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4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo

Mehndiratta, S., Wang, R. S., Huang, H. L., Su, C. J., Hsu, C. M., Wu, Y. W., Pan, S. L. & Liou, J. P., Jul 7 2017, In : European Journal of Medicinal Chemistry. 134, p. 13-23 11 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

4-O-Caffeoylquinic acid as an antioxidant marker for mulberry leaves rich in phenolic compounds

Ganzon, J. G., Chen, L. G. & Wang, C. C., 2018, In : Journal of Food and Drug Analysis.

Research output: Contribution to journalArticle

5 Citations (Scopus)

4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest

Yen, C. Y., Chiu, C. C., Chang, F. R., Chen, J. Y., Hwang, C. C., Hseu, Y. C., Yang, H. L., Lee, A. Y. L., Tsai, M. T., Guo, Z. L., Cheng, Y. S., Liu, Y. C., Lan, Y. H., Chang, Y. C., Ko, Y. C., Chang, H. W. & Wu, Y. C., Feb 18 2010, In : BMC Cancer. 10, 46.

Research output: Contribution to journalArticle

67 Citations (Scopus)
6 Citations (Scopus)

5-(2-Aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: Variation of N-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance

Ruchelman, A. L., Houghton, P. J., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., Feb 10 2005, In : Journal of Medicinal Chemistry. 48, 3, p. 792-804 13 p.

Research output: Contribution to journalArticle

83 Citations (Scopus)

500-Gray γ-Irradiation May Increase Adhesion Strength of Lyophilized Cadaveric Split-Thickness Skin Graft to Wound Bed

Wei, L. G., Chen, C. F., Wang, C. H., Cheng, Y. C., Li, C. C., Chiu, W. K. & Wang, H-J., Feb 3 2017, (Accepted/In press) In : Annals of Plastic Surgery.

Research output: Contribution to journalArticle

58-kDa microspherule protein (MSP58) is novel brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway

Hsu, C. C., Lee, Y. C., Yeh, S. H., Chen, C. H., Wu, C. C., Wang, T. Y., Chen, Y. N., Hung, L. Y., Liu, Y. W., Chen, H. K., Hsiao, Y. T., Wang, W. S., Tsou, J. H., Tsou, Y. H., Wu, M. H., Chang, W. C. & Lin, D. Y., Jun 29 2012, In : Journal of Biological Chemistry. 287, 27, p. 22533-22548 16 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)

5A/6A polymorphism of the stromelysin-1 gene and angiographic restenosis after coronary artery stenting

Chiou, K. R., Chung, S. L. & Charng, M. J., Jan 1 2005, In : Journal of the Chinese Medical Association. 68, 11, p. 506-512 7 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase

Ji, H-T., Chien, L-T., Lin, Y-H., Chien, H-F. & Chen, C-T., 2010, In : Molecular Cancer. 9

Research output: Contribution to journalArticle

43 Citations (Scopus)

5-Amino-2-Aroylquinolines as highly potent tubulin polymerization inhibitors

Nien, C. Y., Chen, Y. C., Kuo, C. C., Hsieh, H. P., Chang, C. Y., Wu, J. S., Wu, S. Y., Liou, J. P. & Chang, J. Y., Mar 11 2010, In : Journal of Medicinal Chemistry. 53, 5, p. 2309-2313 5 p.

Research output: Contribution to journalArticle

63 Citations (Scopus)

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2

Lee, H. Y., Chang, J. Y., Nien, C. Y., Kuo, C. C., Shih, K. H., Wu, C. H., Chang, C. Y., Lai, W. Y. & Liou, J. P., Dec 22 2011, In : Journal of Medicinal Chemistry. 54, 24, p. 8517-8525 9 p.

Research output: Contribution to journalArticle

42 Citations (Scopus)

5-Aminolevulinic acid induced photodynamic inactivation on Staphylococcus aureus and Pseudomonas aeruginosa

Hsieh, C. M., Huang, Y. H., Chen, C. P., Hsieh, B. C. & Tsai, T., 2014, In : Journal of Food and Drug Analysis. 22, 3, p. 350-355 6 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes

Lee, H. Y., Fan, S. J., Huang, F. I., Chao, H. Y., Hsu, K. C., Lin, T. E., Yeh, T. K., Lai, M. J., Li, Y. H., Huang, H. L., Yang, C. R. & Liou, J. P., Jan 29 2018, (Accepted/In press) In : Journal of Medicinal Chemistry.

