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Topoisomerase I and II inhibitors: A patent review

Singh, A., Kaur, N., Singh, G., Sharma, P., Bedi, P. M. S., Sharma, S. & Nepali, K., Nov 1 2016, In : Recent Patents on Anti-Cancer Drug Discovery. 11, 4, p. 401-423 23 p.

Research output: Contribution to journalReview article

7 Citations (Scopus)

Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells

Li, Y., Hao, H., Tzatzalos, E., Lin, R. K., Doh, S., Liu, L-F., Lyu, Y. L. L. & Cai, L., Feb 15 2014, In : Biology Open. 3, 2, p. 172-184 13 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

Topoisomerase II is a structural component of mitotic chromosome scaffolds

Earnshaw, W. C., Halligan, B., Cooke, C. A., Heck, M. M. S. & Liu, L-F., May 1 1985, In : Journal of Cell Biology. 100, 5, p. 1706-1715 10 p.

Research output: Contribution to journalArticle

573 Citations (Scopus)

Topoisomerase II-mediated DNA cleavage and mutagenesis activated by nitric oxide underlie the inflammation-associated tumorigenesis

Yang, Y-C., Chou, H-Y. E., Shen, T-L., Chang, W-J., Tai, P-H. & Li, T-K., 2013, In : Antioxidants and Redox Signaling. 18, 10, p. 1129-1140 12 p.

Research output: Contribution to journalArticle

16 Citations (Scopus)

Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs

Hsiang, W. H., Jiang, J. B. & Liu, L-F., 1989, In : Molecular Pharmacology. 36, 3, p. 371-376 6 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

Topoisomerase I inhibition and cytotoxicity of 5-bromo- and 5-phenylterbenzimidazoles

Rangarajan, M., Kim, J. S., Sim, S. P., Liu, A., Liu, L-F. & LaVoie, E. J., 2000, In : Bioorganic and Medicinal Chemistry. 8, 11, p. 2591-2600 10 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Topoisomerase i inhibitor evodiamine acts as an antibacterial agent against drug-resistant Klebsiella pneumoniae

Wu, J. Y., Chang, M. C., Chen, C. S., Lin, H. C., Tsai, H. P., Yang, C. C., Yang, C. H. & Lin, C. M., 2013, In : Planta Medica. 79, 1, p. 27-29 3 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)

Topoisomerase I inhibitor suppress tumor growth in chemoresistant ovarian cancer-initiating cells

Wang, Y. C., Chang, C. C., Chiang, K. J., Chao, T. K., Wu, C. C., Chang, P. Y., Wu, C. C. & Lai, H. C., 2014, In : Journal of Medical Sciences (Taiwan). 34, 2, p. 72-76 5 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Topoisomerase IIβ deficiency enhances camptothecin-induced apoptosis

Lin, R. K., Ho, C. W., Liu, L-F. & Lyu, Y. L., Mar 8 2013, In : Journal of Biological Chemistry. 288, 10, p. 7182-7192 11 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Topoisomerase IIβ-mediated DNA double-strand breaks: Implications in doxorubicin cardiotoxicity and prevention by dexrazoxane

Yi, L. L., Kerrigan, J. E., Lin, C. P., Azarova, A. M., Tsai, Y. C., Ban, Y. & Liu, L. F., Sep 15 2007, In : Cancer Research. 67, 18, p. 8839-8846 8 p.

Research output: Contribution to journalArticle

347 Citations (Scopus)

Topoisomerase I-targeting drugs. New developments in cancer pharmacology

Gatto, B. & Liu, L-F., 1998, In : Advances in DNA Sequence-Specific Agents. 3, C, p. 39-66 28 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Topoisomerase IV is required for partitioning of circular chromosomes but not linear chromosomes in streptomyces

Huang, T-W., Hsu, C., Yang, H. & Chen, C. W., 2013, In : Nucleic Acids Research. 41, 22, p. 10403-10413 11 p.

Research output: Contribution to journalArticle

4 Citations (Scopus)

Topoisomerases: Novel therapeutic targets in cancer chemotherapy

Hsiang, Y. H., Wu, H. Y. & Liu, L-F., May 1 1988, In : Biochemical Pharmacology. 37, 9, p. 1801-1802 2 p.

Research output: Contribution to journalArticle

40 Citations (Scopus)

Topoisomerases as novel targets for cancer chemotherapy

Bodley, A. L. & Liu, L-F., 1988, In : Bio/Technology. 6, 11, p. 1315-1319 5 p.

Research output: Contribution to journalArticle

57 Citations (Scopus)

Topoisomerase-targeting antitumor drugs

D'Arpa, P. & Liu, L-F., Dec 17 1989, In : BBA - Reviews on Cancer. 989, 2, p. 163-177 15 p.

