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  (D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model

  Chiu, C. C., Weng, Y. H., Huang, Y. Z., Chen, R. S., Liu, Y. C., Yeh, T. H., Lu, C. S., Lin, Y. W., Chen, Y. J., Hsu, C. C., Chiu, C. H., Wang, Y. T., Chen, W. S., Liu, S. Y. & Wang, H. L., Nov 2020, In: Cell Death and Disease. 11, 11, 1018.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  10 Citations (Scopus)

• (G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

  Chen, C. Y., Weng, Y. H., Chien, K. Y., Lin, J. K., Yeh, T. H., Cheng, Y. P., Lu, C. S. & Wang, H. L., Oct 2012, In: Cell Death and Differentiation. 19, 10, p. 1623-1633 11 p.

  Research output: Contribution to journal › Article › peer-review
  113 Citations (Scopus)

• (G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

  Chou, J. S., Chen, C. Y., Chen, Y. L., Weng, Y. H., Yeh, T. H., Lu, C. S., Chang, Y. M. & Wang, H. L., 2014, In: Neurobiology of Disease. 68, p. 190-199 10 p.

  Research output: Contribution to journal › Article › peer-review
  33 Citations (Scopus)

• (Journal of Food and Drug Analysis 18, 6, (380))

  Cheng, Y. W. & Lou, H. Y., Jun 2011, In: Journal of Food and Drug Analysis. 19, 2, p. 243 1 p.

  Research output: Contribution to journal › Article › peer-review

• (N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo

  Lee, H. Y., Nepali, K., Huang, F. I., Chang, C. Y., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Feb 8 2018, In: Journal of Medicinal Chemistry. 61, 3, p. 905-917 13 p.

  Research output: Contribution to journal › Article › peer-review
  45 Citations (Scopus)

• (R1441C) LRRK2 induces the degeneration of SN dopaminergic neurons and alters the expression of genes regulating neuronal survival in a transgenic mouse model

  Weng, Y. H., Chen, C. Y., Lin, K. J., Chen, Y. L., Yeh, T. H., Hsiao, I. T., Chen, I. J., Lu, C. S. & Wang, H. L., Jan 1 2016, In: Experimental Neurology. 275, p. 104-115 12 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• (VO)²⁺ ions immobilized on functionalized surface of mesoporous silica and their activity toward the hydroxylation of benzene

  Lee, C. H., Lin, T. S. & Mou, C. Y., Mar 20 2003, In: Journal of Physical Chemistry B. 107, 11, p. 2543-2551 9 p.

  Research output: Contribution to journal › Article › peer-review
  65 Citations (Scopus)

• [ ¹²³I]Epidepride neuroimaging of dopamine D ₂/D ₃ receptor in chronic MK-801-induced rat schizophrenia model

  Huang, Y. R., Shih, J. M., Chang, K. W., Huang, C., Wu, Y. L. & Chen, C. C., Aug 1 2012, In: Nuclear Medicine and Biology. 39, 6, p. 826-832 7 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• [¹²³I]Iodooctyl fenbufen amide as a SPECT tracer for imaging tumors that over-express COX enzymes

  Huang, H. L., Yeh, C. N., Lee, W. Y., Huang, Y. C., Chang, K. W., Lin, K. J., Tien, S. F., Su, W. C., Yang, C. H., Chen, J. T., Lin, W. J., Fan, S. S. & Yu, C. S., Apr 1 2013, In: Biomaterials. 34, 13, p. 3355-3365 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  11 Citations (Scopus)

• [¹⁸F]Fluorodeoxyglucose-positron emission tomography screening for lung cancer: A systematic review and meta-analysis

  Chien, C. R., Liang, J. A., Chen, J. H., Wang, H. N., Lin, C. C., Chen, C. Y., Wang, P. H., Kao, C. H. & Yeh, J. J., Dec 11 2013, In: Cancer Imaging. 13, 4, p. 458-465 8 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• [21] Chemokines and chemokine receptors in model neurological pathologies: Molecular and immunocytochemical approaches

