Abstract
In the pathway of prostaglandin inactivation, 15-hydroxyprostaglandin dehydrogenase (15-OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15-hydroxyl group into a 15-keto moiety in most derivatives of prostaglandins. In this study, we analysed 15-OHPGDH activity in the lower genitourinary tract. The specimens were obtained with permission from patients who underwent surgery. These specimens were then sent for quantitative determination using a tritium release assay specific for 15-OHPGDH. The highest enzyme activity was found in the ureter with a mean ± SE (pmol/min/mg) of 94.99 ± 51.00; the lowest activity was in the vas deferens, with a value of 0.18 ± 0.21. This preliminary study indicated that the activity of 15-OHPGDH in the lower genitourinary tract was significant and that prostaglandin levels in the genitourinary tract may be regulated by this enzyme.
| Original language | English |
|---|---|
| Pages (from-to) | 579-581 |
| Number of pages | 3 |
| Journal | British Journal of Urology |
| Volume | 68 |
| Issue number | 6 |
| Publication status | Published - 1991 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Urology
Cite this
15-Hydroxyprostaglandin dehydrogenase activity in the lower genitourinary tract. A preliminary report. / Chang, C. C.; Lin, S. N.; Chen, F. S.; Chang, W. C.
In: British Journal of Urology, Vol. 68, No. 6, 1991, p. 579-581.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 15-Hydroxyprostaglandin dehydrogenase activity in the lower genitourinary tract. A preliminary report
AU - Chang, C. C.
AU - Lin, S. N.
AU - Chen, F. S.
AU - Chang, W. C.
PY - 1991
Y1 - 1991
N2 - In the pathway of prostaglandin inactivation, 15-hydroxyprostaglandin dehydrogenase (15-OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15-hydroxyl group into a 15-keto moiety in most derivatives of prostaglandins. In this study, we analysed 15-OHPGDH activity in the lower genitourinary tract. The specimens were obtained with permission from patients who underwent surgery. These specimens were then sent for quantitative determination using a tritium release assay specific for 15-OHPGDH. The highest enzyme activity was found in the ureter with a mean ± SE (pmol/min/mg) of 94.99 ± 51.00; the lowest activity was in the vas deferens, with a value of 0.18 ± 0.21. This preliminary study indicated that the activity of 15-OHPGDH in the lower genitourinary tract was significant and that prostaglandin levels in the genitourinary tract may be regulated by this enzyme.
AB - In the pathway of prostaglandin inactivation, 15-hydroxyprostaglandin dehydrogenase (15-OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15-hydroxyl group into a 15-keto moiety in most derivatives of prostaglandins. In this study, we analysed 15-OHPGDH activity in the lower genitourinary tract. The specimens were obtained with permission from patients who underwent surgery. These specimens were then sent for quantitative determination using a tritium release assay specific for 15-OHPGDH. The highest enzyme activity was found in the ureter with a mean ± SE (pmol/min/mg) of 94.99 ± 51.00; the lowest activity was in the vas deferens, with a value of 0.18 ± 0.21. This preliminary study indicated that the activity of 15-OHPGDH in the lower genitourinary tract was significant and that prostaglandin levels in the genitourinary tract may be regulated by this enzyme.
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M3 - Article
C2 - 1773286
AN - SCOPUS:0025885502
VL - 68
SP - 579
EP - 581
JO - BJU International
JF - BJU International
SN - 1464-4096
IS - 6
ER -