The main purpose of this study was to explore substance abuse prevention education, and needs assessment for parents of high-risk students. The study used a cross-sectional design and a structured questionnaire to collect data from parents of high-risk students. In total, there were 122 subjects and the effective size was 97. Ninety-seven parents (50 fathers and 47 mothers) responded to the questionnaire. The results were as follows: (1) Parents of high-risk students reported they needed to learn more about parent education. (2) Parents obtained education, including ”reading books, newspapers, magazines and other written materials” and ”watching television or videotapes.” The most convenient time for the parents to participate in parent education was during weekends and holidays. The teaching materials that the parents liked most were videotapes and object demonstration. (3) The most frequent prevention strategy adopted by the parents was ”assisting their children to develop life skills,” with ”parent role” and ”identifying and dealing with problems” being the least frequently adopted prevention strategies. The findings can serve as reference for future parent education of substance abuse prevention.