Research output: Contribution to journalArticle

14 Citations (Scopus)

5-Demethylnobiletin and 5-Acetoxy-6,7,8,3′,4′-pentamethoxyflavone Suppress Lipid Accumulation by Activating the LKB1-AMPK Pathway in 3T3-L1 Preadipocytes and High Fat Diet-Fed C57BL/6 Mice

Tung, Y. C., Li, S., Huang, Q., Hung, W. L., Ho, C. T., Wei, G. J. & Pan, M. H., Apr 27 2016, In : Journal of Agricultural and Food Chemistry. 64, 16, p. 3196-3205 10 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis

Ma, N., Lai, C. S., Chung, C. H., Yang, J. M., Hsu, K. C., Chen, C. Y., Chung, T. S., Li, S., Ho, C. T. & Pan, M. H., 2014, In : Journal of Functional Foods. 11, C, p. 528-537 10 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6] naphthyridin-6-ones and related compounds as TOP1-targeting agents: Influence of structure on the ternary cleavable complex formation

Kerrigan, J. E., Pilch, D. S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., Oct 20 2003, In : Bioorganic and Medicinal Chemistry Letters. 13, 20, p. 3395-3399 5 p.

Research output: Contribution to journalArticle

11 Citations (Scopus)

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: Novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity

Ruchelman, A. L., Singh, S. K., Ray, A., Wu, X. H., Yang, J. M., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., May 1 2003, In : Bioorganic and Medicinal Chemistry. 11, 9, p. 2061-2073 13 p.

Research output: Contribution to journalArticle

88 Citations (Scopus)

5-HT modulates multiple conductances in immature rat rostral ventrolateral medulla neurones in vitro

Hwang, L. L. & Dun, N. J., May 15 1999, In : Journal of Physiology. 517, 1, p. 217-228 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

5-Hydroxytryptamine responses in immature rat rostral ventrolateral medulla neurons in vitro

Hwang, L-L. & Dun, N. J., Sep 1998, In : Journal of Neurophysiology. 80, 3, p. 1033-1041 9 p.

Research output: Contribution to journalArticle

12 Citations (Scopus)

5′CpG island hypermethylation and aberrant transcript splicing both contribute to the inactivation of the FHIT gene in resected non-small cell lung cancer

Tzao, C., Tsai, H. Y., Chen, J. T., Chen, C. Y. & Wang, Y. C., Sep 2004, In : European Journal of Cancer. 40, 14, p. 2175-2183 9 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

5-氟尿嘧啶單獨或併用遊離輻射治療人類結腸直腸癌細胞之效果

Translated title of the contribution: Combined Treatment Effect of 5-Fluorouracil with Ionizing Radiation on Human Colorectal Carcinoma Cells黃正仲, 陳柏元, 鄧文炳, 黃家瑜, 林冠如, 吳國海, 傅秉三 & 林芳仁, 1999, In : 放射治療與腫瘤學. 6, 2, p. 73-82 10 p.

Research output: Contribution to journalArticle

6,7-dihydroxy-2-(4′-hydroxyphenyl)naphthalene induces HCT116 cell apoptosis through activation of endoplasmic reticulum stress and the extrinsic apoptotic pathway

Chiu, C. F., Lai, G. Y., Chen, C. H., Chiu, C. C., Hung, S. W. & Chang, C. F., Jan 1 2019, In : Drug Design, Development and Therapy. 13, p. 1609-1621 13 p.

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

60Co contamination in recycled steel resulting in elevated civilian radiation doses: Causes and challenges

Chang, W. P., Chan, C. C. & Wang, J. D., Sep 1997, In : Health Physics. 73, 3, p. 465-472 8 p.

Research output: Contribution to journalArticle

45 Citations (Scopus)
3 Citations (Scopus)

6-Acyl-4-aryl/alkyl-5,7-dihydroxycoumarins as anti-inflammatory agents

Lin, C. M., Huang, S. T., Lee, F. W., Kuo, H. S. & Lin, M. H., Jul 1 2006, In : Bioorganic and Medicinal Chemistry. 14, 13, p. 4402-4409 8 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

6-Dehydrogingerdione sensitizes human hepatoblastoma hep G2 cells to trail-induced apoptosis via reactive oxygen species-mediated increase of dr5

Chen, C. Y., Tai, C. J., Cheng, J. T., Zheng, J. J., Chen, Y. Z., Liu, T. Z., Yiin, S. J. & Chern, C. L., May 12 2010, In : Journal of Agricultural and Food Chemistry. 58, 9, p. 5604-5611 8 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity

Zhu, S., Ruchelman, A. L., Zhou, N., Liu, A., Liu, L-F. & LaVoie, E. J., May 1 2006, In : Bioorganic and Medicinal Chemistry. 14, 9, p. 3131-3143 13 p.