  Ransohoff, R. M., Tani, M., Glabinski, A. R., Chernosky, A., Krivacic, K., Peterson, J. W., Chien, H. F. & Trapp, B. D., Jan 1 1997, In: Methods in Enzymology. 287, p. 319-348 30 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• [35] Aromatic-amino acid-glyoxylate aminotransferase from rat liver

  Takada, Y. & Noguchi, T., 1987, In: Methods in Enzymology. 142, C, p. 273-279 7 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• [5,10,15,20-Tetra-(N-methyl-3-pyridyl)porphyrin destabilizes the anti-parallel telomeric quadruplex d(TTAGGG)4].

  Dutikova, I. V., Borisova, O. F., Shchelkina, A. K., Lin, J., Huang, S., Shtil', A. A. & Kaliuzhnyǐ, D. N., Sep 2010, In: Molekuliarnaia biologiia. 44, 5, p. 929-937 9 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• [Expression and clinical significance of circadian gene Per2 in non-small cell lung cancer].

  Chi, C., He, Z. F., Liu, Y., Lin, X. M. & Sun, C. C., Jan 1 2013, In: Chinese Journal of Oncology. 35, 2, p. 129-131 3 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• [The study of susceptibility to carbon tetrachloride and benzene in offspring of expanded simple tandem repeats mutation mice exposed to formaldehyde].

  Wang, C., Liu, Y. R., Zhou, Y., Li, A. P. & Zhou, J. W., Jan 1 2011, In: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 29, 5, p. 324-329 6 p.

  Research output: Contribution to journal › Article › peer-review

• 1,2,3,4,6-penta-o-galloyl-beta-D-glucopyranoside inhibits proliferation of multiple myeloma cells accompanied with suppression of MYC expression

  Tseeleesuren, D., Kant, R., Yen, C. H., Hsiao, H. H. & Chen, Y. M. A., Feb 2 2018, In: Frontiers in Pharmacology. 9, FEB, 65.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• 1,2,3,4,6-Penta-O-galloyl-D-glucose Interrupts the Early Adipocyte Lifecycle and Attenuates Adiposity and Hepatic Steatosis in Mice with Diet-Induced Obesity

  Sathyanarayana, A. R., Lu, C. K., Liaw, C. C., Chang, C. C., Han, H. Y., Green, B. D., Huang, W. J., Huang, C., He, W. D., Lee, L. C. & Liu, H. K., Apr 1 2022, In: International journal of molecular sciences. 23, 7, 4052.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  1 Citation (Scopus)

• 1,25(OH)₂D₃ Alleviates Aβ(25-35)-Induced Tau Hyperphosphorylation, Excessive Reactive Oxygen Species, and Apoptosis Through Interplay with Glial Cell Line-Derived Neurotrophic Factor Signaling in SH-SY5Y Cells

  Lin, C. I., Chang, Y. C., Kao, N. J., Lee, W. J., Cross, T. W. & Lin, S. H., Jun 13 2020, In: International journal of molecular sciences. 21, 12, p. 1-17 17 p., 4215.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  9 Citations (Scopus)

• 1,25-Dihydroxyvitamin D₃ attenuates endotoxin-induced production of inflammatory mediators by inhibiting MAPK activation in primary cortical neuron-glia cultures

  Huang, Y. N., Ho, Y. J., Lai, C. C., Chiu, C. T. & Wang, J. Y., Aug 12 2015, In: Journal of Neuroinflammation. 12, 1, 147.

  Research output: Contribution to journal › Article › peer-review
  49 Citations (Scopus)

• 1,25-Dihydroxyvitamin D3 increases testosterone-induced 17beta-estradiol secretion and reverses testosterone-reduced connexin 43 in rat granulosa cells

  Lee, C. T., Wang, J. Y., Chou, K. Y. & Hsu, M. I., Sep 20 2014, In: Reproductive Biology and Endocrinology. 12, 1, 90.

