Find Research outputs

2021

A macrolide from Streptomyces sp. modulates apoptosis and autophagy through Mcl-1 downregulation in human breast cancer cells

Chiu, C. F., Chiu, S. J., Bai, L. Y., Feng, C. H., Hu, J. L., Lin, W. Y., Huang, H. Y. & Weng, J. R., 2021, (Accepted/In press) In: Environmental Toxicology. 36, 7, p. 1316-1325 10 p.

Research output: Contribution to journal › Article › peer-review

Marine Antimicrobial Peptide TP4 Exerts Anticancer Effects on Human Synovial Sarcoma Cells via Calcium Overload, Reactive Oxygen Species Production and Mitochondrial Hyperpolarization

Su, B. C., Hung, G. Y., Tu, Y. C., Yeh, W. C., Lin, M. C. & Chen, J. Y., Feb 5 2021, In: Marine Drugs. 19, 2

Research output: Contribution to journal › Article › peer-review

Open Access

2020

13-acetoxysarcocrassolide exhibits cytotoxic activity against oral cancer cells through the interruption of the keap1/Nrf2/p62/SQSTM1 pathway: The need to move beyond classical concepts

Liu, Y. C., Peng, B. R., Hsu, K. C., El-Shazly, M., Shih, S. P., Lin, T. E., Kuo, F. W., Chou, Y. C., Lin, H. Y. & Lu, M. C., Jul 23 2020, In: Marine Drugs. 18, 8, 382.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Anti-acne effects of cembrene diterpenoids from the cultured soft coral sinularia flexibilis

Chen, L. W., Chung, H. L., Wang, C. C., Su, J. H., Chen, Y. J. & Lee, C. J., Oct 2020, In: Marine Drugs. 18, 10, 487.

Research output: Contribution to journal › Article › peer-review

Open Access

Anti-inflammatory effects of peptides from a marine algicolous fungus acremonium sp. Ntu492 in bv-2 microglial cells

Hsiao, G., Wang, S. W., Chiang, Y. R., Chi, W. C., Kuo, Y. H., Phong, D. A., Chen, C. Y. & Lee, T. H., 2020, In: Journal of Food and Drug Analysis. 28, 2, p. 283-291 9 p., 9.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Author Correction: FTY720 Induces Autophagy-Associated Apoptosis in Human Oral Squamous Carcinoma Cells, in Part, through a Reactive Oxygen Species/Mcl-1-Dependent Mechanism (Scientific Reports, (2017), 7, 1, (5600), 10.1038/s41598-017-06047-9)

Bai, L. Y., Chiu, C. F., Chiu, S. J., Chu, P. C. & Weng, J. R., Dec 1 2020, In: Scientific Reports. 10, 1, 3322.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

Biomass and Lipid Production Potential of an Indian Marine Algal Isolate Tetraselmis striata BBRR1

Boopathy, A. B., Jayakumar, T., Chinnasamy, S., Rajaram, M. G., Mohan, N., Nagaraj, S., Rengasamy, R., Manubolu, M., Sheu, J. R. & Chang, C. C., Jan 1 2020, In: Energies. 13, 2, 341.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Calcium-dependent calpain activation-mediated mitochondrial dysfunction and oxidative stress are required for cytotoxicity of epinecidin-1 in human synovial sarcoma SW982 cells

Su, B. C., Li, C. C., Horng, J. L. & Chen, J. Y., Mar 2 2020, In: International Journal of Molecular Sciences. 21, 6, 2109.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Dietary supplementation of recombinant tilapia piscidin 4-expressing yeast enhances growth and immune response in Lates calcarifer

Huang, H. N., Su, B. C., Tsai, T. Y., Rajanbabu, V., Pan, C. Y. & Chen, J. Y., Mar 2020, In: Aquaculture Reports. 16, 100254.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Leucettamine B analogs and their carborane derivative as potential anti-cancer agents: Design, synthesis, and biological evaluation

Hsu, M. H., Hsieh, C. Y., Kapoor, M., Chang, J. H., Chu, H. L., Cheng, T. M., Hsu, K. C., Lin, T. E., Tsai, F. Y. & Horng, J. C., May 2020, In: Bioorganic Chemistry. 98, 103729.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Protective effects of fucoxanthin on high glucoseand 4-hydroxynonenal (4-HNE)-induced injury in human retinal pigment epithelial cells

Chiang, Y. F., Chen, H. Y., Chang, Y. J., Shih, Y. H., Shieh, T. M., Wang, K. L. & Hsia, S. M., Dec 2020, In: Antioxidants. 9, 12, p. 1-15 15 p., 1176.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents

