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Article
17 Citations (Scopus)

Activation of estrogen receptors with E2 downregulates peroxisome proliferator-activated receptor γ in hepatocellular carcinoma

Lin, Y. M., Velmurugan, B. K., Yeh, Y. L., Tu, C. C., Ho, T. J., Lai, T-I., Tsai, C. H., Tsai, F. J., Tsai, C. H. & Huang, C. Y., Dec 2013, In : Oncology Reports. 30, 6, p. 3027-3031 5 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Estrogen Receptors
Hepatocellular Carcinoma
Down-Regulation
Liver Neoplasms
38 Citations (Scopus)

Activation of extracellular signal-regulated kinase (ERK)1/2, but not p38 and c-Jun N-terminal kinase, is involved in signaling of a novel cytokine, ML-1

Kawaguchi, M., Onuchic, L. F. & Huang, S. K., May 3 2002, In : Journal of Biological Chemistry. 277, 18, p. 15229-15232 4 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinase 3
Interleukin-17
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 1
Interleukin-8
33 Citations (Scopus)
Keratin-16
Extracellular Signal-Regulated MAP Kinases
Epidermal Growth Factor
Gene Expression
Acetylation
11 Citations (Scopus)

Activation of fibroblast growth factor 8 gene expression in human embryonal carcinoma cells

Wu, J., Payson, R. A., Lang, J. C. & Chiu, I. M., May 1997, In : Journal of Steroid Biochemistry and Molecular Biology. 62, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factor 8
Embryonal Carcinoma Stem Cells
Gene expression
Chemical activation
Cells
5 Citations (Scopus)

Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells

Chen, P. C., Lee, W. Y., Ling, H. H., Cheng, C. H., Chen, K. C. & Lin, C. W., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Fibroblasts
Nicotine
Chemical activation
Cells
8 Citations (Scopus)

Activation of free fatty acid receptor 1 improves hepatic steatosis through a p38-dependent pathway

Ou, H. Y., Wu, H. T., Lu, F. H., Su, Y. C., Hung, H. C., Wu, J. S., Yang, Y. C., Wu, C. L. & Chang, C. J., Jul 9 2014, In : Journal of Molecular Endocrinology. 53, 2, p. 165-174 10 p.

Research output: Contribution to journalArticle

Nonesterified Fatty Acids
Liver
Hep G2 Cells
High Fat Diet
Sterol Regulatory Element Binding Protein 1
25 Citations (Scopus)

Activation of gonadotropin-releasing hormone receptors produces neuronal excitation in the rat hippocampus

Lu, F., Yang, J. M., Wu, J. N., Chen, Y. C., Kao, Y. H., Tung, C. S. & Yang, S. N., 1999, In : Chinese Journal of Physiology. 42, 2, p. 67-71 5 p.

Research output: Contribution to journalArticle

LHRH Receptors
Pyramidal Cells
Hippocampus
Evoked Potentials
Action Potentials
155 Citations (Scopus)
Prostaglandin Endoperoxides
Graves Ophthalmopathy
Hyaluronic Acid
Cyclooxygenase 2
Fibroblasts
54 Citations (Scopus)

Activation of human telomerase reverse transcriptase expression by some new symmetrical bis-substituted derivatives of the anthraquinone

Huang, H. S., Chiou, J. F., Fong, Y., Hou, C. C., Lu, Y. C., Wang, J. Y., Shih, J. W., Pan, Y. R. & Lin, J. J., Jul 17 2003, In : Journal of Medicinal Chemistry. 46, 15, p. 3300-3307 8 p.

Research output: Contribution to journalArticle

Anthraquinones
Telomerase
Chemical activation
Stem cells
Alkaline Phosphatase
1 Citation (Scopus)

Activation of IGF-I survival signaling and its compensative inhibition of the cardiac apoptosis on carotid arteries balloon-injured rat hearts

Hsieh, C. H., Pai, P., Wu, J. P., Ho, T. J., Wu, C. H., Shibu, M. A., Day, C. H., Viswanadha, V. P., Chuang, H. L. & Huang, C. Y., 2017, In : Chinese Journal of Physiology. 60, 3, p. 166-173 8 p.

