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• Activation of NPFFR2 leads to hyperalgesia through the spinal inflammatory mediator CGRP in mice

  Lin, Y. T., Liu, H. L., Day, Y. J., Chang, C. C., Hsu, P. H. & Chen, J. C., May 2017, In: Experimental Neurology. 291, p. 62-73 12 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Activation of NF-κB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKβ expression

  Chen, P. M., Wu, T. C., Wang, Y. C., Cheng, Y. W., Sheu, G. T., Chen, C. Y. & Lee, H., Nov 2013, In: Carcinogenesis. 34, 11, p. 2655-2663 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  32 Citations (Scopus)

• Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

  Yang, T. T., Chang, C. K., Tsao, C. W., Hsu, Y. M., Hsu, C. T. & Cheng, J. T., Feb 13 2009, In: Neuroscience Letters. 451, 1, p. 57-59 3 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Activation of mitogen-activated protein kinase by oxidized low-density lipoprotein in canine cultured vascular smooth muscle cells

  Yang, C. M., Chiu, C. T., Wang, C. C., Chien, C. S., Hsiao, L. D., Lin, C. C., Tu, M. T. & Pan, S. L., Apr 2000, In: Cellular Signalling. 12, 4, p. 205-214 10 p.

  Research output: Contribution to journal › Article › peer-review
  34 Citations (Scopus)

• Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish Application of Zebrafish in Biomedical Research

  Chou, C. M., Chen, Y. C., Su, S., Chen, G. D., Huang, K. Y., Lien, H. W., Huang, C. J. & Cheng, C. H., Nov 17 2015, In: Journal of Biomedical Science. 22, 1, 102.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• Activation of kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2/antioxidant response element pathway by curcumin enhances the anti-oxidative capacity of corneal endothelial cells

  Guo, S. P., Chang, H. C., Lu, L. S., Liu, D. Z. & Wang, T. J., Sep 2021, In: Biomedicine and Pharmacotherapy. 141, 111834.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  5 Citations (Scopus)

• Activation of JNK contributes to evodiamine-induced apoptosis and G ₂/M arrest in human colorectal carcinoma cells: A structure-activity study of evodiamine

  Chien, C. C., Wu, M. S., Shen, S. C., Ko, C. H., Chen, C. H., Yang, L. L. & Chen, Y. C., Jun 24 2014, In: PLoS One. 9, 6, e99729.

  Research output: Contribution to journal › Article › peer-review
  61 Citations (Scopus)

• Activation of iodosobenzene by catalytic tetrabutylammonium iodide and its application in the oxidation of some isoquinoline alkaloids

  Huang, W. J., Singh, O. V., Chen, C. H., Chiou, S. Y. & Lee, S. S., 2002, In: Helvetica Chimica Acta. 85, 4, p. 1069-1078 10 p.

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)

• Activation of indices of cell-mediated immunity in bipolar mania

  Tsai, S. Y., Chen, K. P., Yang, Y. Y., Chen, C. C., Lee, J-C., Singh, V. K. & Leu, S. J. C., Apr 15 1999, In: Biological Psychiatry. 45, 8, p. 989-994 6 p.

  Research output: Contribution to journal › Article › peer-review
  103 Citations (Scopus)

• Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C₂C₁₂ cells

  Lui, T. N., Tsao, C. W., Huang, S. Y., Chang, C. H. & Cheng, J. T., May 2010, In: Neuroscience Letters. 474, 3, p. 144-147 4 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression

  Chang, T. S., Wu, Y. C., Chi, C. C., Su, W. C., Chang, P. J., Lee, K. F., Tung, T. H., Wang, J., Liu, J-J., Tung, S. Y., Kuo, L. M., Ho, H. N., Ling, T. Y. & Huang, Y-H., Jan 1 2015, In: Clinical Cancer Research. 21, 1, p. 201-210 10 p.

  Research output: Contribution to journal › Article › peer-review
  77 Citations (Scopus)

• Activation of IGF-I survival signaling and its compensative inhibition of the cardiac apoptosis on carotid arteries balloon-injured rat hearts

  Hsieh, C. H., Pai, P., Wu, J. P., Ho, T. J., Wu, C. H., Shibu, M. A., Day, C. H., Viswanadha, V. P., Chuang, H. L. & Huang, C. Y., 2017, In: Chinese Journal of Physiology. 60, 3, p. 166-173 8 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone

  Huang, H. S., Chiou, J. F., Fong, Y., Hou, C. C., Lu, Y. C., Wang, J. Y., Shih, J. W., Pan, Y. R. & Lin, J. J., Jul 17 2003, In: Journal of Medicinal Chemistry. 46, 15, p. 3300-3307 8 p.