Research output: Contribution to journalArticle

22 Citations (Scopus)

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., Kuo, C. C. & Liou, J. P., Nov 16 2006, In : Journal of Medicinal Chemistry. 49, 23, p. 6656-6659 4 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration

Tsai, C. C., Liu, H. F., Hsu, K. C., Yang, J. M., Chen, C., Liu, K. K., Hsu, T. S. & Chao, J. I., Apr 1 2011, In : Biochemical Pharmacology. 81, 7, p. 856-865 10 p.

Research output: Contribution to journalArticle

10 Citations (Scopus)
14 Citations (Scopus)

8,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-targeting activity and cytotoxicity

Li, D., Zhao, B., Sim, S. P., Li, T. K., Liu, A., Liu, L-F. & LaVoie, E. J., Aug 15 2003, In : Bioorganic and Medicinal Chemistry. 11, 17, p. 3795-3805 11 p.

Research output: Contribution to journalArticle

32 Citations (Scopus)

836 10-years experience in cystitis glandularis

Chang, C. H. C., Chen, K-K., Lin, T. L., Pan, C-C., Chang, Y-H., Huang, J., Kuo, J-Y., Chung, H-J. & Lin, T. L., Apr 1 2015, In : European Urology, Supplements. 14, 2, p. e836

Research output: Contribution to journalArticle

99mTc pyrene derivative complex causes double-strand breaks in dsDNA mainly through cluster-mediated indirect effect in aqueous solution

Chung, W. J., Cui, Y., Huang, F. Y. J., Tu, T. H., Yang, T. S., Lo, J. M., Chiang, C. S. & Hsu, I. C., Sep 22 2014, In : PLoS One. 9, 9, e108162.

Research output: Contribution to journalArticle

2 Citations (Scopus)

99mtc-trodat-1 spect in healthy and 6-ohda lesioned parkinsonian monkeys: comparison with f-fdopa pet

Huang, W. S., MA, K. H., Chou, Y. H., Chen, C. Y., Liu, R. S. & Liu, J. C., Jan 1 2003, In : Nuclear Medicine Communications. 24, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

99mTc-TRODAT-1 SPECT in healthy and 6-OHDA lesioned parkinsonian monkeys: Comparison with 18F-FDOPA PET

Huang, W. S., Ma, K. H., Chou, Y. H., Chen, C. Y., Liu, R. S. & Liu, J. C., Jan 2003, In : Nuclear Medicine Communications. 24, 1, p. 77-83 7 p.

Research output: Contribution to journalArticle

9-cis retinoic acid induces neurorepair in stroke brain

Yu, S. J., Airavaara, M., Wu, K. J., Harvey, B. K., Liu, H. S., Yang, Y., Zacharek, A., Chen, J. & Wang, Y., Dec 1 2017, In : Scientific Reports. 7, 1, 4512.

Research output: Contribution to journalArticle

6 Citations (Scopus)
10 Citations (Scopus)

9-Cis-retinoic acid reduces ischemic brain injury in rodents via bone morphogenetic protein

Shen, H., Luo, Y., Kuo, C. C., Deng, X., Fang, C. F., Harvey, B. K., Hoffer, B. J. & Wang, Y., Feb 1 2009, In : Journal of Neuroscience Research. 87, 2, p. 545-555 11 p.

Research output: Contribution to journalArticle

27 Citations (Scopus)

A 10-year follow-up of triple-negative breast cancer patients in Taiwan

Lin, C., Chien, S. Y., Kuo, S. J., Chen, L. S., Chen, S. T., Lai, H. W., Chang, T. W. & Chen, D. R., Mar 2012, In : Japanese Journal of Clinical Oncology. 42, 3, p. 161-167 7 p., hyr196.