Peng, B. R., Lai, K. H., Chang, Y. C., Chen, Y. Y., Su, J. H., Huang, Y. M., Chen, P. J., Yu, S. S. F., Duh, C. Y. & Sung, P. J., Aug 19 2020, In: Marine Drugs. 18, 9, 434.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Analysis of Zobellella denitrificans ZD1 draft genome: Genes and gene clusters responsible for high polyhydroxybutyrate (PHB) production from glycerol under saline conditions and its CRISPR-Cas system

Wu, Y. W., Yang, S. H., Hwangbo, M. & Chu, K. H., Jan 1 2019, In: PLoS ONE. 14, 9, e0222143.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Hirsutanol A attenuates lipopolysaccharide-mediated matrix metalloproteinase 9 expression and cytokines production and improves endotoxemia-induced acute sickness behavior and acute lung injury

Jan, J. S., Yang, C. H., Wang, M. H., Lin, F. L., Yen, J. L., Hsieh, I., Khotimchenko, M., Lee, T. H. & Hsiao, G., Jun 17 2019, In: Marine Drugs. 17, 6, 360.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Multidisciplinary approach in study of the zoonotic Anisakis larval infection in the blue mackerel (Scomber australasicus) and the largehead hairtail (Trichiurus lepturus) in Northern Taiwan

Sonko, P., Chih-Cheng Chen, S., Chou, C. M., Huang, Y. C., Hsu, S. L., Barčák, D., Oros, M. & Fan, C. K., Jan 1 2019, In: Journal of Microbiology, Immunology and Infection. 53, 6, p. 1021-1029 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Pardaxin Promoted Differentiation and Maturation of Leukemic Cells via Regulating TLR2/MyD88 Signal against Cell Proliferation

Uen, W. C., Choong, C. Y., Tai, C. J. & Tai, C. J., Jan 1 2019, In: Evidence-based Complementary and Alternative Medicine. 2019, 7035087.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Risk factors of synchronous multifocal necrotizing fasciitis: A case control study in comparison with monofocal necrotizing fasciitis in Taiwan

Lee, C. Y., Huang, T. W., Wu, M. H., Huang, T. J., Li, Y. R., Huang, E. J. C. & Tsai, Y. H., Jun 11 2019, In: BMC Infectious Diseases. 19, 1, 513.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Citations (Scopus)

2018

Aquaculture soft coral lobophytum crassum as a producer of anti-proliferative cembranoids

Peng, B. R., Lu, M. C., El-Shazly, M., Wu, S. L., Lai, K. H. & Su, J. H., Jan 2018, In: Marine Drugs. 16, 1, 15.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (Scopus)

Biofuel and biochemical analysis of amphora coffeaeformis RR03, a novel marine diatom, cultivated in an open raceway pond

Rajaram, M. G., Nagaraj, S., Manjunath, M., Boopathy, A. B., Kurinjimalar, C., Rengasamy, R., Jayakumar, T., Sheu, J. R. & Li, J. Y., Jun 1 2018, In: Energies. 11, 6, en11061341.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Fucoxanthin attenuates fatty acid-induced lipid accumulation in FL83B hepatocytes through regulated Sirt1/AMPK signaling pathway

Chang, Y. H., Chen, Y. L., Huang, W. C. & Liou, C. J., Jan 1 2018, In: Biochemical and Biophysical Research Communications. 495, 1, p. 197-203 7 p.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Heteronemin, a marine sesterterpenoid-type metabolite, induces apoptosis in prostate lncap cells via oxidative and er stress combined with the inhibition of topoisomerase II and Hsp90

Lee, M. G., Liu, Y. C., Lee, Y. L., El-Shazly, M., Lai, K. H., Shih, S. P., Ke, S. C., Hong, M. C., Du, Y. C., Yang, J. C., Sung, P. J., Wen, Z. H. & Lu, M. C., Jun 2018, In: Marine Drugs. 16, 6, 204.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Citations (Scopus)

Preparation of 4-Deoxy- L -erythro-5-hexoseulose Uronic Acid (DEH) and Guluronic Acid Rich Alginate Using a Unique exo-Alginate Lyase from Thalassotalea crassostreae

Wang, D., Aarstad, O. A., Li, J., McKee, L. S., Sætrom, G. I., Vyas, A., Srivastava, V., Aachmann, F. L., Bulone, V. & Hsieh, Y. S., Feb 14 2018, In: Journal of Agricultural and Food Chemistry. 66, 6, p. 1435-1443 9 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Type and quantity of coastal debris pollution in Taiwan: A 12-year nationwide assessment using citizen science data

Walther, B. A., Kunz, A. & Hu, C-S., 2018, In: Marine Pollution Bulletin. 135, p. 862-872 11 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