Research output: Contribution to journalArticle

508 Citations (Scopus)

Topoisomerase-targeting antitumor drugs: mechanisms of cytotoxicity and resistance.

Liu, L-F. & D'Arpa, P., 1992, In : Important advances in oncology. p. 79-89 11 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Topological approaches to studies of protein-mediated looping of DNA in vivo

Wu, H. Y. & Liu, L-F., 1992, In : Methods in Enzymology. 212, p. 346-351 6 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

Rajendra, R., Malegaonkar, D., Pungaliya, P., Marshall, H., Rasheed, Z., Brownell, J., Liu, L-F., Lutzker, S., Saleem, A. & Rubin, E. H., Aug 27 2004, In : Journal of Biological Chemistry. 279, 35, p. 36440-36444 5 p.

Research output: Contribution to journalArticle

145 Citations (Scopus)

Top-Ten Pitfalls When Imaging Osteoporosis

Cheng, X., Griffith, J. F. & Chan, W. P., Jan 1 2019, In : Seminars in Musculoskeletal Radiology. 23, 4, p. 453-464 12 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

TOR regulates cell death induced by telomere dysfunction in budding yeast

Qi, H., Chen, Y., Fu, X., Lin, C. P., Zheng, X. F. S. & Liu, L-F., Oct 24 2008, In : PLoS One. 3, 10, e3520.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Total anomalous pulmonary venous return complicated by progressive pulmonary venous stenosis after total repair: Report of one case

Chang, J. S., Lai, Y. C., Li, P. C. & Chen, C. L., Sep 2002, In : Acta Paediatrica Taiwanica. 43, 5, p. 276-280 5 p.

Research output: Contribution to journalArticle

Total antioxidant status and nitric oxide do not increase in peritoneal fluids from women with endometriosis

Ho, H. N., Wu, M. Y., Chen, S. U., Chao, K. H., Chen, C. D. & Yang, Y. S., Jan 1 1997, In : Human Reproduction. 12, 12, p. 2810-2815 6 p.

Research output: Contribution to journalArticle

Open Access
73 Citations (Scopus)
1 Citation (Scopus)

Total creatinine appearance as indicator of risk of infectious complication in peritoneal dialysis.

Wu, C. H., Huang, C. C., Wu, M. S., Yang, C. W., Huang, J. Y., Fang, J. T. & Leu, M. L., 2000, In : Advances in peritoneal dialysis. Conference on Peritoneal Dialysis. 16, p. 219-222 4 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)
7 Citations (Scopus)

Total knee anthroplasty: Patella resurfacing versus nonresurfacing

Hsu, R. W. W., Tsai, Y. H., Huang, T. J. & Chang, J. C. C., 1998, In : Journal of Musculoskeletal Research. 2, 4, p. 297-306 10 p.

Research output: Contribution to journalArticle

Total laparoscopic radical hysterectomy and pelvic lymphadenectomy in locally advanced stage IB2-IIB cervical cancer patients after neoadjuvant chemotherapy

Vizza, E., Pellegrino, A., Milani, R., Fruscio, R., Baiocco, E., Cognetti, F., Savarese, A., Tomao, F., Chen, C. & Corrado, G., Apr 1 2011, In : European Journal of Surgical Oncology. 37, 4, p. 364-369 6 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Total lesion glycolysis determined per RECIST 1.1 criteria predicts survival in EGFR mutation-negative patients with advanced lung adenocarcinoma

Ho, T. Y., Chou, P. C., Yang, C. T., Tsang, N. M. & Yen, T. C., Jun 25 2015, In : Clinical Nuclear Medicine. 40, 6, p. e295-e299

Research output: Contribution to journalArticle

9 Citations (Scopus)

Totally Endoscopic Coronary Artery Bypass for Anomalous Origin of Right Coronary Artery

Kuo, C. C., Hsing, C. H. & Cheng, B. C., Jan 1 2017, In : Annals of Thoracic Surgery. 103, 1, p. e35-e37

Research output: Contribution to journalArticle

2 Citations (Scopus)

Totally laparoscopic radical bii gastrectomy for the treatment of gastric cancer: A comparison with open surgery

Lee, W. J., Wang, W., Chen, T. C., Chen, J. C. & Ser, K. H., Aug 2008, In : Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 18, 4, p. 369-374 6 p.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Total pelvic exenteration for primary local advanced colorectal cancer

Chen, H. S. & Sheen-Chen, S. M., Dec 1 2001, In : World Journal of Surgery. 25, 12, p. 1546-1549 4 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

Total sleep deprivation augments balloon angioplasty-induced neointimal hyperplasia in rats

Wu, R. S. C., Huang, C. C., Pan, C. H., Wu, K. C., Chen, C. C., Liu, S. K., Tang, C. L. & Wu, C. H., Nov 2011, In : Experimental Physiology. 96, 11, p. 1239-1247 9 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Total sleep deprivation inhibits the neuronal nitric oxide synthase and cytochrome oxidase reactivities in the nodose ganglion of adult rats

Chang, H. M., Wu, U. I., Lin, T. B., Lan, C. T., Chien, W. C., Huang, W. L. & Shieh, J. Y., Aug 2006, In : Journal of Anatomy. 209, 2, p. 239-250 12 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

Total synthesis and metabolic stability of hispidulin and its d-labelled derivative

Chen, L. C., Hsu, K. C., Chiou, L. C., Tseng, H. J. & Huang, W. J., Nov 1 2017, In : Molecules. 22, 11, 1897.