  Research output: Contribution to journal › Article › peer-review
  26 Citations (Scopus)

• 1,25-Dihydroxyvitamin D₃ modulates the effects of sublethal BPA on mitochondrial function via activating PI3K-Akt pathway and 17β-estradiol secretion in rat granulosa cells

  Lee, C. T., Wang, J. Y., Chou, K. Y. & Hsu, M. I., Jan 1 2019, In: Journal of Steroid Biochemistry and Molecular Biology. 185, p. 200-211 12 p.

  Research output: Contribution to journal › Article › peer-review
  15 Citations (Scopus)

• 1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma

  Liu, Y. M., HuangFu, W. C., Huang, H. L., Wu, W. C., Chen, Y. L., Yen, Y., Huang, H. L., Nien, C. Y., Lai, M. J., Pan, S. L. & Liou, J. P., 2017, In: European Journal of Medicinal Chemistry. 140, p. 84-91 8 p.

  Research output: Contribution to journal › Article › peer-review
  10 Citations (Scopus)

• 1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4 H -indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine

  Chao, P. K., Ueng, S. H., Ou, L. C., Yeh, T. K., Chang, W. T., Chang, H. F., Chen, S. C., Tao, P. L., Law, P. Y., Loh, H. H., Cheng, M. F., Chuang, J. Y., Chen, C. T., Shih, C. & Yeh, S. H., May 1 2017, In: Anesthesiology. 126, 5, p. 952-966 15 p.

  Research output: Contribution to journal › Article › peer-review
  6 Citations (Scopus)

• 101菁英專案: 美國呼吸治療專業學術參訪紀要

  Bien, M., Kuo, HJ., Wu, CY., Chung, JC., Chuang, T. & Shih, C-H., Apr 2008, In: 中華民國呼吸照護簡訊. 19, 1, p. 13-17 5 p.

  Research output: Contribution to journal › Article › peer-review

• 10-Point CT-ASPECTS-based reperfusion therapy for unknown onset stroke

  Chang, C. C., Yeh, H. L., Hsiao, C. Y. & Lien, L. M., 2018, In: Journal of the Formosan Medical Association.

  Research output: Contribution to journal › Article › peer-review
  2 Citations (Scopus)

• 10 Years of experience with penile prosthesis implantation in Taiwanese patients

  Chiang, H-S., Wu, C. C. & Wen, T. C., Feb 2000, In: Journal of Urology. 163, 2, p. 476-480 5 p.

  Research output: Contribution to journal › Article › peer-review
  38 Citations (Scopus)

• 10-year trends in statin utilization in Taiwan: A retrospective study using Taiwan's National Health Insurance Research Database

  Hsieh, H. C., Hsu, J. C. & Lu, C. Y., May 1 2017, In: BMJ Open. 7, 5, e014150.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  25 Citations (Scopus)

• 10′(Z),13′(E)-Heptadecadienylhydroquinone Inhibits Swarming and Virulence Factors and Increases Polymyxin B Susceptibility in Proteus mirabilis

  Liu, M-C., Lin, S-B., Chien, H-F., Wang, W-B., Yuan, Y-H., Hsueh, P-R. & Liaw, S-J., 2012, In: PLoS One. 7, 9

  Research output: Contribution to journal › Article › peer-review
  14 Citations (Scopus)

• ¹¹¹in-cetuximab as a diagnostic agent by accessible epidermal growth factor (EGF) receptor targeting in human metastatic colorectal carcinoma

  Shih, Y. H., Peng, C. L., Lee, S. Y., Chiang, P. F., Yao, C. J., Lin, W. J., Luo, T. Y. & Shieh, M. J., 2015, In: Oncotarget. 6, 18, p. 16601-16610 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  15 Citations (Scopus)

• 11H-Isoquino[4,3-c]cinnolin-12-ones: Novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

  Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X., Yang, J. M., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., Feb 15 2004, In: Bioorganic and Medicinal Chemistry. 12, 4, p. 795-806 12 p.