Research output: Contribution to journalArticle

Insulin-Like Growth Factor I
Carotid Arteries
Apoptosis
Wounds and Injuries
Hypertrophy
49 Citations (Scopus)

Activation of IL6/IGFIR confers poor prognosis of HBV-related hepatocellular carcinoma through induction of OCT4/NANOG expression

Chang, T. S., Wu, Y. C., Chi, C. C., Su, W. C., Chang, P. J., Lee, K. F., Tung, T. H., Wang, J., Liu, J-J., Tung, S. Y., Kuo, L. M., Ho, H. N., Ling, T. Y. & Huang, Y-H., Jan 1 2015, In : Clinical Cancer Research. 21, 1, p. 201-210 10 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Hepatitis B virus
Hepatocellular Carcinoma
Interleukin-6
RNA Interference
24 Citations (Scopus)

Activation of imidazoline I2B receptors is linked with AMP kinase pathway to increase glucose uptake in cultured C2C12 cells

Lui, T. N., Tsao, C. W., Huang, S. Y., Chang, C. H. & Cheng, J. T., May 2010, In : Neuroscience Letters. 474, 3, p. 144-147 4 p.

Research output: Contribution to journalArticle

Imidazoline Receptors
Adenylate Kinase
Guanidine
Cultured Cells
Glucose
98 Citations (Scopus)

Activation of indices of cell-mediated immunity in bipolar mania

Tsai, S. Y., Chen, K. P., Yang, Y. Y., Chen, C. C., Lee, J. C., Singh, V. K. & Leu, S. J. C., Apr 15 1999, In : Biological Psychiatry. 45, 8, p. 989-994 6 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Cellular Immunity
Phytohemagglutinins
Lymphocytes
Pokeweed Mitogens
28 Citations (Scopus)

Activation of iodosobenzene by catalytic tetrabutylammonium iodide and its application in the oxidation of some isoquinoline alkaloids

Huang, W. J., Singh, O. V., Chen, C. H., Chiou, S. Y. & Lee, S. S., 2002, In : Helvetica Chimica Acta. 85, 4, p. 1069-1078 10 p.

Research output: Contribution to journalArticle

Isoquinolines
Tetrahydroisoquinolines
Berberine
Lactams
Alkaloids
42 Citations (Scopus)

Activation of JNK contributes to evodiamine-induced apoptosis and G 2/M arrest in human colorectal carcinoma cells: A structure-activity study of evodiamine

Chien, C. C., Wu, M. S., Shen, S. C., Ko, C. H., Chen, C. H., Yang, L. L. & Chen, Y. C., Jun 24 2014, In : PLoS One. 9, 6, e99729.

Research output: Contribution to journalArticle

HT29 Cells
colorectal neoplasms
Colorectal Neoplasms
phosphotransferases (kinases)
Phosphotransferases

Activation of MEK2 is sufficient to induce skin papilloma formation in transgenic zebrafish Application of Zebrafish in Biomedical Research

Chou, C. M., Chen, Y. C., Su, S., Chen, G. D., Huang, K. Y., Lien, H. W., Huang, C. J. & Cheng, C. H., Nov 17 2015, In : Journal of Biomedical Science. 22, 1, 102.

Research output: Contribution to journalArticle

Papilloma
Zebrafish
Biomedical Research
Skin
Chemical activation
34 Citations (Scopus)

Activation of mitogen-activated protein kinase by oxidized low-density lipoprotein in canine cultured vascular smooth muscle cells

Yang, C. M., Chiu, C. T., Wang, C. C., Chien, C. S., Hsiao, L. D., Lin, C. C., Tu, M. T. & Pan, S. L., Apr 2000, In : Cellular Signalling. 12, 4, p. 205-214 10 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Vascular Smooth Muscle
Smooth Muscle Myocytes
Canidae
Mitogen-Activated Protein Kinase 1
22 Citations (Scopus)

Activation of muscarinic M-3 receptor may decrease glucose uptake and lipolysis in adipose tissue of rats

Yang, T. T., Chang, C. K., Tsao, C. W., Hsu, Y. M., Hsu, C. T. & Cheng, J. T., Feb 13 2009, In : Neuroscience Letters. 451, 1, p. 57-59 3 p.

Research output: Contribution to journalArticle

Lipolysis
Cholinergic Agents
Adipose Tissue
Acetylcholine
Glucose
23 Citations (Scopus)

Activation of NF-κB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKβ expression

Chen, P. M., Wu, T. C., Wang, Y. C., Cheng, Y. W., Sheu, G. T., Chen, C. Y. & Lee, H., Nov 2013, In : Carcinogenesis. 34, 11, p. 2655-2663 9 p.