Research output: Contribution to journalArticle

2 Citations (Scopus)

Total synthesis of (±)-desoxycodeine-D: A novel route to the morphine skeleton

Liou, J. P. & Cheng, C. Y., Feb 5 2000, In : Tetrahedron Letters. 41, 6, p. 915-918 4 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

Total Synthesis of Denbinobin

Lee, H. Y., Kumar, S., Lin, T. C. & Liou, J. P., Apr 22 2016, In : Journal of Natural Products. 79, 4, p. 1170-1173 4 p.

Research output: Contribution to journalArticle

7 Citations (Scopus)

Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1

Chao, S. W., Su, M. Y., Chiou, L. C., Chen, L. C., Chang, C. I. & Huang, W. J., Aug 28 2015, In : Journal of Natural Products. 78, 8, p. 1969-1976 8 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Total synthesis of homogeneous variants of hirudin P6: A post-translationally modified anti-thrombotic leech-derived protein

Hsieh, Y. S. Y., Wijeyewickrema, L. C., Wilkinson, B. L., Pike, R. N. & Payne, R. J., Apr 7 2014, In : Angewandte Chemie - International Edition. 53, 15, p. 3947-3951 5 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Total synthesis of NADH: ubiquinone oxidoreductase (complex I) antagonist pterulone and its analogue

Huang, S. T., Kuo, H. S. & Chen, C. T., Oct 15 2001, In : Tetrahedron Letters. 42, 42, p. 7473-7475 3 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
3 Citations (Scopus)

To the editor

Burnouf, T., Conton, B. & Dye, J. M., Jun 23 2016, In : New England Journal of Medicine. 374, 25, p. 2499 1 p.

Research output: Contribution to journalLetter

To the editor

Chiu, W. T. & Laporte, R. E., 1993, In : Journal of Trauma - Injury, Infection and Critical Care. 35, 6, p. 970 1 p.

Research output: Contribution to journalArticle

Touch-screen-guided task reveals a prosocial choice tendency by chimpanzees (Pan troglodytes)

Mendonça, R. S., Dahl, C. D., Carvalho, S., Matsuzawa, T. & Adachi, I., Jul 31 2018, In : PeerJ. 2018, 7, e5315.

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

To use or not to use? Compulsive behavior and its role in smartphone addiction

Lin, Y-H., Lin, Y-C., Lin, S-H., Lee, Y-H., Lin, P-H., Chiang, C. L., Chang, L. R., Yang, C. C. H. & Kuo, T. B. J., Feb 14 2017, In : Translational Psychiatry. 7, 2, p. e1030

Research output: Contribution to journalArticle

19 Citations (Scopus)

Tousled-like kinases stabilize replication forks and show synthetic lethality with checkpoint and PARP inhibitors

Lee, S. B., Segura-Bayona, S., Villamor-Payà, M., Saredi, G., Todd, M. A. M., Attolini, C. S. O., Chang, T. Y., Stracker, T. H. & Groth, A., Aug 8 2018, In : Science advances. 4, 8, eaat4985.

Research output: Contribution to journalArticle

11 Citations (Scopus)

Toward accurate solvation dynamics of lanthanides and actinides in water using polarizable force fields: From gas-phase energetics to hydration free energies

Marjolin, A., Gourlaouen, C., Clavaguéra, C., Ren, P. Y., Wu, J. C., Gresh, N., Dognon, J. P. & Piquemal, J. P., May 3 2012, In : Theoretical Chemistry Accounts. 131, 4, p. 1-14 14 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)

Toward a functional near-infrared spectroscopy-based monitoring of pain assessment for nonverbal patients

Fernandez Rojas, R., Huang, X. & Ou, K. L., Oct 1 2017, In : Journal of Biomedical Optics. 22, 10, 106013.

Research output: Contribution to journalArticle

8 Citations (Scopus)

Toward an explanatory framework for mental ownership

Lane, T., Jun 2012, In : Phenomenology and the Cognitive Sciences. 11, 2, p. 251-286 36 p.

Research output: Contribution to journalArticle

19 Citations (Scopus)