  Research output: Contribution to journal › Article › peer-review
  60 Citations (Scopus)

• 11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents

  Feng, W., Satyanarayana, M., Tsai, Y. C., Liu, A. A., Liu, L. F. & LaVoie, E. J., Sep 15 2008, In: Bioorganic and Medicinal Chemistry. 16, 18, p. 8598-8606 9 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• 120 Hz low cross-talk stereoscopic display with intelligent LED backlight enabled by multi-dimensional controlling IC

  Liou, J. C. & Tseng, F. G., Dec 2009, In: Displays. 30, 4-5, p. 148-154 7 p.

  Research output: Contribution to journal › Article › peer-review
  12 Citations (Scopus)

• 124 laparoscopic-assisted vaginal hysterectomies

  Liu, W-M., 1996, In: Journal of the American Association of Gynecologic Laparoscopists. 3, p. s26-

  Research output: Contribution to journal › Article › peer-review

• 12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCα/ERK/NF-κB-dependent MMP-9 expression

  Lin, C. W., Shen, S. C., Chien, C. C., Yang, L. Y., Shia, L. T. & Chen, Y. C., 2010, In: Journal of Cellular Physiology. 225, 2, p. 472-481 10 p.

  Research output: Contribution to journal › Article › peer-review
  87 Citations (Scopus)

• 12-o-Tetradecanoylphorbol 13-acetate prevents baicalein-induced apoptosis via activation of protein kinase C and JNKs in human leukemia cells

  Chow, J-M., Shen, S-C., Wu, C. Y. & Chen, Y-C., Nov 2006, In: Apoptosis. 11, 11, p. 1999-2011 13 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• 12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents

  Feng, W., Satyanarayana, M., Tsai, Y. C., Liu, A. A., Liu, L. F. & LaVoie, E. J., Apr 1 2009, In: Bioorganic and Medicinal Chemistry. 17, 7, p. 2877-2885 9 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• ¹³¹I treatment for thyroid cancer and risk of developing primary hyperparathyroidism: A cohort study

  Lin, C. M., Doyle, P., Tsan, Y. T., Lee, C. H., Wang, J. D. & Chen, P. C., 2014, In: European Journal of Nuclear Medicine and Molecular Imaging. 41, 2, p. 253-259 7 p.

  Research output: Contribution to journal › Article › peer-review
  7 Citations (Scopus)

• 133Xenon ventilation scan as a functional assessment in bronchiectasis.

  Hung, T. C., Lin, H. C., Lin, K. J. & Kuo, H. P., Jan 1 1998, In: Changgeng yi xue za zhi / Changgeng ji nian yi yuan = Chang Gung medical journal / Chang Gung Memorial Hospital. 21, 4, p. 403-408 6 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• 135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) to Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice

  Wu, G. C., Lin, S. Y., Liang, H. J. & Hou, W. C., Jan 24 2018, In: Journal of Agricultural and Food Chemistry. 66, 3, p. 645-652 8 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)

• 13-acetoxysarcocrassolide exhibits cytotoxic activity against oral cancer cells through the interruption of the keap1/Nrf2/p62/SQSTM1 pathway: The need to move beyond classical concepts

  Liu, Y. C., Peng, B. R., Hsu, K. C., El-Shazly, M., Shih, S. P., Lin, T. E., Kuo, F. W., Chou, Y. C., Lin, H. Y. & Lu, M. C., Jul 23 2020, In: Marine Drugs. 18, 8, 382.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  8 Citations (Scopus)

• 13-cis-Retinoic acid induces cellular differentiation and durable remission in refractory cutaneous Ki-1 lymphoma

  Chow, J. M., Cheng, A. L., Su, I. J. & Wang, C. H., 1991, In: Cancer. 67, 10, p. 2490-2494 5 p.

