, P., Li, S., Ashing-Giwa, K. T., Sun, G., Wang, Y., Smith, R., Robinson, K., Ren, X. & 1 others, Wang, S. E., Mar 8 2012, In : Journal of Translational Medicine. 10, 1, 42.

Research output: Contribution to journalArticle

150 Citations (Scopus)
2013

First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies

Weiss, G. J., Chao, J., Neidhart, J. D., Ramanathan, R. K., Bassett, D., Neidhart, J. A., Choi, C. H. J., Chow, W., Chung, V., Forman, S. J., Garmey, E., Hwang, J., Kalinoski, D. L., Koczywas, M., Longmate, J., Melton, R. J., Morgan, R., Oliver, J., Peterkin, J. J., Ryan, J. L. & 5 others, Schluep, T., Synold, T. W., Twardowski, P., Davis, M. E. & Yen, Y., Aug 1 2013, In : Investigational New Drugs. 31, 4, p. 986-1000 15 p.

Research output: Contribution to journalArticle

122 Citations (Scopus)
2014

Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro

Chin, Y. T., Hsieh, M. T., Yang, S. H., Tsai, P. W., Wang, S. H., Wang, C. C., Lee, Y. S., Cheng, G. Y., HuangFu, W. C., London, D., Tang, H. Y., Fu, E., Yen, Y., Liu, L. F., Lin, H. Y. & Davis, P. J., 2014, In : Oncotarget. 5, 24, p. 12891-12907 17 p.

Research output: Contribution to journalArticle

Open Access
46 Citations (Scopus)

Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA

Zuckerman, J. E., Gritli, I., Tolcher, A., Heidel, J. D., Lim, D., Morgan, R., Chmielowski, B., Ribas, A., Davis, M. E. & Yen, Y., Aug 5 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 31, p. 11449-11454 6 p.

Research output: Contribution to journalArticle

182 Citations (Scopus)
2011

Phase II trial of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehydethiosemicarbazone plus gemcitabine in patients with advanced biliary tract cancer

Ocean, A. J., Christos, P., Sparano, J. A., Matulich, D., Kaubish, A., Siegel, A., Sung, M., Ward, M. M., Hamel, N., Espinoza-Delgado, I., Yen, Y. & Lane, M. E., Aug 1 2011, In : Cancer Chemotherapy and Pharmacology. 68, 2, p. 379-388 10 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
2013

Expression of DNA translesion synthesis polymerase η in head and neck squamous cell cancer predicts resistance to gemcitabine and cisplatin-based chemotherapy

Zhou, W., Chen, Y. W., Liu, X., Chu, P., Loria, S., Wang, Y., Yen, Y. & Chou, K. M., Dec 20 2013, In : PLoS One. 8, 12, e83978.

Research output: Contribution to journalArticle

32 Citations (Scopus)
2017

Mechanism and clinical properties of stembios cell therapy: Induction of early osseointegration in novel dental implants

Weng, C. C., Ou, K. L., Wu, C. Y., Huang, Y. H., Wang, J., Yen, Y., Cheng, H. Y. & Lin, Y. H., 2017, In : International Journal of Oral and Maxillofacial Implants. 32, 1, p. e47-e54

Research output: Contribution to journalArticle

2015

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: Resistance reversal with WNT inhibitor

Tzeng, H. E., Yang, L., Chen, K., Wang, Y., Liu, Y. R., Pan, S. L., Gaur, S., Hu, S. & Yen, Y., 2015, In : Oncotarget. 6, 13, p. 11061-11073 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)
2018

Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer

Xue, L., Liu, X., Wang, Q., Liu, C. Q., Chen, Y., Jia, W., Hsie, R., Chen, Y., Luh, F., Zheng, S. & Yen, Y., Jan 1 2018, In : American Journal of Translational Research. 10, 11, p. 3635-3649 15 p., AJTR0084684.

Research output: Contribution to journalArticle

1 Citation (Scopus)

Web-based platform vs genetic counselors in educating patients about carrier results from exome sequencing

Yen, Y. & Luh, F., Jul 1 2018, In : JAMA Internal Medicine. 178, 7, p. 998-999 2 p.