2017

Hirsutane-Type Sesquiterpenes with Inhibitory Activity of Microglial Nitric Oxide Production from the Red Alga-Derived Fungus Chondrostereum sp. NTOU4196

Hsiao, G., Chi, W. C., Pang, K. L., Chen, J. J., Kuo, Y. H., Wang, Y. K., Cha, H. J., Chou, S. C. & Lee, T. H., May 26 2017, In: Journal of Natural Products. 80, 5, p. 1615-1622 8 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

2016

Angiogenesis Inhibitors and Anti-Inflammatory Agents from Phoma sp. NTOU4195

Lee, M. S., Wang, S. W., Wang, G. J., Pang, K. L., Lee, C. K., Kuo, Y. H., Cha, H. J., Lin, R. K. & Lee, T. H., Dec 23 2016, In: Journal of Natural Products. 79, 12, p. 2983-2990 8 p.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Dual-compartmental transcriptomic + proteomic analysis of a marine endosymbiosis exposed to environmental change

Mayfield, A. B., Wang, Y. B., Chen, C. S., Chen, S. H. & Lin, C. Y., Dec 1 2016, In: Molecular Ecology. 25, 23, p. 5944-5958 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center

Lee, C. Y., Li, Y. Y., Huang, T. W., Huang, T. Y., Hsu, W. H., Tsai, Y. H., Huang, J. C. & Huang, K. C., Dec 1 2016, In: Infection. 44, 6, p. 757-763 7 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

2015

Anti-restenotic roles of dihydroaustrasulfone alcohol involved in inhibiting PDGF-BB-stimulated proliferation and migration of vascular smooth muscle cells

Li, P. C., Sheu, M. J., Ma, W. F., Pan, C. H., Sheu, J. H. & Wu, C. H., May 1 2015, In: Marine Drugs. 13, 5, p. 3046-3060 15 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

De novo assembly of the whole transcriptome of the wild embryo, preleptocephalus, leptocephalus, and glass eel of Anguilla japonica and deciphering the digestive and absorptive capacities during early development

Hsu, H. Y., Chen, S. H., Cha, Y. R., Tsukamoto, K., Lin, C. Y. & Han, Y. S., Sep 25 2015, In: PLoS ONE. 10, 9, e0139105.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Erratum: The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin (Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (10798-10803))

Lee, C. T., Chen, I. T., Yang, Y. T., Ko, T. P., Huang, Y. T., Huang, J. Y., Huang, M. F., Lin, S. J., Chen, C. Y., Lin, S. S., Lightner, D. V., Wang, H. C., Wang, A. H. J., Wang, H. C., Hor, L. I. & Lo, C. F., Sep 29 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 39, p. E5445

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Heteronemin, a spongean sesterterpene, induces cell apoptosis and autophagy in human renal carcinoma cells

Wu, S. Y., Sung, P. J., Chang, Y. L., Pan, S. L. & Teng, C. M., 2015, In: BioMed Research International. 2015, 738241.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Photobacterium damselae subsp. piscicida responds to antimicrobial peptides through phage-shock-protein A (PspA)-related extracytoplasmic stress response system

Tsai, W. C., Kuo, T. Y., Lin, C. Y., Lin, J. C. & Chen, W. J., Jan 1 2015, In: Journal of Applied Microbiology. 118, 1, p. 27-38 12 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

The Multipart Copolyelectrolyte Adhesive System of the Sandcastle Worm: The Biological Insights for Developoing a Synthetic Underwater Adhesive

Wang, C-S., 2015

Research output: Types of Thesis › Doctoral Thesis

The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin

Lee, C. T., Chen, I. T., Yang, Y. T., Ko, T. P., Huang, Y. T., Huang, J. Y., Huang, M. F., Lin, S. J., Chen, C. Y., Lin, S. S., Lightner, D. V., Wang, H. C., Wang, A. H. J., Wang, H. C., Hor, L. I. & Lo, C. F., Aug 25 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 34, p. 10798-10803 6 p.

