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• A novel HDAC1/2 inhibitor suppresses colorectal cancer through apoptosis induction and cell cycle regulation

  Lee, H. Y., Tang, D. W., Liu, C. Y. & Cho, E. C., Jan 25 2022, In: Chemico-Biological Interactions. 352, 109778.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• A novel HA/β-TCP-collagen composite enhanced new bone formation for dental extraction socket preservation in beagle dogs

  Ho, K. N., Salamanca, E., Chang, K. C., Shih, T. C., Chang, Y. C., Huang, H. M., Teng, N. C., Lin, C. T., Feng, S-W. & Chang, W. J., Mar 11 2016, In: Materials. 9, 3, 191.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• A Novel Grid-based Platform for the Care of Taiwan's Lung Cancer Patients

  Shu-Hui, H., Chung-Chen, T., Shin-Hung, L., Jen-Hsin, C., Huang-Shen, C. & Wen-Te, L., 2008, Proceedings of the 2008 International Conference on Semantic Web and Web Services, SWWS 2008. p. 153-154 2 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• A novel global strain diastolic index correlates with plasma NT-proBNP levels in asymptomatic hypertensive patients with preserved left ventricular ejection fraction

  Chiang, S. J., Daimon, M., Ishii, K., Miyazaki, S., Koiso, Y., Suzuki, H., Miyauchi, K., Yang, B., Yeh, M. H., Hwang, B. & Daida, H., Jun 2012, In: Journal of Echocardiography. 10, 2, p. 56-64 9 p.

  Research output: Contribution to journal › Article › peer-review
  1 Citation (Scopus)

• A novel generalized item relational structure theory based on Liu’s normalization and consistency criteria

  Liu, H. C., Shia, B. C., Ju, J. M., Wang, T. L., Su, C. H. & Lin, Y. T., 2016, In: ICIC Express Letters. 10, 12, p. 2957-2962 6 p.

  Research output: Contribution to journal › Article › peer-review

• A novel function of the lysophosphatidic acid receptor 3 (LPAR3) gene in zebrafish on modulating anxiety, circadian rhythm locomotor activity, and short-term memory

  Lin, Y. N., Audira, G., Malhotra, N., Anh, N. T. N., Siregar, P., Lu, J. H., Lee, H. & Hsiao, C. D., Apr 2 2020, In: International journal of molecular sciences. 21, 8, 2837.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• A novel fucoidan complex-based functional beverage attenuates oral cancer through inducing apoptosis, G2/M cell cycle arrest and retarding cell migration/invasion

  Chen, P. H., Chiang, P. C., Lo, W. C., Su, C. W., Wu, C. Y., Chan, C. H., Wu, Y. C., Cheng, H. C., Deng, W. P., Lin, H. K. & Peng, B. Y., Oct 2021, In: Journal of Functional Foods. 85, 104665.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  4 Citations (Scopus)

• A novel follicle-stimulating hormone-induced Gαh/phospholipase C-δ1 signaling pathway mediating rat Sertoli cell Ca2+-influx

  Lin, Y. F., Tseng, M. J., Hsu, H. L., Wu, Y. W., Lee, Y-H. & Tsai, Y-H., 2006, In: Molecular Endocrinology. 20, 10, p. 2514-2527 14 p.

  Research output: Contribution to journal › Article › peer-review
  41 Citations (Scopus)

• A novel fibroblast growth factor-1 (FGF1) mutant that acts as an FGF antagonist

  Yamaji, S., Saegusa, J., Ieguchi, K., Fujita, M., Mori, S., Takada, Y. K. & Takada, Y., 2010, In: PLoS One. 5, 4, e10273.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• A novel fabrication method for the mold insert of microlens arrays by hot embossing molding

  Shen, Y. K., Dec 2006, In: Polymer Engineering and Science. 46, 12, p. 1797-1803 7 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• A novel fabrication method for mold insert of injection molded microlens array

  Shen, Y. K., 2006, Materials Science Forum. Vol. 532-533. p. 665-668 4 p. (Materials Science Forum; vol. 532-533).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  3 Citations (Scopus)

• A novel fabrication method and optimum tooling design for microlens arrays

  Shen, Y. K., Chang, C. Y., Shen, Y. S. & Yang, S. Y., 2006, Annual Technical Conference - ANTEC, Conference Proceedings. Vol. 5. p. 2571-2575 5 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  1 Citation (Scopus)

• A novel exon 15-deleted, splicing variant of Slit2 shows potential for growth inhibition in addition to invasion inhibition in lung cancer

