135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) to Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice

Guang Cheng Wu, Shyr Yi Lin, Hong Jen Liang, Wen Chi Hou

Research output: Contribution to journalArticle


The C57BL/6J mice were fed a 135-day normal diet or a high-fat diet (HFD) without, or concurrent with, a single yam dioscorin (80 mg/kg) or dipeptide NW (40 mg/kg) intervention every day. The final body weights (g) of mice were 26.1 ± 1.4, 34.97 ± 2.1, 31.75 ± 2.6, and 31.66 ± 3.1, respectively, for normal diet-fed, HFD-fed, dioscorin-intervened, and NW-intervened group. The mice in both intervened groups showed similar less weight gains and had significant differences (P < 0.05) compared to those in the HFD group under the same cumulative HFD intakes. The blood biochemical index of mice with dioscorin interventions showed significantly lower contents in total cholesterol and low-density lipoprotein, and NW interventions showed significantly lower total triglyceride contents compared to those of the HFD group (P < 0.05). Both intervened mice exhibited similar reductions in total visceral lipid contents and have significant differences compared to those of the HFD group (P < 0.05). The dioscorin intervention was better than NW interventions in lowering blood glucose levels by oral glucose tolerance tests and both showed significant differences (P < 0.05) compared to those in the HFD group. Yam dioscorin or dipeptide NW will potentially be used for preventive functional foods of less body weight gains and impaired glucose tolerance controls, which require further clinical trial investigations.

Original languageEnglish
Pages (from-to)645-652
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Issue number3
Publication statusPublished - Jan 24 2018



  • Asn-Trp (NW)
  • high-fat diet (HFD)
  • obesity
  • oral glucose tolerance tests
  • yam dioscorin
  • Blood Glucose/metabolism
  • Humans
  • Mice, Inbred C57BL
  • Male
  • Diet, High-Fat/adverse effects
  • Glucose Intolerance
  • Dipeptides/administration & dosage
  • Lipoproteins, LDL/blood
  • Dioscorea/chemistry
  • Animals
  • Plant Proteins/administration & dosage
  • Triglycerides/blood
  • Weight Gain/drug effects
  • Mice
  • Obesity/drug therapy

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this