Research output: Contribution to journal › Article › peer-review

247 Citations (Scopus)

2014

Inhibitory effect of dihydroaustrasulfone alcohol on the migration of human non-small cell lung carcinoma A549 cells and the antitumor effect on a Lewis lung carcinoma-bearing tumor model in C57BL/6J mice

Chen, S. C., Chien, Y. C., Pan, C. H., Sheu, J. H., Chen, C. Y. & Wu, C. H., Jan 2014, In: Marine Drugs. 12, 1, p. 196-213 18 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

2013

A soft coral natural product, 11-episinulariolide acetate, inhibits gene expression of cyclooxygenase-2 and interleukin-8 through attenuation of calcium signaling

Hsu, W. L., Chiu, S. J., Tsai, Y. T., Chang, C. M., Wang, J. Y., Wang, E. T., Hou, M. F., Huang, C. Y., Sheu, J. H. & Chang, W. C., Jun 2013, In: Molecules. 18, 6, p. 7023-7034 12 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

2012

Localization of the bioadhesive precursors of the sandcastle worm, Phragmatopoma californica (Fewkes)

Wang, C. S. & Stewart, R. J., Jan 2012, In: Journal of Experimental Biology. 215, 2, p. 351-361 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Citations (Scopus)

2010

Morphology of the Adhesive System in the Sandcastle Worm, Phragmatopoma californica

Wang, C. S., Svendsen, K. K. & Stewart, R. J., 2010, Biological Adhesive Systems: From Nature to Technical and Medical Application. von Byern, J. & Grunwald, I. (eds.). Vienna: Springer Vienna, p. 169-179 11 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2007

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway

Lu, P. H., Chueh, S. C., Kung, F. L., Pan, S. L., Shen, Y. C. & Guh, J. H., Feb 5 2007, In: European Journal of Pharmacology. 556, 1-3, p. 45-54 10 p.

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

2005

Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma

Chiang, P. C., Chien, C. L., Pan, S. L., Chen, W. P., Teng, C. M., Shen, Y. C. & Guh, J. H., Oct 2005, In: Journal of Hepatology. 43, 4, p. 679-686 8 p.

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Prorocentin, a new polyketide from the marine dinoflagellate Prorocentrum lima

Lu, C. K., Chou, H. N., Lee, C. K. & Li, Z-H., Sep 1 2005, In: Organic Letters. 7, 18, p. 3893-3896 4 p.

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

2004

Vibrio vulnificus in Taiwan

Hsueh, P. R., Lin, C. Y., Tang, H. J., Lee, H. C., Liu, J. W., Liu, Y. C. & Chuang, Y. C., Aug 2004, In: Emerging Infectious Diseases. 10, 8, p. 1363-1368 6 p.

Research output: Contribution to journal › Article › peer-review

98 Citations (Scopus)

2003

Bioaccumulation and elimination of tributyltin and triphenyltin in oysters and rock shells in Taiwan

Meng, P. J., Han, B. C., Hsu, W. K., Chuang, A., Cheng, J. H. & Hung, T. C., Jun 2003, In: Journal of Food and Drug Analysis. 11, 2, p. 96-101 6 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

2000

Mussel Watch: A review of Cu and other metals in various marine organisms in Taiwan, 1991-98

Jeng, M. S., Jeng, W. L., Hung, T. C., Yeh, C-Y., Tseng, R. J., Meng, P. J. & Han, B. C., Nov 2000, In: Environmental Pollution. 110, 2, p. 207-215 9 p.

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

1999

Normalization of sedimentary lipid biomarker concentrations to total organic carbon in principal component analysis

Jeng, W. L. & Han, B. C., 1999, In: International Journal of Environmental Analytical Chemistry. 73, 1, p. 15-29 15 p.

Research output: Contribution to journal › Article › peer-review

1997

Echovirus 1 interaction with the human very late antigen-2 (integrin α2β1) I domain: Identification of two independent virus contact sites distinct from the metal ion-dependent adhesion site

King, S. L., Kamata, T., Cunningham, J. A., Emsley, J., Liddington, R. C., Takada, Y. & Bergelson, J. M., Nov 7 1997, In: Journal of Biological Chemistry. 272, 45, p. 28518-28522 5 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Marine Environmental Monitoring and QA/QC System in Taiwan

洪楚璋, 凌永健, 鄭偉力, 黃哲崇 & Han, B-C., Jun 1997, In: Environmental Protection. 20, 1, p. 69-90 22 p.

Research output: Contribution to journal › Article › peer-review

1996

Coprostanol distribution in marine sediments off southwestern Taiwan

Jeng, W. L., Wang, J. & Han, B. C., 1996, In: Environmental Pollution. 94, 1, p. 47-52 6 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Relationship between copper speciation in sediments and bioaccumulation by marine bivalves of Taiwan

Han, B. C., Jeng, W. L., Hung, T. C. & Wen, M. Y., 1996, In: Environmental Pollution. 91, 1, p. 35-39 5 p.

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

1986

Ureidoglycollate lyase, a new metalloenzyme of peroxisomal urate degradation in marine fish liver.

Takada, Y. & Noguchi, T., Apr 15 1986, In: Biochemical Journal. 235, 2, p. 391-397 7 p.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

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