  Research output: Contribution to journal › Article › peer-review
  60 Citations (Scopus)

• Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression: Insights into potential pathogenic mechanisms of thyroid-associated ophthalmopathy

  Cao, H. J., Wang, H. S., Zhang, Y., Lin, H. Y., Phipps, R. P. & Smith, T. J., Nov 6 1998, In: Journal of Biological Chemistry. 273, 45, p. 29615-29625 11 p.

  Research output: Contribution to journal › Article › peer-review
  179 Citations (Scopus)

• Activation of heme oxygenase-1 by Ginkgo biloba extract differentially modulates endothelial and smooth muscle-like progenitor cells for vascular repair

  Wu, T. C., Chen, J. S., Wang, C. H., Huang, P. H., Lin, F. Y., Lin, L. Y., Lin, S. J. & Chen, J. W., Dec 1 2019, In: Scientific Reports. 9, 1, 17316.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  7 Citations (Scopus)

• Activation of gonadotropin-releasing hormone receptors produces neuronal excitation in the rat hippocampus

  Lu, F., Yang, J. M., Wu, J. N., Chen, Y. C., Kao, Y. H., Tung, C. S. & Yang, S. N., 1999, In: Chinese Journal of Physiology. 42, 2, p. 67-71 5 p.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• Activation of free fatty acid receptor 1 improves hepatic steatosis through a p38-dependent pathway

  Ou, H. Y., Wu, H. T., Lu, F. H., Su, Y. C., Hung, H. C., Wu, J. S., Yang, Y. C., Wu, C. L. & Chang, C. J., Jul 9 2014, In: Journal of Molecular Endocrinology. 53, 2, p. 165-174 10 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells

  Chen, P. C., Lee, W. Y., Ling, H. H., Cheng, C. H., Chen, K. C. & Lin, C. W., Jun 2018, In: Journal of Cellular Physiology. 233, 6, p. 4972-4980 9 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• Activation of fibroblast growth factor 8 gene expression in human embryonal carcinoma cells

  Wu, J., Payson, R. A., Lang, J. C. & Chiu, I. M., May 1997, In: Journal of Steroid Biochemistry and Molecular Biology. 62, 1, p. 1-10 10 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression

  Wang, Y. N., Chen, Y. J. & Chang, W. C., Jan 2006, In: Molecular Pharmacology. 69, 1, p. 85-98 14 p.

  Research output: Contribution to journal › Article › peer-review
  37 Citations (Scopus)

• Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1

  Kawaguchi, M., Onuchic, L. F. & Huang, S. K., May 3 2002, In: Journal of Biological Chemistry. 277, 18, p. 15229-15232 4 p.

  Research output: Contribution to journal › Article › peer-review
  39 Citations (Scopus)

• Activation of estrogen receptors with E2 downregulates peroxisome proliferator-activated receptor γ in hepatocellular carcinoma

  Lin, Y. M., Velmurugan, B. K., Yeh, Y. L., Tu, C. C., Ho, T. J., Lai, T-I., Tsai, C. H., Tsai, F. J., Tsai, C. H. & Huang, C. Y., Dec 2013, In: Oncology Reports. 30, 6, p. 3027-3031 5 p.

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and -independent pathways

  Deng, J. Y., Hsieh, P. S., Huang, J. P., Lu, L. S. & Hung, L. M., Jul 2008, In: Diabetes. 57, 7, p. 1814-1823 10 p.

  Research output: Contribution to journal › Article › peer-review
  128 Citations (Scopus)

• Activation of dopamine D₂-like receptors attenuates pulmonary C-fiber hypersensitivity in rats

  Lin, Y. S., Gu, Q. & Lee, L. Y., Apr 15 2003, In: American Journal of Respiratory and Critical Care Medicine. 167, 8, p. 1096-1101 6 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Activation of DNA methyltransferase 1 by EBV LMP1 involves c-Jun NH 2-terminal kinase signaling

  Tsai, C. L., Li, H. P., Lu, Y. J., Hsueh, C., Liang, Y., Chen, C. L., Tsao, S. W., Tse, K. P., Yu, J. S. & Chang, Y. S., Dec 15 2006, In: Cancer Research. 66, 24, p. 11668-11676 9 p.

