The purposes of the study were to explore the knowledge of exercise-induced asthma (EIA), self-efficacy of EIA prevention and management, prevention and management of EIA behavior, and physical activities, as well as to build up an education program and test its effectiveness. Experiment design and purposive sampling were utilized. The study was conducted at the outpatient department of a medical center in southern Taiwan. Fifty-seven patients with asthma were randomly assigned to an experimental group (n=29) or a control group (n=28). Results were as follows: (1) The scores of knowledge of EIA (10.84±1.83), of self-efficacy of EIA prevention and management (87.23±13.32), and of physical activities (40.49±11.70)were at a moderately high level. Prevention and management of EIA behaviors (68.65±15.76)were at a moderate level. (2) The experimental group showed a significant improvement in EIA knowledge, self-efficacy of prevention and management EIA, prevention and management EIA behaviors (p＜0.01), and physical activities (p＜0.05). The findings of this study support the effectiveness of exercise-induced asthma education program, which can be used for clinical nurses to improve the quality of care in patients with asthma.