7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents

Jang Yang Chang, Hsing Pang Hsieh, Chi Yen Chang, Kuo Shun Hsu, Yi Fang Chiang, Chi Ming Chen, Ching Chuan Kuo, Jing Ping Liou

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

A novel series of 7-aroyl-aminoindoline-1-benzenesulfonamides showed excellent activity as inhibitors of tubulin polymerization through binding with the colchicine binding site of microtubules. Compound 15 and 16 display IC 50 values of 1.1 and 1.2 μM, respectively. Compound 15 inhibited the human cancer cell growth of KB, MKN45, H460, HT29, and TSGH, as well as one human-resistant cancer line of KB-vin 10, with an IC50 of 9.6, 8.8, 9.4, 8.6, 10.8, and 8.9 nM, respectively.

Original languageEnglish
Pages (from-to)6656-6659
Number of pages4
JournalJournal of Medicinal Chemistry
Volume49
Issue number23
DOIs
Publication statusPublished - Nov 16 2006

Fingerprint

Tubulin Modulators
Sulfonamides
Colchicine
Cell growth
Display devices
Binding Sites
KB Cells
Microtubules
Inhibitory Concentration 50
Neoplasms
Growth
benzenesulfonamide

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Chang, J. Y., Hsieh, H. P., Chang, C. Y., Hsu, K. S., Chiang, Y. F., Chen, C. M., ... Liou, J. P. (2006). 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents. Journal of Medicinal Chemistry, 49(23), 6656-6659. https://doi.org/10.1021/jm061076u

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents. / Chang, Jang Yang; Hsieh, Hsing Pang; Chang, Chi Yen; Hsu, Kuo Shun; Chiang, Yi Fang; Chen, Chi Ming; Kuo, Ching Chuan; Liou, Jing Ping.

In: Journal of Medicinal Chemistry, Vol. 49, No. 23, 16.11.2006, p. 6656-6659.

Research output: Contribution to journalArticle

Chang, JY, Hsieh, HP, Chang, CY, Hsu, KS, Chiang, YF, Chen, CM, Kuo, CC & Liou, JP 2006, '7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents', Journal of Medicinal Chemistry, vol. 49, no. 23, pp. 6656-6659. https://doi.org/10.1021/jm061076u
Chang JY, Hsieh HP, Chang CY, Hsu KS, Chiang YF, Chen CM et al. 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents. Journal of Medicinal Chemistry. 2006 Nov 16;49(23):6656-6659. https://doi.org/10.1021/jm061076u
Chang, Jang Yang ; Hsieh, Hsing Pang ; Chang, Chi Yen ; Hsu, Kuo Shun ; Chiang, Yi Fang ; Chen, Chi Ming ; Kuo, Ching Chuan ; Liou, Jing Ping. / 7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents. In: Journal of Medicinal Chemistry. 2006 ; Vol. 49, No. 23. pp. 6656-6659.
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