15d-prostaglandin J2 protects brain from ischemia-reperfusion injury

Teng Nan Lin, Wai Mui Cheung, Jui Sheng Wu, Jean Ju Chen, Heng Lin, Jin Jer Chen, Jun Yang Liou, Song Kun Shyue, Kenneth K. Wu

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Objective - Brain expresses abundant lipocalin-type prostaglandin (PG) D2 (PGD2) synthase but the role of PGD2 and its metabolite, 15-deoxy-Δ12,14 PGJ2 (15d-PGJ 2) in brain protection is unclear. The aim of this study is to assess the effect of 15d-PGJ2 on neuroprotection. Methods and Results - Adenoviral transfer of cyclooxygenase-1 (Adv-COX-1) was used to amplify the production of 15d-PGJ2 in ischemic cortex in a rat focal infarction model. Cortical 15d-PGJ2 in Adv-COX-1-treated rats was increased by 3-fold over control, which was correlated with reduced infarct volume and activated caspase 3, and increased peroxisome proliferator activated receptor-γ (PPARγ) and heme oxygenase-1 (HO-1). Intraventricular infusion of 15d-PGJ2 resulted in reduction of infarct volume, which was abrogated by a PPARγ inhibitor. Rosiglitazone infusion had a similar effect. 15d-PGJ2 and rosiglitazone at low concentrations suppressed H2O2-induced rat or human neuronal apoptosis and necrosis and induced PPARγ and HO-1 expression. The anti-apoptotic effect was abrogated by PPARγ inhibition. Conclusion - 15d-PGJ2 suppressed ischemic brain infarction and neuronal apoptosis and necrosis in a PPARγ dependent manner. 15d-PGJ2 may play a role in controlling acute brain damage induced by ischemia-reperfusion.

Original languageEnglish
Pages (from-to)481-487
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume26
Issue number3
DOIs
Publication statusPublished - Mar 2006
Externally publishedYes

Fingerprint

Peroxisome Proliferator-Activated Receptors
Reperfusion Injury
Brain Ischemia
rosiglitazone
Cyclooxygenase 1
Heme Oxygenase-1
prostaglandin R2 D-isomerase
Brain
Necrosis
Apoptosis
Intraventricular Infusions
Brain Infarction
Lipocalins
Caspase 3
Infarction
Reperfusion
Ischemia
9-deoxy-delta-9-prostaglandin D2

Keywords

  • 15d-PGJ
  • Apoptosis
  • COX-1
  • PPARγ
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. / Lin, Teng Nan; Cheung, Wai Mui; Wu, Jui Sheng; Chen, Jean Ju; Lin, Heng; Chen, Jin Jer; Liou, Jun Yang; Shyue, Song Kun; Wu, Kenneth K.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 26, No. 3, 03.2006, p. 481-487.

Research output: Contribution to journalArticle

Lin, TN, Cheung, WM, Wu, JS, Chen, JJ, Lin, H, Chen, JJ, Liou, JY, Shyue, SK & Wu, KK 2006, '15d-prostaglandin J2 protects brain from ischemia-reperfusion injury', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 3, pp. 481-487. https://doi.org/10.1161/01.ATV.0000201933.53964.5b
Lin, Teng Nan ; Cheung, Wai Mui ; Wu, Jui Sheng ; Chen, Jean Ju ; Lin, Heng ; Chen, Jin Jer ; Liou, Jun Yang ; Shyue, Song Kun ; Wu, Kenneth K. / 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2006 ; Vol. 26, No. 3. pp. 481-487.
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AU - Lin, Heng

AU - Chen, Jin Jer

AU - Liou, Jun Yang

AU - Shyue, Song Kun

AU - Wu, Kenneth K.

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