  Lin, Y. Y., Yang, C. H., Sheu, G. T., Huang, C. Y. F., Wu, Y. C., Chuang, S. M., Fann, M. J., Chang, H., Lee, H. & Chang, J. T., Aug 1 2011, In: Cancer. 117, 15, p. 3404-3415 12 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• A novel electrospun Microtube Array Membrane (MTAM) based low cost conceptual tubular Microbial Fuel Cell (MFC)

  Chew, C. H., Wu, C. C. & Chen, C. C., Oct 1 2016, In: European Polymer Journal. 83, p. 138-147 10 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• A novel electrokinetic micromixer

  Wu, H. Y. & Liu, C. H., 2003, TRANSDUCERS 2003 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems, Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc., Vol. 1. p. 631-634 4 p. 1215552

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  9 Citations (Scopus)

• A novel electrokinetic micromixer

  Wu, H. Y. & Liu, C. H., Jan 31 2005, In: Sensors and Actuators, A: Physical. 118, 1, p. 107-115 9 p.

  Research output: Contribution to journal › Article › peer-review
  102 Citations (Scopus)

• A novel efficient Au-Ag alloy catalyst system: Preparation, activity, and characterization

  Wang, A. Q., Liu, J. H., Lin, S. D., Lin, T. S. & Mou, C. Y., Jul 1 2005, In: Journal of Catalysis. 233, 1, p. 186-197 12 p.

  Research output: Contribution to journal › Article › peer-review
  334 Citations (Scopus)

• A novel earplug system for filtering out dental noise

  Chang, J. R., Cheng, H. K., Lee, S. Y., Bai, M. R. & Lean, R. I., 2003, In: Journal of Marine Science and Technology. 11, 4, p. 179-188 10 p.

  Research output: Contribution to journal › Article › peer-review

• A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo

  Wu, Y. W., Chao, M. W., Tu, H. J., Chen, L. C., Hsu, K. C., Liou, J. P., Yang, C. R., Yen, S. C., HuangFu, W. C. & Pan, S. L., May 2021, In: Oncogenesis. 10, 5, 39.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  6 Citations (Scopus)

• A novel dual HDAC6 and tubulin inhibitor, MPT0B451, displays anti-tumor ability in human cancer cells in vitro and in vivo

  Wu, Y. W., Hsu, K. C., Lee, H. Y., Huang, T. C., Lin, T. E., Chen, Y. L., Sung, T. Y., Liou, J. P., Hwang-Verslues, W. W., Pan, S. L. & HuangFu, W. C., Mar 13 2018, In: Frontiers in Pharmacology. 9, MAR, 205.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  21 Citations (Scopus)

• A novel DNA structure induced by the anticancer bisplatinum compound crosslinked to a GpC site in DNA

  Yang, D., van Boom, S. S. G. E., Reedijk, J., van Boom, J. H., Farrell, N. & Wang, A. H. J., Jul 1995, In: Nature Structural Biology. 2, 7, p. 577-586 10 p.

  Research output: Contribution to journal › Article › peer-review
  67 Citations (Scopus)

• A novel detection platform for shrimp white spot syndrome virus using an ICP11-dependent immunomagnetic reduction (IMR) assay

  Liu, B. H., Lin, Y. C., Ho, C. S., Yang, C. C., Chang, Y. T., Chang, J. F., Li, C. Y., Cheng, C. S., Huang, J. Y., Lee, Y. F., Hsu, M. H., Lin, F. C., Wang, H. C., Lo, C. F., Yang, S. Y. & Wang, H. C., Sep 18 2015, In: PLoS One. 10, 9, e0138207.

  Research output: Contribution to journal › Article › peer-review
  9 Citations (Scopus)

• A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy

  Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C. & Hung, J. J., 2015, In: Oncotarget. 6, 15, p. 13671-13687 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  20 Citations (Scopus)

• A novel DEMATEL theory based on Liu's polytomous ordering theory

  Liu, H. C., Ou, Y. C., Shia, B. C. & Tsai, H. C., Aug 2 2016, In: Unknown Journal. 71, 01001.

  Research output: Contribution to journal › Article › peer-review

• A novel defensin encoded by a mungbean cDNA exhibits insecticidal activity against bruchid

  Chen, K. C., Lin, C. Y., Kuan, C. C., Sung, H. Y. & Chen, C. S., Dec 4 2002, In: Journal of Agricultural and Food Chemistry. 50, 25, p. 7258-7263 6 p.

  Research output: Contribution to journal › Article › peer-review
  82 Citations (Scopus)

• A novel core fractionation process of human plasma by expanded bed adsorption chromatography

  Lihme, A., Hansen, M. B., Andersen, I. V. & Burnouf, T., Apr 2010, In: Analytical Biochemistry. 399, 1, p. 102-109 8 p.

