5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis

Nianhan Ma, Ching Shu Lai, Chih Han Chung, Jinn Moon Yang, Kai Cheng Hsu, Chin Yu Chen, Tao Sheng Chung, Shiming Li, Chi Tang Ho, Min Hsiung Pan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

5-Demethyltangeretin (5-DTAN), an autohydrolysis product of tangeretin (TAN) found in citrus peel, exhibited more potent anti-proliferative activity in human cancer cells than TAN itself. In this study, we investigated the anti-tumor promoting effect and underlying molecular mechanism of 5-DTAN on 7,12-dimethyl-benz(a)anthracene (DMBA)-induced and 12-. O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis. Application of 5-DTAN prior to each TPA-treatment was more effective than that of TAN on reducing the number, incidence and size of papillomas in DMBA-initiated mouse skin. Moreover, 5-DTAN suppressed cyclooxygenase-2 (COX-2) protein expression more strongly than TAN through interfering with phosphatidylinositiol 3-kinase (PI3K)/Akt signaling and further activation of transcription factor NF-κB. Taken together, these results revealed for the first time the in vivo chemopreventive efficacy of 5-DTAN on inhibition of skin carcinogenesis through promoting apoptosis and molecular interactions with residues of PI3K, COX-2, and AKT that may potentially serve as a novel functional agent capable of preventing inflammation-associated tumorigenesis.

Original languageEnglish
Pages (from-to)528-537
Number of pages10
JournalJournal of Functional Foods
Volume11
Issue numberC
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Tetradecanoylphorbol Acetate
skin (animal)
carcinogenesis
Carcinogenesis
acetates
prostaglandin synthase
Skin
phosphotransferases (kinases)
1-Phosphatidylinositol 4-Kinase
citrus peels
Cyclooxygenase 2
papilloma
apoptosis
transcription factors
protein synthesis
inflammation
9,10-Dimethyl-1,2-benzanthracene
Citrus
Papilloma
incidence

Keywords

  • 5-Demethyltangeretin
  • DMBA
  • Inflammation
  • Tangeretin
  • TPA

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis. / Ma, Nianhan; Lai, Ching Shu; Chung, Chih Han; Yang, Jinn Moon; Hsu, Kai Cheng; Chen, Chin Yu; Chung, Tao Sheng; Li, Shiming; Ho, Chi Tang; Pan, Min Hsiung.

In: Journal of Functional Foods, Vol. 11, No. C, 2014, p. 528-537.

Research output: Contribution to journalArticle

Ma, Nianhan ; Lai, Ching Shu ; Chung, Chih Han ; Yang, Jinn Moon ; Hsu, Kai Cheng ; Chen, Chin Yu ; Chung, Tao Sheng ; Li, Shiming ; Ho, Chi Tang ; Pan, Min Hsiung. / 5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis. In: Journal of Functional Foods. 2014 ; Vol. 11, No. C. pp. 528-537.
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abstract = "5-Demethyltangeretin (5-DTAN), an autohydrolysis product of tangeretin (TAN) found in citrus peel, exhibited more potent anti-proliferative activity in human cancer cells than TAN itself. In this study, we investigated the anti-tumor promoting effect and underlying molecular mechanism of 5-DTAN on 7,12-dimethyl-benz(a)anthracene (DMBA)-induced and 12-. O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis. Application of 5-DTAN prior to each TPA-treatment was more effective than that of TAN on reducing the number, incidence and size of papillomas in DMBA-initiated mouse skin. Moreover, 5-DTAN suppressed cyclooxygenase-2 (COX-2) protein expression more strongly than TAN through interfering with phosphatidylinositiol 3-kinase (PI3K)/Akt signaling and further activation of transcription factor NF-κB. Taken together, these results revealed for the first time the in vivo chemopreventive efficacy of 5-DTAN on inhibition of skin carcinogenesis through promoting apoptosis and molecular interactions with residues of PI3K, COX-2, and AKT that may potentially serve as a novel functional agent capable of preventing inflammation-associated tumorigenesis.",
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AU - Lai, Ching Shu

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AU - Hsu, Kai Cheng

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AU - Chung, Tao Sheng

AU - Li, Shiming

AU - Ho, Chi Tang

AU - Pan, Min Hsiung

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AB - 5-Demethyltangeretin (5-DTAN), an autohydrolysis product of tangeretin (TAN) found in citrus peel, exhibited more potent anti-proliferative activity in human cancer cells than TAN itself. In this study, we investigated the anti-tumor promoting effect and underlying molecular mechanism of 5-DTAN on 7,12-dimethyl-benz(a)anthracene (DMBA)-induced and 12-. O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis. Application of 5-DTAN prior to each TPA-treatment was more effective than that of TAN on reducing the number, incidence and size of papillomas in DMBA-initiated mouse skin. Moreover, 5-DTAN suppressed cyclooxygenase-2 (COX-2) protein expression more strongly than TAN through interfering with phosphatidylinositiol 3-kinase (PI3K)/Akt signaling and further activation of transcription factor NF-κB. Taken together, these results revealed for the first time the in vivo chemopreventive efficacy of 5-DTAN on inhibition of skin carcinogenesis through promoting apoptosis and molecular interactions with residues of PI3K, COX-2, and AKT that may potentially serve as a novel functional agent capable of preventing inflammation-associated tumorigenesis.

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