Research output: Contribution to journalLetter

1 Citation (Scopus)
2017

Overexpression of uridine-cytidine kinase 2 correlates with breast cancer progression and poor prognosis

Shen, G., He, P., Mao, Y., Li, P., Luh, F., Ding, G., Liu, X. & Yen, Y., Jun 1 2017, In : Journal of Breast Cancer. 20, 2, p. 132-141 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)
2019

Chicken-Derived Humanized Antibody Targeting a Novel Epitope F2pep of Fibroblast Growth Factor Receptor 2: Potential Cancer Therapeutic Agent

Tsai, K. C., Chang, C. D., Cheng, M. H., Lin, T. Y., Lo, Y. N., Yang, T. W., Chang, F. L., Chiang, C. W., Lee, Y. C. & Yen, Y., Jan 31 2019, In : ACS Omega. 4, 1, p. 2387-2397 11 p.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)
2018

FDA guidance for next generation sequencing-based testing: balancing regulation and innovation in precision medicine

Luh, F. & Yen, Y., Dec 1 2018, In : npj Genomic Medicine. 3, 1, 28.

Research output: Contribution to journalComment/debate

9 Citations (Scopus)
2017

Human mitochondrial pyrroline-5-carboxylate reductase 1 promotes invasiveness and impacts survival in breast cancers

Ding, J., Kuo, M. L., Su, L., Xue, L., Luh, F., Zhang, H., Wang, J., Lin, T. G., Zhang, K., Chu, P., Zheng, S., Liu, X. & Yen, Y., May 1 2017, In : Carcinogenesis. 38, 5, p. 519-531 13 p., bgx022.

Research output: Contribution to journalArticle

31 Citations (Scopus)
2016

Signature miRNAs in colorectal cancers were revealed using a bias reduction small RNA deep sequencing protocol

Sun, G., Cheng, Y. W., Lai, L., Huang, T. C., Wang, J., Wu, X., Wang, Y., Huang, Y., Wang, J., Zhang, K., Hu, S., Yang, J. R. & Yen, Y., 2016, In : Oncotarget. 7, 4, p. 3857-3872 16 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2018

A homozygous variant in RRM2B is associated with severe metabolic acidosis and early neonatal death

Penque, B. A., Su, L., Wang, J., Ji, W., Bale, A., Luh, F., Fulbright, R. K., Sarmast, U., Sega, A. G., Konstantino, M., Spencer-Manzon, M., Pierce, R., Yen, Y. & Lakhani, S. A., Jan 1 2018, (Accepted/In press) In : European Journal of Medical Genetics.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Phase IB trial of ixabepilone and vorinostat in metastatic breast cancer

Luu, T., Kim, K. P., Blanchard, S., Anyang, B., Hurria, A., Yang, L., Beumer, J. H., Somlo, G. & Yen, Y., Jan 1 2018, In : Breast Cancer Research and Treatment. 167, 2, p. 469-478 10 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)
2020

Upregulation of protein synthesis and proteasome degradation confers sensitivity to proteasome inhibitor bortezomib in myc-atypical teratoid/rhabdoid tumors

Tran, H. M., Wu, K. S., Sung, S. Y., Changou, C. A., Hsieh, T. H., Liu, Y. R., Liu, Y. L., Tsai, M. L., Lee, H. L., Hsieh, K. L. C., Huang, W. C., Liang, M. L., Chen, H. H., Lee, Y. Y., Lin, S. C., Ho, D. M. T., Chang, F. C., Chao, M. E., Chen, W., Chu, S. S. & 4 others, Yu, A. L., Yen, Y., Chang, C. C. & Wong, T. T., Mar 22 2020, In : Cancers. 12, 3, 752.

Research output: Contribution to journalArticle

Open Access
2014

Reciprocal regulation of autophagy and dNTP pools in human cancer cells

Chen, W., Zhang, L., Zhang, K., Zhou, B., Kuo, M. L., Hu, S., Chen, L., Tang, M., Chen, Y. R., Yang, L., Ann, D. K. & Yen, Y., Jan 1 2014, In : Autophagy. 10, 7, p. 1272-1284 13 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)
2016

Proton pump inhibitors and risk of periampullary cancers - A nested case-control study

Chien, L-N., Huang, Y. J., Shao, Y-H., Chang, C. J., Chuang, M. T., Chiou, H-Y. & Yen, Y., Mar 15 2016, In : International Journal of Cancer. 138, 6, p. 1401-1409 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2015

RRM2B-mediated regulation of mitochondrial activity and inflammation under oxidative stress

Cho, E. C., Kuo, M. L., Cheng, J. H., Cheng, Y. C., Hsieh, Y. C., Liu, Y. R., Hsieh, R. H. & Yen, Y., 2015, In : Mediators of Inflammation. 2015, 287345.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Lovastatin overcomes gefitinib resistance through TNF-a signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo

Yang, S. H., Lin, H. Y., Chang, V. H. S., Chen, C. C., Liu, Y. R., Wang, J., Zhang, K., Jiang, X. & Yen, Y., 2015, In : Oncotarget. 6, 27, p. 23857-23873 17 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)