  Research output: Contribution to journal › Article › peer-review
  27 Citations (Scopus)

• A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo

  Chen, Y. W., Huang, H. S., Shieh, Y. S., Ma, K. H., Huang, S. H., Hueng, D. Y., Sytwu, H. K. & Lin, G. J., Aug 15 2014, In: PLoS ONE. 9, 8, e104703.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  7 Citations (Scopus)

• A novel compound heterozygous mutation of K494_V495 deletion plus R496L and D487_F489 deletion in extreme C-terminus of cytochrome P450c17 causes 17α-hydroxylase deficiency

  Lee, L. S., Shu, W. J., Wu, C. M., Hsieh, C. H., Chen, S. M., Hu, C. J., Chen, W. Y. & Chung, B. C., Apr 25 2006, In: Molecular and Cellular Endocrinology. 249, 1-2, p. 16-20 5 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• A novel composite hydrogel composed of formic acid-decellularized pepsin-soluble extracellular matrix hydrogel and sacchachitin hydrogel as wound dressing to synergistically accelerate diabetic wound healing

  Hsieh, C. M., Wang, W., Chen, Y. H., Wei, P. S., Liu, Y. H., Sheu, M. T. & Ho, H. O., Jun 11 2020, In: Pharmaceutics. 12, 6, p. 1-18 18 p., 538.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  12 Citations (Scopus)

• A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

  Wang, L. T., Liou, J. P., Li, Y. H., Liu, Y. M., Pan, S. L. & Teng, C. M., 2014, In: Oncotarget. 5, 14, p. 5651-5662 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  30 Citations (Scopus)

• A novel chromosomal abnormality involving 2q37 in myeloid malignancies [1]

  Chen, C. C., Lee, K. D., Yang, C. F. & Gau, J. P., May 2006, In: Annals of Hematology. 85, 5, p. 333-334 2 p.

  Research output: Contribution to journal › Letter › peer-review

• A novel cell-based therapy for contusion spinal cord injury using GDNF-delivering NIH3T3 cells with dual reporter genes monitored by molecular imaging

  Lo, W. C., Hsu, C. H., Wu, A. T. H., Yang, L. Y., Chen, W. H., Chiu, W. T., Lai, W-F., Wu, C. H., Gelovani, J. G. & Deng, W. P., Sep 1 2008, In: Journal of Nuclear Medicine. 49, 9, p. 1512-1519 8 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• A novel cationic cardiolipin analogue for gene delivery

  Zhang, Z. Y., Ugwu, S., Zhang, A., Ahmad, M. U., Ahmad, I., Chiu, S. & Lee, R. L., Jan 2006, In: Pharmazie. 61, 1, p. 10-14 5 p.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• A novel cancer therapeutic using thrombospondin 1 in dendritic cells

  Weng, T. Y., Huang, S. S., Yen, M. C., Lin, C. C., Chen, Y. L., Lin, C. M., Chen, W. C., Wang, C. Y., Chang, J. Y. & Lai, M. D., Jan 1 2014, In: Molecular Therapy. 22, 2, p. 292-302 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  25 Citations (Scopus)

• A novel calcium-independent enzyme capable of incorporating putrescine into proteins

  Tsai, Y. H., Lai, W. F. T., Chen, S. H. & Johnson, L. R., Mar 6 1998, In: Biochemical and Biophysical Research Communications. 244, 1, p. 161-166 6 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• A novel bubble-mixture method to improve dynamic images in carbon dioxide angiography

  Chang, T. I., Chan, C. Y., Su, S. K., Wang, S. S. & Wu, I. H., Aug 1 2015, In: Journal of Endovascular Therapy. 22, 4, p. 564-567 4 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells

  Juang, S. H., Pan, W. Y., Kuo, C. C., Liou, J. P., Hung, Y. M., Chen, L. T., Hsieh, H. P. & Chang, J. Y., Jul 15 2004, In: Biochemical Pharmacology. 68, 2, p. 293-303 11 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• A novel biological computation method for deriving and resolving discernibility relations

  Kim, I., Watada, J., Wu, J. Y. & Chu, Y. Y., 2009, Proceedings of the 2009 9th IEEE International Conference on Bioinformatics and BioEngineering, BIBE 2009. p. 9-14 6 p. 5211339

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis

  Yen, T. L., Hsu, W. H., Huang, S. K. H., Lu, W-J., Chang, C. C., Lien, L. M., Hsiao, G., Sheu, J. R. & Lin, K. H., Sep 2013, In: Pharmaceutical Biology. 51, 9, p. 1150-1157 8 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• A novel approach to quantitatively assess the uniformity of binary colloidal crystal assemblies