  Research output: Contribution to journal › Article › peer-review
  22 Citations (Scopus)

• ¹³C-NMR of the Deoxyribose Sugars in Four DNA Oligonucleotide Duplexes: Assignment and Structural Features

  LaPlante, S. R., Zanatta, N., Hakkinen, A., Wang, A. H. J. & Borer, P. N., Mar 1 1994, In: Biochemistry. 33, 9, p. 2430-2440 11 p.

  Research output: Contribution to journal › Article › peer-review
  18 Citations (Scopus)

• 15,16-Dihydrotanshinone I, a compound of salvia miltiorrhiza bunge, induces apoptosis through inducing endoplasmic reticular stress in human prostate carcinoma cells

  Liang, Y. C., Chuang, M. T., Ho, F. M., Wu, C. C., Zhuang, S. Y., Lin, S. Y. & Suk, F. M., 2011, In: Evidence-based Complementary and Alternative Medicine. 2011, 865435.

  Research output: Contribution to journal › Article › peer-review
  25 Citations (Scopus)

• 15,16-dihydrotanshinone I from the functional food Salvia miltiorrhiza exhibits anticancer activity in human HL-60 leukemia cells: In Vitro and in Vivo studies

  Liu, J. J., Wu, H. H., Chen, T. H., Leung, W. & Liang, Y. C., Aug 17 2015, In: International journal of molecular sciences. 16, 8, p. 19387-19400 14 p.

  Research output: Contribution to journal › Article › peer-review
  29 Citations (Scopus)

• 15,16-dihydrotanshinone i-induced apoptosis in human colorectal cancer cells: Involvement of ATF3

  Suk, F. M., Jou, W. J., Lin, R-J., Lin, S. Y., Tzeng, F. Y. & Liang, Y. C., Aug 2013, In: Anticancer Research. 33, 8, p. 3225-3232 8 p.

  Research output: Contribution to journal › Article › peer-review
  19 Citations (Scopus)

• 15-Deoxy-Δ^12,14-prostaglandin J₂ inhibits fibrogenic response in human hepatoma cells

  Suk, F. M., Chen, C. H., Lin, S. Y., Cheng, C. J., Yen, S. J., Hung, L. F., Liu, D. Z. & Liang, Y. C., May 22 2009, In: Toxicology Letters. 187, 1, p. 22-27 6 p.

  Research output: Contribution to journal › Article › peer-review
  17 Citations (Scopus)

• 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury

  Lin, T. N., Cheung, W. M., Wu, J. S., Chen, J. J., Lin, H., Chen, J. J., Liou, J. Y., Shyue, S. K. & Wu, K. K., Mar 2006, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 26, 3, p. 481-487 7 p.

  Research output: Contribution to journal › Article › peer-review
  119 Citations (Scopus)

• 15‐Hydroxyprostaglandin Dehydrogenase Activity in the Lower Genitourinary Tract A Preliminary Report

  CHANG, C. C., LIN, S. N., CHEN, F. S. & CHANG, W. C., Dec 1991, In: British Journal of Urology. 68, 6, p. 579-581 3 p.

  Research output: Contribution to journal › Article › peer-review
  5 Citations (Scopus)

• 15-Year outcome of treated bipolar disorder

  Tsai, S. Y. M., Chen, C. C., Kuo, C. J., Lee, J. C., Lee, H. C. & Strakowski, S. M., 2001, In: Journal of Affective Disorders. 63, 1-3, p. 215-220 6 p.

  Research output: Contribution to journal › Article › peer-review
  56 Citations (Scopus)

• 17 beta-estradiol inhibits tumor necrosis factor-alpha-induced nuclear factor-kappa B activation by increasing nuclear factor-kappa B p105 level in MCF-7 breast cancer cells

  Hsu, S. M., Chen, Y. C. & Jiang, M. C., Dec 9 2000, In: Biochemical and Biophysical Research Communications. 279, 1, p. 47-52 6 p.

  Research output: Contribution to journal › Article › peer-review
  50 Citations (Scopus)