30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure

Wan Hua Hsieh, I. Feng Lin, Jung Chun Ho, Peter Wushou Chang

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: The current study followed-up site-specific cancer risks in an unique cohort with 30 years' follow-up after long-term low-dose-rate radiation exposure in Taiwan.

METHODS: Six thousand two hundred and forty two Taiwanese people received extra exposure in residential and school buildings constructed with Co-60-contaminated steel from 1982 until informed and relocated in early 1990s. The additional doses received have been estimated. During 1983-2012, 300 cancer cases were identified through the national cancer registry in Taiwan, 247 cases with minimum latent periods from initial exposure. The hazard ratios (HR) of site-specific cancers were estimated with additional cumulative exposure estimated individually.

RESULTS: Dose-dependent risks were statistically significantly increased for leukaemia excluding chronic lymphocytic leukaemia (HR100mSv 1.18; 90% CI 1.04-1.28), breast cancers (HR100mSv 1.11; 90% CI 1.05-1.20), and all cancers (HR100mSv 1.05; 90% CI 1.0-1.08, P=0.04). Women with an initial age of exposure lower than 20 were shown with dose response increase in breast cancers risks (HR100mSv 1.38; 90% CI 1.14-1.60; P=0.0008).

CONCLUSIONS: Radiation exposure before age 20 was associated with a significantly increased risk of breast cancer at much lower radiation exposure than observed previously.

Original languageEnglish
Pages (from-to)1883-1887
Number of pages5
JournalBritish Journal of Cancer
Volume117
Issue number12
DOIs
Publication statusPublished - Dec 5 2017

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Leukemia
Breast Neoplasms
Neoplasms
Taiwan
Steel
B-Cell Chronic Lymphocytic Leukemia
Registries
Radiation Exposure

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure. / Hsieh, Wan Hua; Lin, I. Feng; Ho, Jung Chun; Chang, Peter Wushou.

In: British Journal of Cancer, Vol. 117, No. 12, 05.12.2017, p. 1883-1887.

Research output: Contribution to journalArticle

Hsieh, Wan Hua ; Lin, I. Feng ; Ho, Jung Chun ; Chang, Peter Wushou. / 30 years follow-up and increased risks of breast cancer and leukaemia after long-term low-dose-rate radiation exposure. In: British Journal of Cancer. 2017 ; Vol. 117, No. 12. pp. 1883-1887.
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