15-Hydroxyprostaglandin dehydrogenase activity in the lower genitourinary tract. A preliminary report

C. C. Chang, S. N. Lin, F. S. Chen, W. C. Chang

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Abstract

In the pathway of prostaglandin inactivation, 15-hydroxyprostaglandin dehydrogenase (15-OHPGDH) has been proven to be the catalyst of the primary catabolic step in the oxidation of the 15-hydroxyl group into a 15-keto moiety in most derivatives of prostaglandins. In this study, we analysed 15-OHPGDH activity in the lower genitourinary tract. The specimens were obtained with permission from patients who underwent surgery. These specimens were then sent for quantitative determination using a tritium release assay specific for 15-OHPGDH. The highest enzyme activity was found in the ureter with a mean ± SE (pmol/min/mg) of 94.99 ± 51.00; the lowest activity was in the vas deferens, with a value of 0.18 ± 0.21. This preliminary study indicated that the activity of 15-OHPGDH in the lower genitourinary tract was significant and that prostaglandin levels in the genitourinary tract may be regulated by this enzyme.

Original languageEnglish
Pages (from-to)579-581
Number of pages3
JournalBritish Journal of Urology
Volume68
Issue number6
Publication statusPublished - 1991
Externally publishedYes

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15-hydroxyprostaglandin dehydrogenase
Prostaglandins
Vas Deferens
Tritium
Enzymes
Ureter
Hydroxyl Radical

ASJC Scopus subject areas

  • Urology

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15-Hydroxyprostaglandin dehydrogenase activity in the lower genitourinary tract. A preliminary report. / Chang, C. C.; Lin, S. N.; Chen, F. S.; Chang, W. C.

In: British Journal of Urology, Vol. 68, No. 6, 1991, p. 579-581.

Research output: Contribution to journalArticle

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