Research output: Contribution to journalArticle

Messenger RNA
Neoplasms
Lung
Epithelial-Mesenchymal Transition
Survival
20 Citations (Scopus)
Porphyromonas gingivalis
Heme Oxygenase-1
Lipopolysaccharides
Anti-Inflammatory Agents
Macrophages
18 Citations (Scopus)

Activation of Nrf2 by the dengue virus causes an increase in CLEC5A, which enhances TNF-α production by mononuclear phagocytes

Cheng, Y. L., Lin, Y. S., Chen, C. L., Tsai, T. T., Tsai, C. C., Wu, Y. W., Ou, Y. D., Chu, Y. Y., Wang, J. M., Yu, C. Y. & Lin, C. F., Aug 26 2016, In : Scientific Reports. 6, 32000.

Research output: Contribution to journalArticle

Dengue Virus
Phagocytes
Tumor Necrosis Factor-alpha
Virus Diseases
Toll-Like Receptor 3
27 Citations (Scopus)

Activation of opioid μ-receptor by sinomenine in cell and mice

Wang, M. H., Chang, C. K., Cheng, J. H., Wu, H. T., Li, Y. X. & Cheng, J. T., Oct 10 2008, In : Neuroscience Letters. 443, 3, p. 209-212 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Sinomenium
Naloxone
Cricetulus
sinomenine
21 Citations (Scopus)

Activation of p38 MAPK-regulated Bcl-xL signaling increases survival against zoledronic acid-induced apoptosis in osteoclast precursors

Tai, T. W., Su, F. C., Chen, C. Y., Jou, I. M. & Lin, C. F., 2014, In : Bone. 67, p. 166-174 9 p.

Research output: Contribution to journalArticle

zoledronic acid
p38 Mitogen-Activated Protein Kinases
Osteoclasts
Apoptosis
Survival
91 Citations (Scopus)

Activation of p38 mitogen-activated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia

Wen, Y-R., Suter, M. R., Ji, R. R., Yeh, G. C., Wu, Y. S., Wang, K. C., Kohno, T., Sun, W. Z. & Wang, C. C., Jan 2009, In : Anesthesiology. 110, 1, p. 155-165 11 p.

Research output: Contribution to journalArticle

Hyperalgesia
Microglia
p38 Mitogen-Activated Protein Kinases
Phosphorylation
Hot Temperature
4 Citations (Scopus)
Neoplasms
Apoptosis
Lung Neoplasms
Proteins
Epithelial-Mesenchymal Transition
Curcumin
Endothelin-1
Fibroblasts
Thrombin
Phosphotransferases
25 Citations (Scopus)

Activation of phosphodiesterase IV during desensitization of the A(2A) adenosine receptor-mediated cyclic AMP response in rat pheochromocytoma (PC12) cells

Chang, Y. H., Conti, M., Lee, Y. C., Lai, H. L., Ching, Y. H. & Chern, Y., Sep 1997, In : Journal of Neurochemistry. 69, 3, p. 1300-1309 10 p.

Research output: Contribution to journalArticle

Type 4 Cyclic Nucleotide Phosphodiesterase
Adenosine A2A Receptors
PC12 Cells
Pheochromocytoma
Cyclic AMP
28 Citations (Scopus)

Activation of ROS/NF-κB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1β-treated human tracheal smooth muscle cells

Luo, S. F., Chang, C. C., Lee, I-T., Lee, C. W., Lin, W. N., Lin, C. C. & Yang, C. M., May 15 2009, In : Toxicology and Applied Pharmacology. 237, 1, p. 8-21 14 p.

Research output: Contribution to journalArticle

calmidazolium
Vascular Cell Adhesion Molecule-1
Interleukin-1
Smooth Muscle Myocytes
Muscle
53 Citations (Scopus)

Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1

Chang, L. K., Chung, J. Y., Hong, Y. R., Ichimura, T., Nakao, M. & Liu, S. T., 2005, In : Nucleic Acids Research. 33, 20, p. 6528-6539 12 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Chromatin
Response Elements
Transcriptional Activation
snRNP Core Proteins
9 Citations (Scopus)

Activation of telomerase and cyclooxygenase-2 in PDGF and FGF inhibition of C2-ceramide-induced apoptosis

Chien, C. C., Shen, S. C., Yang, L. Y., Wu, C. Y., Liau, J. S. & Chen, Y. C., Feb 2009, In : Journal of Cellular Physiology. 218, 2, p. 405-415 11 p.

Research output: Contribution to journalArticle

Telomerase
Platelet-Derived Growth Factor
Cyclooxygenase 2
Chemical activation
Fibroblast Growth Factor 2
35 Citations (Scopus)

Activation of the calcineurin-nuclear factor of activated T-cell signal transduction pathway in atrial fibrillation

Lin, C. C., Lin, J. L., Lin, C. S., Tsai, M. C., Su, M. J., Lai, L. P. & Stephen Huang, S. K., Jan 1 2004, In : Chest. 126, 6, p. 1926-1932 7 p.

