1-Benzyl-3-(5′-hydroxymethyl-2′-furyl)-indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis

Jin Cherng Lien, Fang Yu Lee, Li Jiau Huang, Shiow Lin Pan, Jih Hwa Guh, Che Ming Teng, Sheng Chu Kuo

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Antiapoptotic agents based on 1-benzyl-3-(5′-hydroxymethyl-2′-furyl)indazole (22, YC-1) derivatives were explored for effective treatment of sepsis and septic shock. We found that compound 22, 1-benzyl-3-(5′-methoxymethyl-2′-furyl)indazole (27), and 1-phenyl-3-(5′-hydroxymethyl-2′-furyl)-indazole (23) were the most effective inhibitors of sodium nitroprusside-induced vascular smooth muscle cell apoptosis. These three compounds are proposed as potential therapeutic agents for the treatment of sepsis.

Original languageEnglish
Pages (from-to)4947-4949
Number of pages3
JournalJournal of Medicinal Chemistry
Volume45
Issue number23
DOIs
Publication statusPublished - Nov 7 2002
Externally publishedYes

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Indazoles
Nitroprusside
Sepsis
Apoptosis
Derivatives
Septic Shock
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Cells
Therapeutics

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

1-Benzyl-3-(5′-hydroxymethyl-2′-furyl)-indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis. / Lien, Jin Cherng; Lee, Fang Yu; Huang, Li Jiau; Pan, Shiow Lin; Guh, Jih Hwa; Teng, Che Ming; Kuo, Sheng Chu.

In: Journal of Medicinal Chemistry, Vol. 45, No. 23, 07.11.2002, p. 4947-4949.

Research output: Contribution to journalArticle

Lien, Jin Cherng ; Lee, Fang Yu ; Huang, Li Jiau ; Pan, Shiow Lin ; Guh, Jih Hwa ; Teng, Che Ming ; Kuo, Sheng Chu. / 1-Benzyl-3-(5′-hydroxymethyl-2′-furyl)-indazole (YC-1) derivatives as novel inhibitors against sodium nitroprusside-induced apoptosis. In: Journal of Medicinal Chemistry. 2002 ; Vol. 45, No. 23. pp. 4947-4949.
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