  Koegler, P., Dunn, M., Wang, P. Y., Thissen, H. & Kingshott, P., Aug 1 2016, In: Crystals. 6, 8, 84.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• A Novel Approach to Fabricate Silicon Nanowire Field Effect Transistor for Biomolecule Sensing

  Wu, C. C., Manga, Y. B., Hung, J. Y. & Yang, W. L., 2018, AETA 2017 - Recent Advances in Electrical Engineering and Related Sciences - Theory and Application. Kim, S. B., Dao, T. T., Zelinka, I., Duy, V. H. & Phuong, T. T. (eds.). Springer Verlag, p. 250-257 8 p. (Lecture Notes in Electrical Engineering; vol. 465).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

• A novel approach for prediction of multi-labeled protein subcellular localization for prokaryotic bacteria

  Su, C. Y., Lo, A., Lin, C. C., Chang, F. & Hsu, W. L., 2005, 2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts. p. 79-80 2 p. 1540549

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  7 Citations (Scopus)

• A novel approach for discovering condition-specific correlations of gene expressions within biological pathways by using cloud computing technology

  Chang, T. H., Wu, S. L., Wang, W. J., Horng, J. T. & Chang, C. W., 2014, In: BioMed Research International. 2014, 763237.

  Research output: Contribution to journal › Article › peer-review
  3 Citations (Scopus)

• A novel approach: Simulating multiple simultaneous encounters to assess multitasking ability in emergency medicine

  Huang, W. C., Hsu, S. C., Yang, C. H., Lin, C. W., Suk, F. M., Hu, K. C., Wu, Y. Y., Chen, H. Y. & Hsu, C. W., Sep 2021, In: PLoS ONE. 16, 9 September, e0257887.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• A novel application of E1A in combination therapy with EGFR- TKI treatment in breast cancer

  Su, C. M., Chang, T. Y., Hsu, H. P., Lai, H. H., Li, J. N., Lyu, Y. J., Kuo, K. T., Huang, M. T., Su, J. L. & Chen, P. S., 2016, In: Oncotarget. 7, 39, p. 63924-63936 13 p.

  Research output: Contribution to journal › Article › peer-review
  8 Citations (Scopus)

• A novel application of acoustic plate mode sensor in tissue regeneration

  Pan, L. C., Liang, Y. C., Tseng, F. G., Leou, K. C., Chen, L. D. & Lai, Y. Y., 2002, Proceedings of the IEEE-EMBS Special Topic Conference on Molecular, Cellular and Tissue Engineering, MCTE 2002. Institute of Electrical and Electronics Engineers Inc., p. 143-144 2 p. 1175045

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
  6 Citations (Scopus)

• A novel anti-tumor/anti-tumor-associated fibroblast/anti-mPEG tri-specific antibody to maximize the efficacy of mPEGylated nanomedicines against fibroblast-rich solid tumor

  Chen, M., Sheu, M. T., Cheng, T. L., Roffler, S. R., Lin, S. Y., Chen, Y. J., Cheng, Y. A., Cheng, J. J., Chang, H. Y., Wu, T. Y., Kao, A. P., Ho, Y. S. & Chuang, K. H., Jan 7 2022, In: Biomaterials Science. 10, 1, p. 202-215 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Citations (Scopus)

• A novel antithrombotic effect of sulforaphane via activation of platelet adenylate cyclase: Ex vivo and in vivo studies

  Jayakumar, T., Chen, W. F., Lu, W-J., Chou, D. S., Hsiao, G., Hsu, C-Y., Sheu, J. R. & Hsieh, C. Y., Jun 2013, In: Journal of Nutritional Biochemistry. 24, 6, p. 1086-1095 10 p.

  Research output: Contribution to journal › Article › peer-review
  36 Citations (Scopus)

• A novel antioxidant, octyl caffeate, suppression of LPS/IFN-γ-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells

  Hsiao, G., Shen, M. Y., Chang, W. C., Cheng, Y. W., Pan, S. L., Kuo, Y. H., Chen, T. F. & Sheu, J. R., Apr 15 2003, In: Biochemical Pharmacology. 65, 8, p. 1383-1392 10 p.

  Research output: Contribution to journal › Article › peer-review
  23 Citations (Scopus)

• A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth

  Guo, Z., Yang, X., Sun, F., Jiang, R., Linn, D. E., Chen, H., Chen, H., Kong, X., Melamed, J., Tepper, C. G., Kung, H. J., Brodie, A. M. H., Edwards, J. & Qiu, Y., Mar 15 2009, In: Cancer Research. 69, 6, p. 2305-2313 9 p.

  Research output: Contribution to journal › Article › peer-review
  697 Citations (Scopus)