Research output: Contribution to journalArticle

NFATC Transcription Factors
Calcineurin
Atrial Fibrillation
Signal Transduction
Swine
134 Citations (Scopus)

Activation of the cellular oncogene c-erbB by ltr insertion: Molecular basis for induction of erythroblastosis by avian leukosis virus

Fung, Y. K. T., Lewis, W. G., Crittenden, L. B. & Kung, H. J., Jan 1 1983, In : Cell. 33, 2, p. 357-368 12 p.

Research output: Contribution to journalArticle

Avian Leukosis Virus
Viruses
Oncogenes
Chemical activation
Retroviridae
22 Citations (Scopus)

Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells

Lam, F. F. Y., Seto, S. W., Kwan, Y. W., Yeung, J. H. K. & Chan, P., Sep 28 2006, In : European Journal of Pharmacology. 546, 1-3, p. 28-35 8 p.

Research output: Contribution to journalArticle

Salvia miltiorrhiza
Smooth Muscle Myocytes
Coronary Vessels
Swine
Guanylate Cyclase
Oxidative stress
MAP Kinase Signaling System
Nicotinic Receptors
Spasm
p38 Mitogen-Activated Protein Kinases
78 Citations (Scopus)

Activation of the Notch1/STAT3/Twist signaling axis promotes gastric cancer progression

Hsu, K. W., Hsieh, R. H., Huang, K. H., Li, A. F. Y., Chi, C. W., Wang, T. Y., Tseng, M. J., Wu, K. J. & Tsai, T-S., Aug 2012, In : Carcinogenesis. 33, 8, p. 1459-1467 9 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Stomach Neoplasms
Notch1 Receptor
Neoplasms
Stomach
19 Citations (Scopus)

Activation of the renin-angiotensin system in hyperoxia-induced lung fibrosis in neonatal rats

Jiang, J. S., Lang, Y. D., Chou, H-C., Shih, C-M., Wu, M. Y., Chen, C-M. & Wang, L-F., Dec 2011, In : Neonatology. 101, 1, p. 47-54 8 p.

Research output: Contribution to journalArticle

Hyperoxia
Renin-Angiotensin System
Fibrosis
Lung
Angiotensin Type 1 Receptor
25 Citations (Scopus)

Activation of thromboxane receptor α induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cells

Wei, J., Yan, W., Li, X., Chang, W. C. & Tai, H. H., Sep 1 2007, In : Biochemical Pharmacology. 74, 5, p. 787-800 14 p.

Research output: Contribution to journalArticle

Thromboxane Receptors
Cyclooxygenase 2
Chemical activation
p38 Mitogen-Activated Protein Kinases
Transcription
137 Citations (Scopus)

Activation of topoisomerase II-mediated excision of chromosomal DNA loops during oxidative stress

Li, T. K., Chen, A. Y., Yu, C., Mao, Y., Wang, H. & Liu, L-F., Jun 15 1999, In : Genes and Development. 13, 12, p. 1553-1560 8 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
U937 Cells
Hydrogen Peroxide
Reactive Oxygen Species
Oxidative Stress
10 Citations (Scopus)

Activation of TWIST1 by COL11A1 promotes chemoresistance and inhibits apoptosis in ovarian cancer cells by modulating NF-κB-mediated IKKβ expression

Wu, Y. H., Huang, Y. F., Chang, T. H. & Chou, C. Y., Dec 1 2017, In : International Journal of Cancer. 141, 11, p. 2305-2317 13 p.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Apoptosis
Messenger RNA
Twist-Related Protein 1
Collagen Type XI
41 Citations (Scopus)

Activations of TRPA1 and P2X receptors are important in ROS-Mediated stimulation of capsaicin-Sensitive lung vagal afferents by cigarette smoke in rats

Lin, Y-S., Hsu, C-C., Bien, M-Y., Hsu, H-C., Weng, H-T. & Kou, Y-R., May 2010, In : Journal of Applied Physiology. 108, 5, p. 1293-1303 11 p.

Research output: Contribution to journalArticle

Ankyrins
Capsaicin
Smoke
Tobacco Products
Reactive Oxygen Species
78 Citations (Scopus)

Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy

Ho, H. N., Chao, K. H., Chen, C. K., Yang, Y. S. & Huang, S. C., Sep 1 1996, In : Human Immunology. 49, 2, p. 130-136 7 p.