  Research output: Contribution to journal › Article › peer-review
  196 Citations (Scopus)

• Activation of deoxyribonuclease I by nicotinamide as a new strategy to attenuate tetracycline-resistant biofilms of cutibacterium acnes

  Shih, Y. H., Liu, D., Chen, Y. C., Liao, M. H., Lee, W. R. & Shen, S. C., Jun 1 2021, In: Pharmaceutics. 13, 6, 819.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  2 Citations (Scopus)

• Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice

  Yang, P. P., Yeh, G. C., Yeh, T. K., Xi, J., Loh, H. H., Law, P. Y. & Tao, P. L., Sep 1 2016, In: Pharmacological Research. 111, p. 867-876 10 p.

  Research output: Contribution to journal › Article › peer-review
  20 Citations (Scopus)

• Activation of Class I histone deacetylases contributes to mitochondrial dysfunction in cardiomyocytes with altered complex activities

  Lkhagva, B., Kao, Y. H., Lee, T. I., Lee, T. W., Cheng, W. L. & Chen, Y. J., Apr 3 2018, In: Epigenetics. 13, 4, p. 376-385 10 p.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• Activation of c-Jun NH₂-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor β-lapachone-induced apoptosis through an oxidation-dependent pathway

  Shiah, S. G., Chuang, S. E., Chau, Y. P., Shen, S. C. & Kuo, M. L., Jan 16 1999, In: Cancer Research. 59, 2, p. 391-398 8 p.

  Research output: Contribution to journal › Article › peer-review
  93 Citations (Scopus)

• Activation of CDC 25 phosphatase and CDC 2 kinase involved in GL331- induced apoptosis

  Huang, T. S., Shu, C. H., Yang, W. K. & Whang-Peng, J., Jul 15 1997, In: Cancer Research. 57, 14, p. 2974-2978 5 p.

  Research output: Contribution to journal › Article › peer-review
  42 Citations (Scopus)

• Activation of brainstem catecholaminergic neurons by conditioned and unconditioned aversive stimuli as revealed by c-Fos immunoreactivity

  Pezzone, M. A., Lee, W. S., Hoffman, G. E., Pezzone, K. M. & Rabin, B. S., Apr 16 1993, In: Brain Research. 608, 2, p. 310-318 9 p.

  Research output: Contribution to journal › Article › peer-review
  148 Citations (Scopus)

• Activation of Brain L-glutamate Decarboxylase 65 Isoform (GAD65) by Phosphorylation at Threonine 95 (T95)

  Chou, C. C., Modi, J. P., Wang, C. Y., Hsu, P. C., Lee, Y-H., Huang, K. F., Wang, A. H. J., Nan, C., Huang, X., Prentice, H., Wei, J. & Wu, J. Y., Mar 1 2017, In: Molecular Neurobiology. 54, 2, p. 866-873 8 p.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• Activation of aryl hydrocarbon receptor by kynurenine impairs progression and metastasis of neuroblastoma

  Wu, P. Y., Yu, I. S., Lin, Y. C., Chang, Y. T., Chen, C. C., Lin, K. H., Tseng, T. H., Kargren, M., Tai, Y. L., Shen, T. L., Liu, Y. L., Wang, B. J., Chang, C. H., Chen, W. M., Juan, H. F., Huang, S. F., Chan, Y. Y., Liao, Y. F., Hsu, W. M. & Lee, H., Nov 1 2019, In: Cancer Research. 79, 21, p. 5550-5562 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  24 Citations (Scopus)

• Activation of a nuclear factor of activated T-lymphocyte-3 (NFAT3) by oxidative stress in carboplatin-mediated renal apoptosis

  Lin, H., Sue, Y. M., Chou, Y., Cheng, C. F., Chang, C. C., Li, H. F., Chen, C. C. & Juan, S. H., Dec 2010, In: British Journal of Pharmacology. 161, 7, p. 1661-1676 16 p.

  Research output: Contribution to journal › Article › peer-review
  28 Citations (Scopus)

• Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock

  Ban, Y., Ho, C. W., Lin, R. K., Lyu, Y. L. & Liu, L. F., 2013, In: Molecular and Cellular Biology. 33, 20, p. 4008-4016 9 p.

