12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents

Wei Feng, Mavurapu Satyanarayana, Yuan Chin Tsai, Angela A. Liu, Leroy F. Liu, Edmond J. LaVoie

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

2,3-Dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine and a few of its 12-substituted analogs are active as TOP1-targeting agents. Studies were performed to further evaluate the potential of this series of non-camptothecin TOP1-targeting agents. The influence of a hydroxymethyl, formyl, N,N-dimethylaminomethyl, 2-(N,N-dimethylamino)ethyl, 3-(N,N-dimethylamino)propyl), and 4-(N,N-dimethylamino)butyl substituent at the 12-position on TOP1-targeting activity and tumor cell growth was evaluated. In addition, the relative pharmacologic activities of the 12-carboxamide analog, as well as its N-methyl and N,N-dimethyl derivatives were assessed.

Original languageEnglish
Pages (from-to)2877-2885
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume17
Issue number7
DOIs
Publication statusPublished - Apr 1 2009
Externally publishedYes

Fingerprint

Phenanthridines
Type I DNA Topoisomerase
Antineoplastic Agents
Cell growth
Growth
Tumors
Neoplasms
Derivatives

Keywords

  • Benzo[i]phenanthridines
  • Cytotoxicity
  • Structure-activity
  • Topoisomerase I

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents. / Feng, Wei; Satyanarayana, Mavurapu; Tsai, Yuan Chin; Liu, Angela A.; Liu, Leroy F.; LaVoie, Edmond J.

In: Bioorganic and Medicinal Chemistry, Vol. 17, No. 7, 01.04.2009, p. 2877-2885.

Research output: Contribution to journalArticle

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AU - Tsai, Yuan Chin

AU - Liu, Angela A.

AU - Liu, Leroy F.

AU - LaVoie, Edmond J.

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