Research output: Contribution to journalArticle

Menstrual Cycle
Endometrium
Decidua
Natural Killer Cells
T-Lymphocytes

Active and passive methods of detecting Parkinson's disease

Wen, C. J., Yen, A. M. F., Chiu, S. Y. H., Chen, S. L. S., Fann, J. C. Y., Hwang, Y. C., Chen, T. F., Wen, Y. R., Liou, H. H. & Chen, H. H., Jun 1 2015, In : Journal of the American Geriatrics Society. 63, 6, p. 1261-1263 3 p.

Research output: Contribution to journalArticle

Mass Screening
Parkinson Disease
24 Citations (Scopus)

Active and stable liquid water innovatively prepared using resonantly illuminated gold nanoparticles

Chen, H. C., Hwang, B. J., Mai, F. D., Liu, Y. C., Lin, C. M., Kuo, H-S., Chou, D. S., Lee, M. J., Yang, K. H., Yu, C. C., Chen, J. R., Lo, T. Y., Tsai, H. Y., Yang, C. P., Wang, C., Hsieh, H. T. & Rick, J., Mar 25 2014, In : ACS Nano. 8, 3, p. 2704-2713 10 p.

Research output: Contribution to journalArticle

Gold
gold
Nanoparticles
nanoparticles
Water
25 Citations (Scopus)

Active catalysts of electrochemically prepared gold nanoparticles for the decomposition of aldehyde in alcohol solutions

Liu, Y. C., Yu, C. C. & Yang, K. H., Jul 2006, In : Electrochemistry Communications. 8, 7, p. 1163-1167 5 p.

Research output: Contribution to journalArticle

Aldehydes
Gold
Alcohols
Nanoparticles
Decomposition
30 Citations (Scopus)

Active component of Danshen (Salvia miltiorrhiza Bunge), Tanshinone I, attenuates lung tumorigenesis via inhibitions of VEGF, Cyclin A, and Cyclin B expressions

Tung, Y. T., Chen, H. L., Lee, C. Y., Chou, Y. C., Lee, P. Y., Tsai, H. C., Lin, Y. L. & Chen, C. M., 2013, In : Evidence-based Complementary and Alternative Medicine. 2013, 319247.

Research output: Contribution to journalArticle

Salvia miltiorrhiza
Cyclin B
Cyclin A
Vascular Endothelial Growth Factor A
Carcinogenesis
33 Citations (Scopus)

Active constituents from Sophora japonica exhibiting cellular tyrosinase inhibition in human epidermal melanocytes

Lo, Y. H., Lin, R. D., Lin, Y. P., Liu, Y. L. & Lee, M. H., Jul 30 2009, In : Journal of Ethnopharmacology. 124, 3, p. 625-629 5 p.

Research output: Contribution to journalArticle

Sophora
Monophenol Monooxygenase
Melanocytes
Skin Care
Putrescine
59 Citations (Scopus)

Active films from water-soluble chitosan/cellulose composites incorporating releasable caffeic acid for inhibition of lipid oxidation in fish oil emulsions

Yu, S. H., Hsieh, H. Y., Pang, J. C., Tang, D. W., Shih, C. M., Tsai, M. L., Tsai, Y. C. & Mi, F. L., Jul 2013, In : Food Hydrocolloids. 32, 1, p. 9-19 11 p.

Research output: Contribution to journalArticle

Fish Oils
composite materials
Chitosan
Composite films
caffeic acid
6 Citations (Scopus)
MAP Kinase Signaling System
Non-Small Cell Lung Carcinoma
Lung Neoplasms
lissamine rhodamine B
Protein-Tyrosine Kinases
35 Citations (Scopus)

Active gellan gum/purple sweet potato composite films capable of monitoring pH variations

Wei, Y. C., Cheng, C. H., Ho, Y. C., Tsai, M. L. & Mi, F. L., Aug 1 2017, In : Food Hydrocolloids. 69, p. 491-502 12 p.

Research output: Contribution to journalArticle

Ipomoea batatas
gellan gum
Anthocyanins
Composite films
sweet potatoes
33 Citations (Scopus)

Active recombinant thioredoxin h protein with antioxidant activities from sweet potato (Ipomoea batatas [L.] Lam Tainong 57) storage roots

Huang, D. J., Chen, H. J., Hou, W. C., Lin, C. D. & Lin, Y. H., Jul 28 2004, In : Journal of Agricultural and Food Chemistry. 52, 15, p. 4720-4724 5 p.

Research output: Contribution to journalArticle

Thioredoxin h
Ipomoea batatas
sweet potatoes
thiocyanates
Antioxidants