  Research output: Contribution to journal › Article › peer-review
  21 Citations (Scopus)

• Activation of a hippocampal CREB-pCREB-miRNA-MEF2 axis modulates individual variation of spatial learning and memory capability

  Wang, I. F., Wang, Y., Yang, Y. H., Huang, G. J., Tsai, K. J. & Shen, C. K. J., Aug 2021, In: Cell Reports. 36, 5, 109477.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• Activation by zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells

  Huang, C. W., Huang, C. C. & Wu, S. N., Apr 2007, In: Journal of Pharmacology and Experimental Therapeutics. 321, 1, p. 98-106 9 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• Activation and up-regulation of nitric oxide synthase in human umbilical vein endothelial cells by polycyclic aromatic hydrocarbons

  Li, C. H., Lee, C. C., Cheng, Y. W., Juang, H. A. & Kang, J. J., Jul 15 2004, In: Toxicology Letters. 151, 2, p. 367-374 8 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• Activation and induction of cytosolic phospholipase A2 by TNF-α mediated through Nox2, MAPKs, NF-κB, and p300 in human tracheal smooth muscle cells

  Lee, C-W., Lin, C-C., Lee, I-T., Lee, H-C. & Yang, C-M., Aug 2011, In: Journal of Cellular Physiology. 226, 8, p. 2103-14 12 p.

  Research output: Contribution to journal › Article › peer-review
  55 Citations (Scopus)

• Activation and induction of cytosolic phospholipase A₂ by IL-1β in human tracheal smooth muscle cells: Role of MAPKs/p300 and NF-κB

  Lee, C. W., Lee, I. T., Lin, C. C., Lee, H. C., Lin, W. N. & Yang, C. M., Apr 1 2010, In: Journal of Cellular Biochemistry. 109, 5, p. 1045-1056 12 p.

  Research output: Contribution to journal › Article › peer-review
  16 Citations (Scopus)

• Activating transcription factor 3 protects against pressure-overload heart failure via the autophagy molecule Beclin-1 pathway

  Lin, H., Li, H. F., Chen, H-H., Lai, P. F., Juan, S-H., Chen, J. J. & Cheng, C. F., 2014, In: Molecular Pharmacology. 85, 5, p. 682-691 10 p.

  Research output: Contribution to journal › Article › peer-review
  35 Citations (Scopus)

• Activating transcription factor 3, an early cellular adaptive responder in ischemia/reperfusion-induced injury

  Lin, H. & Cheng, C. F., 2018, In: Tzu Chi Medical Journal. 30, 2, p. 61-65 5 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access
  7 Citations (Scopus)

• Activating the Wnt/β-catenin pathway did not protect immature retina from hypoxic-ischemic injury

  Huang, H. M., Huang, C. C., Wang, F. S., Hung, P. L. & Chang, Y. C., 2015, In: Investigative Ophthalmology and Visual Science. 56, 8, p. 4300-4308 9 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• Activating protein 1-mediated cyclooxygenase-2 expression is independent of N-terminal phosphorylation of c-Jun

  Chen, L. C., Chen, B. K. & Chang, W. C., Jun 2005, In: Molecular Pharmacology. 67, 6, p. 2057-2069 13 p.

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• Activating Inert ZnO by Surface Cobalt Doping for Efficient Water Oxidation in Neutral Media

  Meng, C., Gao, Y. F., Chen, X. M., Li, Y. X., Lin, M. C. & Zhou, Y., Nov 4 2019, In: ACS Sustainable Chemistry and Engineering. 7, 21, p. 18055-18060 6 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation

  Bjorge, J. D., Chan, T. O., Antczak, M., Kung, H. J. & Fujita, D. J., Jan 1 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 10, p. 3816-3820 5 p.

  Research output: Contribution to journal › Article › peer-review
  134 Citations (Scopus)

• Activated protein C improves heatstroke outcomes through restoration of normal hypothalamic and thermoregulatory function

  Chen, C. C., Chen, Z. C., Lin, M. T. & Hsu, C. C., Nov 2009, In: American Journal of the Medical Sciences. 338, 5, p. 382-387 6 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• Activated Protein C Decreases Alveolar Protein Leakage in an Animal Model of Ventilator-Induced Lung Injury

  Chen, C-M. & Wang, L-F., 2010, In: 中華民國兒童胸腔醫學會雜誌. 6, 4, p. 109-115 7 p.

  Research output: Contribution to journal › Article › peer-review

• Activated PAR-2 regulates pancreatic cancer progression through ILK/HIF-α-induced TGF-α expression and MEK/VEGF-a-mediated angiogenesis

  Chang, L. H., Pan, S. L., Lai, C. Y., Tsai, A. C. & Teng, C. M., Aug 2013, In: American Journal of Pathology. 183, 2, p. 566-575 10 p.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• Activated p300 acetyltransferase activity modulates aortic valvular calcification with osteogenic transdifferentiation and downregulation of Klotho

  Li, S. J., Kao, Y. H., Chung, C. C., Chen, W. Y., Cheng, W. L. & Chen, Y. J., Apr 1 2017, In: International Journal of Cardiology. 232, p. 271-279 9 p.

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)