9-cis retinoic acid induces neurorepair in stroke brain

Seong Jin Yu, Mikko Airavaara, Kuo Jen Wu, Brandon K. Harvey, H. S. Liu, Yihong Yang, Alex Zacharek, Jieli Chen, Yun Wang

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Abstract

The purpose of this study was to examine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke. Adult male rats received a 90-min right distal middle cerebral artery occlusion (dMCAo). Animals were separated into two groups with similar infarction sizes, based on magnetic resonance imaging on day 2 after dMCAo. 9cRA or vehicle was given via an intranasal route daily starting from day 3. Stroke rats receiving 9cRA post-treatment showed an increase in brain 9cRA levels and greater recovery in motor function. 9cRA enhanced the proliferation of bromodeoxyuridine (+) cells in the subventricular zone (SVZ) and lesioned cortex in the stroke brain. Using subventricular neurosphere and matrigel cultures, we demonstrated that proliferation and migration of SVZ neuroprogenitor cells were enhanced by 9cRA. Our data support a delayed and non-invasive drug therapy for stroke. Intranasal 9cRA can facilitate the functional recovery and endogenous repair in the ischemic brain.

Original languageEnglish
Article number4512
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017
Externally publishedYes

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Yu, S. J., Airavaara, M., Wu, K. J., Harvey, B. K., Liu, H. S., Yang, Y., Zacharek, A., Chen, J., & Wang, Y. (2017). 9-cis retinoic acid induces neurorepair in stroke brain. Scientific Reports, 7(1), [4512]. https://doi.org/10.1038/s41598-017-04048-2