Research output: Contribution to journalArticle

7 Citations (Scopus)

A 10-year follow-up study on suicidal mortality after 1999 Taiwan earthquake

Chen, S. L. S., Lee, C. S., Yen, A. M. F., Chen, H. H., Chan, C. C., Chiu, S. Y. H., Fann, J. C. Y. & Chang, J. C., Aug 1 2016, In : Journal of Psychiatric Research. 79, p. 42-49 8 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A 12-year-old boy with an infected ectopic ureter presenting with acute appendicitis-like symptoms and acute scrotum

Chu, W. Y., Tsao, T. F., Chen, S. L., Chang, H. M., Chen, S. M., Chen, C. Y., Lue, K. H. & Sheu, J. N., Jun 2012, In : Scandinavian Journal of Urology and Nephrology. 46, 3, p. 208-211 4 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

A 17-Year-Old Student with Dysphagia

Cheng, Y. C., Lou, H. Y., Chang, C-C. & Lin, H-J., 2013, In : Gastroenterological Journal of Taiwan. 30, 1, p. 41-42 2 p.

Research output: Contribution to journalArticle

A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma

Dong, G., Chanudet, E., Zeng, N., Appert, A., Chen, Y. W., Au, W. Y., Hamoudi, R. A., Watkins, A. J., Ye, H., Liu, H., Gao, Z., Chuang, S. S., Srivastava, G. & Du, M. Q., Mar 15 2011, In : Clinical Cancer Research. 17, 6, p. 1440-1451 12 p.

Research output: Contribution to journalArticle

48 Citations (Scopus)

A 20 year clinical and laboratory study of familial b-chronic lymphocytic leukemia in a single kindred

Caporaso, N. E., Whitehouse, J., Bertin, P., Amos, C., Papadopoulos, N., Muller, J., Whang-peng, J., Tucker, M. A., Fleisher, T. A. & Marti, G. E., Jan 1 1991, In : Leukemia and Lymphoma. 3, 5-6, p. 331-342 12 p.

Research output: Contribution to journalArticle

8 Citations (Scopus)

A 22-year-old woman had a lung mass

Lee, C. H., Cheng, C. J. & Chan, W. P., 2013, In : Annals of the Academy of Medicine Singapore. 42, 2, p. 95-96 2 p.

Research output: Contribution to journalArticle

A 260- μ W down-conversion demodulator for MICS-band receiver

Chang, C. H., Gong, C. S. A., Liou, J. C., Tsou, Y. L., Shiu, F. L., Chiou, H. K. & Tu, P. H., Feb 1 2017, In : Journal of Circuits, Systems and Computers. 26, 2, 1750027.

Research output: Contribution to journalArticle

1 Citation (Scopus)

A 2-year follow-up of swallowing function after radiation therapy in patients with nasopharyngeal carcinoma

Chang, Y. C., Chen, S. Y., Ting, L. L., Peng, S. S. F., Wang, T. C. & Wang, T. G., Nov 1 2011, In : Archives of Physical Medicine and Rehabilitation. 92, 11, p. 1814-1819 6 p.

Research output: Contribution to journalArticle

6 Citations (Scopus)

A 3-day anti-Helicobacter pylori therapy is a good alternative for bleeding peptic ulcer patients with Helicobacter pylori infection

Hsieh, Y. H., Lin, H. J., Tseng, G. Y., Perng, C. L., Chang, F. Y. & Lee, S. D., 2001, In : Hepato-Gastroenterology. 48, 40, p. 1078-1081 4 p.

Research output: Contribution to journalArticle

9 Citations (Scopus)

A 3-year follow-up study on the risk of stroke among patients with conjunctival haemorrhage

Wang, T. J., Keller, J. J., Sheu, J. J. & Lin, H. C., May 2013, In : Acta Ophthalmologica. 91, 3, p. 226-230 5 p.

Research output: Contribution to journalArticle

3 Citations (Scopus)

A 45-kDa ErbB3 secreted by prostate cancer cells promotes bone formation

Lin, S. H., Cheng, C. J., Lee, Y. C., Ye, X., Tsai, W. W., Kim, J., Pasqualini, R., Arap, W., Navone, N. M., Tu, S. M., Hu, M., Yu-Lee, L. Y. & Logothetis, C. J., Sep 4 2008, In : Oncogene. 27, 39, p. 5195-5203 9 p.

Research output: Contribution to journalArticle

20 Citations (Scopus)